Results 71 to 80 of about 161,686 (253)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Cultivating Alliances: The Local Organic Food Co-ops Network

Canadian Journal of Nonprofit and Social Economy Research, 2015
Although social movements can lose their way in neoliberal times, building alliances can help them to leverage their strengths and overcome their weaknesses, thus avoiding co-optation and “mission drift.” One example of this strategy can be found within ...
Jennifer Sumner, Cassie Wever
doaj   +1 more source

The impacts of food chains: are alternative food networks sustainable?

Clean Technologies and Environmental Policy
Abstract The environmental impacts related to food production are of growing concern, with the phases of production and distribution that significantly contribute to greenhouse gas emissions. Among the call for sustainable food supply chains, Alternative Food Networks (AFNs) have emerged as alternatives to Large-Scale Retail (LSR ...
S. Falasco, G. Ferla, P. Caputo, B. Mura, B. Borrello, M. Marson, V. León Bravo, F. Caniato   +7 more
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Local food and alternative food networks: a communication perspective

Anthropology of food, 2007
Cet article propose de développer un cadre d’analyse fondé sur le pouvoir « transformationnel » des produits locaux, afin d’interpréter, et de supporter, la mise en place de stratégies de relocalisation alimentaire. Dans un premier temps nous présenterons un modèle sémiotique, servant de base à l’analyse de la qualité des produits alimentaires, et ...
openaire   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The resilience and viability of farmers markets in the United States as an alternative food network: case studies from Michigan during the COVID-19 pandemic. [PDF]

Agric Human Values, 2023
Wentworth C, Warsaw P, Isaacs K, Traore A, Hammon A, Lewis A.   +5 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

A relação entre comercialização de alimentos e princípios agroecológicos na rede de cooperativas de reforma agrária do Paraná/Brasil

Desenvolvimento e Meio Ambiente, 2016
The article analyzes the (in) compatibility between food market dynamics and agro ecological principles, studying a network of cooperatives created by agrarian reform farmers.
Oscar José Rover, Ademir de Jesus Riepe
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source