Results 61 to 70 of about 98,851 (303)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Linking Food Democracy and Sustainability on the Ground: Learnings from the Study of Three Alternative Food Networks in Brussels

Politics and Governance, 2019
The article explores and discusses, both conceptually and empirically, the exercise of food democracy in the context of three alternative food networks (AFNs) in Brussels, Belgium.
François Lohest, Tom Bauler, Solène Sureau, Joris Van Mol, Wouter M. J. Acten   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Navigating the Fault Lines in Civic Food Networks

Journal of Agriculture, Food Systems, and Community Development, 2016
Civic food networks have emerged as a civil society–driven response to the social, economic, and environmental shortcomings of the industrial food system.
Colin Ray Anderson, Wayne McDonald, Jo-Lene Gardiner, Stéphane M. McLachlan   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

What's Alternative about Alternative Food Networks? [PDF]

Environment and Planning A: Economy and Space, 2003
Whatmore, Sarah, Stassart, Pierre M, Rentjes, Henk   +2 more
openaire   +4 more sources

Alternative food networks and food provisioning as a gendered act

Agriculture and Human Values, 2014
Alternative food networks (AFNs) are exemplified by organic, fair trade and local foods, and promote forms of food provisioning that are ‘corrective’ to conventional agriculture and food (agrifood) systems. Despite enthusiasm for AFNs, scholars have increasingly interrogated whether inequalities are perpetuated by AFNs.
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Exploring the inter-connections between Alternative Agrifood and Seafood Networks for building food systems resilience

Canadian Food Studies
In the context of intensifying threats to food systems and a growing need for resilience, Alternative Agrifood Networks (AANs) and Alternative Seafood Networks (ASNs) have emerged as notable bright spots across North America. Collectively, AANs and ASNs
Kristen Lowitt, Charles Z. Levkoe, Sarah-Patricia Breen, Lindsay Harris, Hannah L. Harrison, Jon MacDonald, Phoebe Stephens, Joshua S. Stoll, Bruna Trevisan Negri, Connor Warne, Philip A. Loring   +10 more
doaj   +1 more source

Territorialisation dynamics for Italian farms adhering to Alternative Food Networks

Bulletin of Geography. Socio-Economic Series, 2018
The demographic processes of the last decades have led to variations in urban and peri-urban territorial configurations, questioning the patterns of traditional productive localisation.
Marino Davide, Mastronardi Luigi, Giannelli Agostino, Giaccio Vincenzo, Mazzocchi Giampiero   +4 more
doaj   +1 more source