Results 71 to 80 of about 98,851 (303)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Hungry for change: the Sydney Food Fairness Alliance [PDF]

open access: yes, 2012
The Sydney Food Fairness Alliance is one of a growing number of nascent food movements in Australia to have emerged out of concern for the country’s food future, as well as the deleterious effect the present food system is having on its ...
Frances Parker, Elizabeth Morgan
core   +1 more source

Alternative Food Networks, Social Capital, and Public Policy in Mexico City

open access: yes, 2022
Social initiatives that seek to promote socially fairer and environmentally more sustainable food production and distribution schemes have multiplied in the last two decades.
David Sébastien Monachon   +3 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Local food and alternative food networks: a communication perspective

open access: yesAnthropology of food, 2007
Cet article propose de développer un cadre d’analyse fondé sur le pouvoir « transformationnel » des produits locaux, afin d’interpréter, et de supporter, la mise en place de stratégies de relocalisation alimentaire. Dans un premier temps nous présenterons un modèle sémiotique, servant de base à l’analyse de la qualité des produits alimentaires, et ...
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Review of perspectives applied in the assessment of organic food networks

open access: yes, 2012
Value is a key concept for understanding how organic food networks function because values are the foundation of the organic production practice, thus value must be given a significant role in assessing and balancing the effects of organic food networks.
Noe, Egon   +2 more
core  

Alternative food networks in Kraków, Poland: Investigating the development of alternative food networks in the context of post-transformation processes in Kraków, Poland [PDF]

open access: yes
This master's thesis explores the emergence and impact of alternative food networks in the region of Kraków. More specifically, this thesis explores these networks within the context of post-transformation processes in Poland.
Abbt, Juliette
core   +1 more source

What is alternative about Alternative Agri-Food Networks? A research agenda towards an interdisciplinary assessment

open access: yesScienze del Territorio, 2014
The paper outlines a framework of the existing literature upon Alternative Food Networks moving from four different although interrelated standpoints: territorial, environmental, economic, and sociological.
Filippo Barbera   +5 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

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