Results 261 to 270 of about 248,399 (331)

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang   +14 more
wiley   +1 more source

Photoinduced Selective Construction of Densely Functionalized Spirocyclic Ethers With Carbyne Equivalents

open access: yesAngewandte Chemie, EarlyView.
A reactivity programmed cascade between carbyne equivalents and allylic benzoates was developed that sequentially orchestrates all three reactivity modes of carbyne equivalents, enabling the rapid installation of three σ‐bonds at a single carbon center and providing efficient, scalable access to structurally diverse spirocyclic ethers. ABSTRACT Carbyne
Jianke Su   +5 more
wiley   +2 more sources

In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis [PDF]

open access: yes, 2017
Akagi   +41 more
core   +2 more sources

The Effect of Silk on the Stabilization of Labile Enzyme Lipoxygenase

open access: yesAdvanced NanoBiomed Research, EarlyView.
Entrapping lipoxygenase within silk significantly extended its stability from under 24 h to 10 days. Variations in silk molecular weight and freeze‐drying conditions influenced silk properties and enzyme interactions. This stabilization is leveraged to develop a linoleic acid electrochemical biosensor, integrating lipoxygenase with horseradish ...
Jacopo Giaretta   +7 more
wiley   +1 more source

Aryl and Alkyl Radiotrifluoromethylation via Metallaphotoredox‐Mediated Radical Cross‐Coupling

open access: yesAngewandte Chemie, EarlyView.
The metallaphotoredox‐mediated radiotrifluoromethylation of arenes and alkanes is described. The operationally simple protocols make use of substrates bearing thianthrenium salts (TT) or N‐hydroxyphthalimide (NHPI) esters and CF218FI. The reaction proceeds through a Ru‐mediated radical formation followed by a Cu‐mediated radical cross‐coupling step and
Lukas Veth   +2 more
wiley   +2 more sources

Expression of Alternative Oxidase Influences Cell Migration

open access: yes, 2019
Solujen liikkumisella eli migraatiolla on tärkeä rooli yksilönkehityksessä, kudosvaurioiden korjaamisessa, immuunijärjestelmässä sekä yleisesti kudosten toiminnassa. Solumigraation ongelmat liittyvät moninaisiin kehityshäiriöihin ja sairauksiin. Drosophila melanogaster -banaanikärpäsellä puutteellinen solujen migraatio yksilönkehityksen aikana ...
openaire   +2 more sources

On the Molecular Diffusion Dynamics Between Subcutaneous Tissue and Microneedles for Wearable Continuous Glucose Monitoring

open access: yesAdvanced NanoBiomed Research, EarlyView.
In this study, we investigate the dynamics of glucose diffusion between subcutaneous tissue and hydrogel‐filled microneedles. Specifically, we examine how hydrogel thickness, microneedle size, and glucose concentration influence diffusion. This study provides an experimental reference to the wearable biosensor community researching microneedle‐based ...
Wensheng Lin   +9 more
wiley   +1 more source

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