Alternative expression of platelet glycoprotein Ib(beta) mRNA from an adjacent 5' gene with an imperfect polyadenylation signal sequence. [PDF]
, 1997 Barbara Zieger +2 more
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Diversity of U1 Small Nuclear RNAs and Diagnostic Methods for Their Mutations
Cancer Science, Volume 116, Issue 8, Page 2270-2280, August 2025.Complex interindividual U1 snRNA diversity was unveiled. Mutations in such complex loci were precisely detected with a pangenome graph reference, which enhances the possibility of the human pangenome reference in cancer genomics. ABSTRACT U1 small nuclear RNA (snRNA) mutations are recurrent non‐coding alterations found in various malignancies, yet ...
Takuma Nakashima +15 more
wiley +1 more source
The TP53 tumor suppressor gene: From molecular biology to clinical investigations
Journal of Internal Medicine, Volume 298, Issue 2, Page 78-96, August 2025.Abstract Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology. TP53 is the most frequently mutated gene in human malignancies, 50% of which carry alterations to it.
Panagiotis Baliakas, Thierry Soussi
wiley +1 more source
Global analysis of regulatory divergence in the evolution of mouse alternative polyadenylation
Molecular Systems Biology, 2016 Alternative polyadenylation (APA), which is regulated by both cis‐elements and trans‐factors, plays an important role in post‐transcriptional regulation of eukaryotic gene expression.
Mei‐Sheng Xiao +5 more
doaj +1 more source
The genetics and genomics of Trypanosoma cruzi [PDF]
, 2007 Trypanosoma cruzi is a kinetoplastid parasite that causes Chagas disease. Trypanosomes are unusual organisms in many aspects of its genetics and molecular and cellular biology and considered a paradigm of the exception of the rule in the eukaryotic ...
Vazquez, Martin Pablo
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Regulation of gene expression by alternative polyadenylation and mRNA instability in hyperglycaemic mesangial cells [PDF]
, 1998 Nadia Abdel Wahab +2 more
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NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in Arabidopsis. [PDF]
, 2019 The 5' end of a eukaryotic mRNA transcript generally has a 7-methylguanosine (m7G) cap that protects mRNA from degradation and mediates almost all other aspects of gene expression.
Cai, Zongwei +7 more
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Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. [PDF]
, 2020 Gpr27 is a highly conserved, orphan G protein coupled receptor (GPCR) previously implicated in pancreatic beta cell insulin transcription and glucose-stimulated insulin secretion in vitro. Here, we characterize a whole-body mouse knockout of Gpr27. Gpr27
Chopra, Deeksha G +4 more
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Ovarian- and Somatic-specific Transcripts of the Mosquito Clathrin Heavy Chain Gene Generated by Alternative 5′-Exon Splicing and Polyadenylation [PDF]
, 1997 Vladimir Kokoza, Alexander S. Raikhel
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Exploring the untapped potential of single‐cell and spatial omics in plant biology
New Phytologist, Volume 247, Issue 3, Page 1098-1116, August 2025.Summary Advances in single‐cell and spatial omics technologies have revolutionised biology by revealing the diverse molecular states of individual cells and their spatial organization within tissues. The field of plant biology has widely adopted single‐cell transcriptome and chromatin accessibility profiling and spatial transcriptomics, which extend ...
Tatsuya Nobori
wiley +1 more source