Results 51 to 60 of about 344,150 (327)
Computational prediction of splicing regulatory elements shared by Tetrapoda organisms [PDF]
, 2009 Background: auxiliary splicing sequences play an important role in ensuring accurate and efficient splicing by promoting or repressing recognition of authentic splice sites.
Churbanov, Alexander +2 more
core +3 more sources
Alternative splicing regulation and its therapeutic potential in bladder cancer
Frontiers in OncologyBladder cancer is one of the leading causes of mortality globally. The development of bladder cancer is closely associated with alternative splicing, which regulates human gene expression and enhances the diversity of functional proteins.
Lina Li, Ting Jin, Liang Hu, Jin Ding
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FreePSI: an alignment-free approach to estimating exon-inclusion ratios without a reference transcriptome. [PDF]
, 2017 Alternative splicing plays an important role in many cellular processes of eukaryotic organisms. The exon-inclusion ratio, also known as percent spliced in, is often regarded as one of the most effective measures of alternative splicing events.
Jiang, Tao +4 more
core +1 more source
iScience, 2022 Summary: Alternative splicing is crucial for a wide range of biological processes. However, limited by the availability of reference genomes, genome-wide patterns of alternative splicing remain unknown in most nonmodel organisms.
Lei Cao +4 more
doaj +1 more source
Alternative Splicing in CKD [PDF]
Journal of the American Society of Nephrology, 2016 Alternative splicing (AS) has emerged in the postgenomic era as one of the main drivers of proteome diversity, with ≥94% of multiexon genes alternatively spliced in humans. AS is therefore one of the main control mechanisms for cell phenotype, and is a process deregulated in disease.
Stevens, Megan, Oltean, Sebastian
openaire +3 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Nutrition & Metabolism, 2018 Background In a previous study, we showed that consumption of diets enriched in saturated fatty acids causes changes in alternative splicing of pre-mRNAs encoding a number of proteins in rat skeletal muscle, including the one encoding skeletal muscle ...
Adam J. Black +2 more
doaj +1 more source
Alternative splicing: global insights [PDF]
The FEBS Journal, 2010 Following the original reports of pre‐mRNA splicing in 1977, it was quickly realized that splicing together of different combinations of splice sites – alternative splicing– allows individual genes to generate more than one mRNA isoform. The full extent of alternative splicing only began to be revealed once large‐scale genome and transcriptome ...
Hallegger, M, Llorian, M, Smith, C
openaire +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source