Results 51 to 60 of about 249,606 (193)
CD44 alternative splicing is a sensor of intragenic DNA methylation in tumors [PDF]
arXiv, 2019 DNA methylation (meDNA) is a suspected modulator of alternative splicing, while splicing in turn is involved in tumour formations nearly as frequently as DNA mutations. Yet, the impact of meDNA on tumorigenesis via its effect on splicing has not been thoroughly explored. Here, we find that HCT116 colon carcinoma cells inactivated for the DNA methylases
arxiv
The Alternative Choice of Constitutive Exons throughout Evolution [PDF]
PLoS Genet 2007 3(11): e203, 2008 Alternative cassette exons are known to originate from two processes exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced exons become alternative cassette exons during evolution. We compiled a dataset of orthologous exons from human and mouse that are constitutively spliced in
arxiv
The Functional Impact of Alternative Splicing in Cancer [PDF]
Cell Reports, 2016 SummaryAlternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for tumor progression and therapy. However, their functional impact and relevance to tumorigenesis remains mostly unknown.
Eduard Porta-Pardo +4 more
openaire +10 more sources
Analysis of differential splicing suggests different modes of short-term splicing regulation [PDF]
arXiv, 2016 Motivation: Alternative splicing is an important mechanism in which the regions of pre-mRNAs are differentially joined in order to form different transcript isoforms. Alternative splicing is involved in the regulation of normal physiological functions but also linked to the development of diseases such as cancer.
arxiv
Regrowing axons with alternative splicing [PDF]
eLife, 2016 The regeneration of axons relies on a previously unknown mechanism that involves the regulation of alternative splicing by CELF proteins.
Nicholas J Kramer, Aaron D Gitler
openaire +3 more sources
Detection and Visualization of Differential Splicing in RNA-Seq Data with JunctionSeq [PDF]
, 2015 Although RNA-Seq data provide unprecedented isoform-level expression information, detection of alternative isoform regulation (AIR) remains difficult, particularly when working with an incomplete transcript annotation. We introduce JunctionSeq, a new method that builds on the statistical techniques used by the well-established DEXSeq package to detect ...
arxiv +1 more source
High-resolution transcriptome analysis with long-read RNA sequencing [PDF]
, 2014 RNA sequencing (RNA-seq) enables characterization and quantification of individual transcriptomes as well as detection of patterns of allelic expression and alternative splicing. Current RNA-seq protocols depend on high-throughput short-read sequencing of cDNA.
arxiv +1 more source
Intronic Alus Influence Alternative Splicing [PDF]
PLoS Genet 2008 4(9): e1000204, 2008 Examination of the human transcriptome reveals higher levels of RNA editing than in any other organism tested to date. This is indicative of extensive double-stranded RNA (dsRNA) formation within the human transcriptome. Most of the editing sites are located in the primate-specific retrotransposed element called Alu.
arxiv
Transcriptional elongation and alternative splicing
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013 Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk between these two nuclear processes.
Dujardin, Gwendal +11 more
openaire +4 more sources
Combinatorial regulation of alternative splicing
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019 The generation of protein coding mRNAs from pre-mRNA is a fundamental biological process that is required for gene expression. Alternative pre-mRNA splicing is responsible for much of the transcriptomic and proteomic diversity observed in higher order eukaryotes.
Shenasa, Hossein, Hertel, Klemens J
openaire +4 more sources