Results 51 to 60 of about 411,790 (378)
Alternative Splicing in Neurogenesis and Brain Development
Frontiers in Molecular Biosciences, 2018 Alternative splicing of precursor mRNA is an important mechanism that increases transcriptomic and proteomic diversity and also post-transcriptionally regulates mRNA levels.
Chun-Hao Su +4 more
doaj +1 more source
RNA Alternative Splicing Prediction with Discrete Compositional Energy Network [PDF]
arXiv, 2021 A single gene can encode for different protein versions through a process called alternative splicing. Since proteins play major roles in cellular functions, aberrant splicing profiles can result in a variety of diseases, including cancers. Alternative splicing is determined by the gene's primary sequence and other regulatory factors such as RNA ...
arxiv
Latent rank change detection for analysis of splice-junction microarrays with nonlinear effects [PDF]
Annals of Applied Statistics 2011, Vol. 5, No. 1, 364-380, 2011 Alternative splicing of gene transcripts greatly expands the functional capacity of the genome, and certain splice isoforms may indicate specific disease states such as cancer. Splice junction microarrays interrogate thousands of splice junctions, but data analysis is difficult and error prone because of the increased complexity compared to ...
arxiv +1 more source
Alternative Splicing in Myeloid Malignancies [PDF]
Biomedicines, 2021 Alternative RNA splicing (AS) is an essential physiologic function that diversifies the human proteome. AS also has a crucial role during cellular development. In fact, perturbations in RNA-splicing have been implicated in the development of several cancers, including myeloid malignancies.
Carmelo Gurnari +2 more
openaire +4 more sources
The importance of being divisible by three in alternative splicing [PDF]
, 2005 Alternative splicing events that are conserved in orthologous genes in different species are commonly viewed as reliable evidence of authentic, functionally significant alternative splicing events.
Ast, Gil, Magen, Alon
core +4 more sources
The Perils of Navigating Activity-Dependent Alternative Splicing of Neurexins
Frontiers in Molecular Neuroscience, 2021 Neurexins are presynaptic cell-adhesion molecules essential for synaptic function that are expressed in thousands of alternatively spliced isoforms. Recent studies suggested that alternative splicing at splice site 4 (SS4) of Nrxn1 is tightly regulated ...
Kif Liakath-Ali +3 more
doaj +1 more source
Evolution of Alternative Splicing in Eudicots [PDF]
Frontiers in Plant Science, 2019 Alternative pre-mRNA splicing (AS) is prevalent in plants and is involved in many interactions between plants and environmental stresses. However, the patterns and underlying mechanisms of AS evolution in plants remain unclear. By analyzing the transcriptomes of four eudicot species, we revealed that the divergence of AS is largely due to the gains and
Ling, Z. (Zhihao) +3 more
openaire +7 more sources
Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors. [PDF]
, 2015 Genome-wide association studies have identified over 70 single-nucleotide polymorphisms (SNPs) associated with breast cancer. A subset of these SNPs are associated with quantitative expression of nearby genes, but the functional effects of the majority ...
Brenner, Steven E +8 more
core +2 more sources
regulAS: A Bioinformatics Tool for the Integrative Analysis of Alternative Splicing Regulome using RNA-Seq data [PDF]
, 2023 The regulAS software package is a bioinformatics tool designed to support computational biology researchers in investigating regulatory mechanisms of splicing alterations through integrative analysis of large-scale RNA-Seq data from cancer and healthy human donors, characterized by TCGA and GTEx projects.
arxiv +1 more source
The role of alternative pre-mRNA splicing in cancer progression
Cancer Cell International, 2023 Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of specific splicing isoforms in cellular processes,
Sunkyung Choi +3 more
doaj +1 more source