Results 51 to 60 of about 326,335 (355)
The role of alternative pre-mRNA splicing in cancer progression
Cancer Cell International, 2023 Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of specific splicing isoforms in cellular processes,
Sunkyung Choi +3 more
doaj +1 more source
A minor alternative transcript of the fumarylacetoacetate hydrolase gene produces a protein despite being likely subjected to nonsense-mediated mRNA decay [PDF]
, 2005 BACKGROUND: Coupling of alternative splicing with nonsense-mediated mRNA decay (NMD) may regulate gene expression. We report here the identification of a nonsense alternative transcript of the fumarylacetoacetate hydrolase (fah) gene, which produces a ...
Bergeron, Anne +4 more
core +3 more sources
BMC Evolutionary Biology, 2007 Background Alternative splicing has been reported in various eukaryotic groups including plants, apicomplexans, diatoms, amoebae, animals and fungi. However, whether widespread alternative splicing has evolved independently in the different eukaryotic ...
Penny David +3 more
doaj +1 more source
Complex Alternative Splicing [PDF]
, 2007 Alternative splicing is a powerful means of controlling gene expression and increasing protein diversity. Most genes express a limited number of mRNA isoforms, but there are several examples of genes that use alternative splicing to generate hundreds, thousands and even tens of thousands of isoforms.
Jung Woo Park, Brenton R. Graveley
openaire +3 more sources
The role of alternative splicing in cancer [PDF]
Transcription, 2017 The functional capacity of cells is defined by the transcriptome. Many recent studies have identified variations in the transcriptome of tumors due to alternative splicing changes, as well as mutations in splicing factors and regulatory signals in most tumor types.
Babita Singh, Eduardo Eyras
openaire +4 more sources
Nutrition & Metabolism, 2018 Background In a previous study, we showed that consumption of diets enriched in saturated fatty acids causes changes in alternative splicing of pre-mRNAs encoding a number of proteins in rat skeletal muscle, including the one encoding skeletal muscle ...
Adam J. Black +2 more
doaj +1 more source
A Novel Prognostic Index Based on Alternative Splicing in Papillary Renal Cell Carcinoma
Frontiers in Genetics, 2020 BackgroundPapillary renal cell carcinoma (pRCC) is a heterogeneous multifocal or isolated tumor with an invasive phenotype. Previous studies presented that alternative splicing, as a crucial posttranscriptional regulator in gene expression, is associated
Zhipeng Wu +6 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Alternative Splicing for Diseases, Cancers, Drugs, and Databases
The Scientific World Journal, 2013 Alternative splicing is a major diversification mechanism in the human transcriptome and proteome. Several diseases, including cancers, have been associated with dysregulation of alternative splicing.
Jen-Yang Tang +6 more
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Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals. [PDF]
, 2019 ObjectiveThe NCoR-1 and NCoR-2 corepressors are products of an early gene duplication near the beginning of vertebrate evolution and play both overlapping and divergent roles in development and physiology.
Goodson, Michael L, Privalsky, Martin L
core