Results 61 to 70 of about 3,593,907 (372)

A Novel Prognostic Index Based on Alternative Splicing in Papillary Renal Cell Carcinoma

Frontiers in Genetics, 2020
BackgroundPapillary renal cell carcinoma (pRCC) is a heterogeneous multifocal or isolated tumor with an invasive phenotype. Previous studies presented that alternative splicing, as a crucial posttranscriptional regulator in gene expression, is associated
Zhipeng Wu, Jinhui Liu, Rui Sun, Dongming Chen, Kai Wang, Changchun Cao, Xianlin Xu   +6 more
doaj   +1 more source

Alternative promoters influence alternative splicing at the genomic level. [PDF]

PLoS ONE, 2008
BACKGROUND: More and more experiments have shown that transcription and mRNA processing are not two independent events but are tightly coupled to each other. Both promoter and transcription rate were found to influence alternative splicing.
Dedong Xin, Landian Hu, Xiangyin Kong
doaj   +1 more source

MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells [PDF]

, 2016
A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized ...
Cappella, Marisa, Cardinali, B., Cittaro, D., Falcone, G., Garcia Manteiga, J. M., Lazarevic, D., Martelli, F, Provenzano, C.   +7 more
core   +2 more sources

Diverse alternative back-splicing and alternative splicing landscape of circular RNAs

Genome Research, 2016
Circular RNAs (circRNAs) derived from back-spliced exons have been widely identified as being co-expressed with their linear counterparts. A single gene locus can produce multiple circRNAs through alternative back-splice site selection and/or alternative
Xiao-Ou Zhang, Rui Dong, Yang Zhang, Jia-Lin Zhang, Zheng Luo, Jun Zhang, Ling-Ling Chen, Li Yang   +7 more
semanticscholar   +1 more source

Positional proteomics reveals differences in N-terminal proteoform stability [PDF]

, 2016
To understand the impact of alternative translation initiation on a proteome, we performed a proteome-wide study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes.
Brown JL, Daria Gawron, Elvis Ndah, Kris Gevaert, Petra Van Damme   +4 more
core   +2 more sources

Alternative Splicing: Emerging Roles in Anti-Aging Strategies

Biomolecules
Alternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence.
Lingyue Gao, Rong Jia
doaj   +1 more source

Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing

BMC Evolutionary Biology, 2007
Background Alternative splicing has been reported in various eukaryotic groups including plants, apicomplexans, diatoms, amoebae, animals and fungi. However, whether widespread alternative splicing has evolved independently in the different eukaryotic ...
Penny David, Rukov Jakob, Irimia Manuel, Roy Scott   +3 more
doaj   +1 more source

The role of alternative pre-mRNA splicing in cancer progression

Cancer Cell International, 2023
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of specific splicing isoforms in cellular processes,
Sunkyung Choi, Namjoon Cho, Eun-Mi Kim, Kee K. Kim   +3 more
doaj   +1 more source

The CUGBP2 splicing factor regulates an ensemble of branchpoints from perimeter binding sites with implications for autoregulation [PDF]

, 2009
Alternative pre-mRNA splicing adjusts the transcriptional output of the genome by generating related mRNAs from a single primary transcript, thereby expanding protein diversity.
Dembowski, JA, Grabowski, PJ
core   +5 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source