Results 61 to 70 of about 336,398 (336)

Computational prediction of splicing regulatory elements shared by Tetrapoda organisms [PDF]

, 2009
Background: auxiliary splicing sequences play an important role in ensuring accurate and efficient splicing by promoting or repressing recognition of authentic splice sites.
Churbanov, Alexander, Hicks, Chindo, Vořechovský, Igor   +2 more
core   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Interrogation of alternative splicing events in duplicated genes during evolution

BMC Genomics, 2011
Background Gene duplication provides resources for developing novel genes and new functions while retaining the original functions. In addition, alternative splicing could increase the complexity of expression at the transcriptome and proteome level ...
Chen Ting-Wen, Wu Timothy H, Ng Wailap V, Lin Wen-Chang   +3 more
doaj   +1 more source

FreePSI: an alignment-free approach to estimating exon-inclusion ratios without a reference transcriptome. [PDF]

, 2017
Alternative splicing plays an important role in many cellular processes of eukaryotic organisms. The exon-inclusion ratio, also known as percent spliced in, is often regarded as one of the most effective measures of alternative splicing events.
Jiang, Tao, Ma, Shining, Wang, Dongfang, Zeng, Jianyang, Zhou, Jianyu   +4 more
core   +1 more source

Alternative splicing and muscular dystrophy [PDF]

RNA Biology, 2010
Alternative splicing of pre-mRNAs is a major contributor to proteomic diversity and to the control of gene expression in higher eukaryotic cells. For this reasons, alternative splicing is tightly regulated in different tissues and developmental stages and its disruption can lead to a wide range of human disorders.
Pistoni M, Ghigna C, Gabellini D
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Alternative splicing regulation and its therapeutic potential in bladder cancer

Frontiers in Oncology
Bladder cancer is one of the leading causes of mortality globally. The development of bladder cancer is closely associated with alternative splicing, which regulates human gene expression and enhances the diversity of functional proteins.
Lina Li, Ting Jin, Liang Hu, Jin Ding
doaj   +1 more source

DeepASmRNA: Reference-free prediction of alternative splicing events with a scalable and interpretable deep learning model

iScience, 2022
Summary: Alternative splicing is crucial for a wide range of biological processes. However, limited by the availability of reference genomes, genome-wide patterns of alternative splicing remain unknown in most nonmodel organisms.
Lei Cao, Quanbao Zhang, Hongtao Song, Kui Lin, Erli Pang   +4 more
doaj   +1 more source

An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor [PDF]

, 2002
The human IGF-I gene has six exons, four of which are alternatively spliced. Variations in splicing involving exon 5 may occur, depending on the tissue type and hormonal environment.
Chew, S. L., Coakley, J., Hinds, C. J., Krainer, A. R., Ross, R. J. M., Smith, P. J., Spurrell, E. L.   +6 more
core   +1 more source

Alternative splicing and protein function [PDF]

BMC Bioinformatics, 2005
Abstract Background Alternative splicing is a major mechanism of generating protein diversity in higher eukaryotes. Although at least half, and probably more, of mammalian genes are alternatively spliced, it was not clear, whether the frequency of alternative splicing is the same in different functional categories.
Neverov, A.D., Artamonova, I.I., Nurtdinov, R.N., Frishman, D., Gelfand, M.S., Mironov, A.A.   +5 more
openaire   +5 more sources