Understanding the temperature conditions for controlled splicing between silica and fluoride fibers [PDF]
This study explores the efficacy of thermal splicing conditions between silica and zirconium-fluoride fibers, focusing on achieving mechanical strength between the two fibers. A comprehensive characterization of the thermal profile in the hot zone of the filament splicer was conducted using a fiber Bragg grating, providing valuable insights into its ...
arxiv +1 more source
HIV-1 virus cycle replication: a review of RNA polymerase II transcription, alternative splicing and protein synthesis [PDF]
arXiv, 2019 HIV virus replication is a time-related process that includes several stages. Focusing on the core steps, RNA polymerase II transcripts in an early stage pre-mRNA containing regulator proteins (i.e nef,tat,rev,vif,vpr,vpu), which are completely spliced by the spliceosome complex (0.9kb and 1.8kb) and exported to the ribosome for protein synthesis ...
arxiv
A polynomial delay algorithm for the enumeration of bubbles with length constraints in directed graphs and its application to the detection of alternative splicing in RNA-seq data [PDF]
arXiv, 2013 We present a new algorithm for enumerating bubbles with length constraints in directed graphs. This problem arises in transcriptomics, where the question is to identify all alternative splicing events present in a sample of mRNAs sequenced by RNA-seq.
arxiv
CTCF Degradation Causes Increased Usage of Upstream Exons in Mouse Embryonic Stem Cells [PDF]
arXiv, 2018 Transcriptional repressor CTCF is an important regulator of chromatin 3D structure, facilitating the formation of topologically associating domains (TADs). However, its direct effects on gene regulation is less well understood. Here, we utilize previously published ChIP-seq and RNA-seq data to investigate the effects of CTCF on alternative splicing of ...
arxiv
Reconstructing Isoform Graphs from RNA-Seq data [PDF]
arXiv, 2011 Next-generation sequencing (NGS) technologies allow new methodologies for alternative splicing (AS) analysis. Current computational methods for AS from NGS data are mainly focused on predicting splice site junctions or de novo assembly of full-length transcripts.
arxiv
Selecting Differential Splicing Methods: Practical Considerations [PDF]
arXivAlternative splicing is crucial in gene regulation, with significant implications in clinical settings and biotechnology. This review article compiles bioinformatics RNA-seq tools for investigating differential splicing; offering a detailed examination of their statistical methods, case applications, and benefits. A total of 22 tools are categorised by
arxiv
Immunologically distinct p53 molecules generated by alternative splicing.
, 1986 Nobuyuki Arai +6 more
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Role of the branch site/3'-splice site region in adenovirus-2 E1A pre-mRNA alternative splicing: evidence for 5'- and 3'-splice site co-operation [PDF]
, 1989 Per Johan Ulfendahl +2 more
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