Results 71 to 80 of about 411,790 (378)
Methods to study splicing from high-throughput RNA Sequencing data [PDF]
Methods Mol Biol. 2014;1126:357-97, 2013 The development of novel high-throughput sequencing (HTS) methods for RNA (RNA-Seq) has provided a very powerful mean to study splicing under multiple conditions at unprecedented depth. However, the complexity of the information to be analyzed has turned this into a challenging task.
arxiv +1 more source
Alternative splicing and protein function [PDF]
BMC Bioinformatics, 2005 Abstract Background Alternative splicing is a major mechanism of generating protein diversity in higher eukaryotes. Although at least half, and probably more, of mammalian genes are alternatively spliced, it was not clear, whether the frequency of alternative splicing is the same in different functional categories.
Neverov, A.D. +5 more
openaire +5 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals. [PDF]
, 2019 ObjectiveThe NCoR-1 and NCoR-2 corepressors are products of an early gene duplication near the beginning of vertebrate evolution and play both overlapping and divergent roles in development and physiology.
Goodson, Michael L, Privalsky, Martin L
core
evolution, structure and function of metazoan splicing factor PRPF39 [PDF]
, 2019 In the yeast U1 snRNP the Prp39/Prp42 heterodimer is essential for early steps of spliceosome assembly. In metazoans no Prp42 ortholog exists, raising the question how the heterodimer is functionally substituted.
Bortoli, Francesca De +7 more
core +1 more source
Interrogation of alternative splicing events in duplicated genes during evolution
BMC Genomics, 2011 Background Gene duplication provides resources for developing novel genes and new functions while retaining the original functions. In addition, alternative splicing could increase the complexity of expression at the transcriptome and proteome level ...
Chen Ting-Wen +3 more
doaj +1 more source
Alternative Splicing for Diseases, Cancers, Drugs, and Databases
The Scientific World Journal, 2013 Alternative splicing is a major diversification mechanism in the human transcriptome and proteome. Several diseases, including cancers, have been associated with dysregulation of alternative splicing.
Jen-Yang Tang +6 more
doaj +1 more source
Nutrition & Metabolism, 2018 Background In a previous study, we showed that consumption of diets enriched in saturated fatty acids causes changes in alternative splicing of pre-mRNAs encoding a number of proteins in rat skeletal muscle, including the one encoding skeletal muscle ...
Adam J. Black +2 more
doaj +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
SplicingTypesAnno: Annotating and quantifying alternative splicing events for RNA-Seq data [PDF]
, 2015 © 2015 Elsevier Ireland Ltd. Alternative splicing plays a key role in the regulation of the central dogma. Four major types of alternative splicing have been classified as intron retention, exon skipping, alternative 5 splice sites or alternative donor ...
Guo, J +5 more
core +1 more source