Results 151 to 160 of about 52,032 (257)

The promise of cardiomyocyte computational models for drug safety. [PDF]

Mil Med Res
Wang L, Rodriguez B.
europepmc   +1 more source

Race is on to find alternative to animal tests [PDF]

Nature, 2002
openaire   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Artificial intelligence-, organoid-, and organ-on-chip-powered models to improve pre-clinical animal testing of vaccines and immunotherapeutics: potential, progress, and challenges. [PDF]

Front Artif Intell
Elfatimi E, Lekbach Y, Prakash S, Karan S, Dorotta JC, Garcia A, Suoth BS, Maurya C, Omorogieva EY, Ng SXL, Liao EJ, Chow RA, BenMohamed L.   +12 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Reusable multicriteria decision model to evaluate the integrated sustainability impacts of different alternatives of dietary substitutions. [PDF]

PLoS One
Pires SM, de Melo JF, Redondo HG, Assunção R, Boué G, Biasini B, Cozzi E, Jolliet O, Menozzi D, Vieira ACL.   +9 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Neuroscience meets food choice: Implicit and explicit consumer responses to plant-based vs animal-based foods. [PDF]

Curr Res Food Sci
Inguscio BMS, Carcaterra G, Cherubino P, Rossi D, Madini G, Fraccascia L, Babiloni F, Cartocci G.   +7 more
europepmc   +1 more source

Recent Developments in Alternatives to Animal Testing [PDF]

, 2019
openaire   +1 more source

Ten Years and Still no Alternatives to Animal Testing [PDF]

Journal of Toxicology: Cutaneous and Ocular Toxicology, 1993
openaire   +1 more source