Results 61 to 70 of about 261,784 (335)
Improvement of a Three-Layered in vitro Skin Model for Topical Application of Irritating Substances
Frontiers in Bioengineering and Biotechnology, 2020 In the field of skin tissue engineering, the development of physiologically relevant in vitro skin models comprising all skin layers, namely epidermis, dermis, and subcutis, is a great challenge.
Freia F. Schmidt +2 more
doaj +1 more source
Geographic variation in walking activity in the red flour beetle Tribolium castaneum
Population Ecology, EarlyView.This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley +1 more source
Metabolomics in Preclinical Drug Safety Assessment: Current Status and Future Trends
MetabolitesMetabolomics is emerging as a powerful systems biology approach for improving preclinical drug safety assessment. This review discusses current applications and future trends of metabolomics in toxicology and drug development.
Fenna Sillé, Thomas Hartung
doaj +1 more source
Animal-Friendly Affinity Reagents: Replacing the Needless in the Haystack [PDF]
, 2016 The multibillion-dollar global antibody industry produces an indispensable resource but that is generated using millions of animals. Despite the irrefutable maturation and availability of animal-friendly affinity reagents (AFAs) employing na€ive B ...
Borrebaeck, C. A.K. +4 more
core +2 more sources
occumb: An R package for site occupancy modeling of eDNA metabarcoding data
Population Ecology, EarlyView.This study introduces a new R package, occumb, for the convenient application of site occupancy modeling using environmental DNA (eDNA) metabarcoding data. We outline a data analysis workflow, including data setup, model fitting, model assessment, and comparison of potential study settings based on model predictions, all of which can be performed using
Keiichi Fukaya, Yuta Hasebe
wiley +1 more source
Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem
iScience, 2020 Summary: Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient ...
David Pamies +2 more
doaj
Give meaning to alternative methods to animal testing
ALTEX, 2019 n ...
Arti Ahluwalia, Anna Maria Bassi
openaire +4 more sources
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
The (misleading) role of animal models in drug development
Frontiers in Drug DiscoveryAnimals like mice and rats have long been used in medical research to help understand disease and test potential new treatments before human trials. However, while animal studies have contributed to important advances, too much reliance on animal models ...
Thomas Hartung, Thomas Hartung
doaj +1 more source