Results 1 to 10 of about 843,251 (286)

Evaluation of physico-chemical and heavy metals status in irrigation, stagnant, and Indus River water at the trans-Himalayan region

Discover Water, 2023
The water quality of various resources is changing everywhere, including the high-altitude region, which may have adverse health effects on animals and the human population.
Guru Charan, Vijay K. Bharti, Arup Giri, Prabhat Kumar   +3 more
doaj   +1 more source

Altitude illness

BMJ, 2003
Summary points: Altitude related illness is rare at altitudes below 2500 metres but is common in travellers to 3500 metres or more. The occurrence is increased by a rapid gain in altitude and reduced by a slow ascent, allowing time for acclimatisation. For most travellers, altitude related illness is an unpleasant but self limiting and benign syndrome,
Barry, P, Pollard, A
openaire   +4 more sources

Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma

Frontiers in Oncology, 2019
Hypoxia is a predominant feature in glioblastoma (GBM) and contributes greatly to its drug resistance. However, the molecular mechanisms which are responsible for the development of the resistant phenotype of GBM under hypoxic conditions remain unclear ...
Yixing Gao, Bao Liu, Bao Liu, Lan Feng, Lan Feng, Binda Sun, Binda Sun, Shu He, Shu He, Yidong Yang, Yidong Yang, Gang Wu, Gang Wu, Guoji E, Guoji E, Chang Liu, Chang Liu, Yuqi Gao, Yuqi Gao, Erlong Zhang, Erlong Zhang, Bo Zhu   +21 more
doaj   +1 more source

Memory impairment induced by exposure to simulated hypobaric hypoxia and phosphoproteomic analysis of hippocampus in mice

Di-san junyi daxue xuebao, 2022
Objective To observe the changes of protein phosphorylation levels in the hippocampus of mice with memory impairment caused by hypobaric hypoxia exposure, and to explore the key phosphorylated proteins and associated pathways involved in memory deficits.
DONG Huaping, ZHONG Zhifeng, LI Peng, HUANG Pei, TIAN Huaijun, XIE Jiaxin, ZHOU Simin   +6 more
doaj   +1 more source

Hematological Risk Factors for High-Altitude Headache in Chinese Men Following Acute Exposure at 3,700 m

Frontiers in Physiology, 2017
Background: High-altitude headache (HAH) is a notably common disorder affecting the daily life of travelers ascending to high altitude. Hematological parameters are important clinical examinations for various diseases.
He Huang, He Huang, He Huang, Bao Liu, Bao Liu, Bao Liu, Bao Liu, Gang Wu, Gang Wu, Gang Wu, Gang Xu, Gang Xu, Gang Xu, Bing-Da Sun, Bing-Da Sun, Bing-Da Sun, Yu-Qi Gao, Yu-Qi Gao, Yu-Qi Gao   +18 more
doaj   +1 more source

Adropin Is a Key Mediator of Hypoxia Induced Anti-Dipsogenic Effects via TRPV4-CamKK-AMPK Signaling in the Circumventricular Organs of Rats

Frontiers in Molecular Neuroscience, 2017
Water intake reduction (anti-dipsogenic effects) under hypoxia has been well established, but the underlying reason remains unknown. Our previous report indicated that activated TRPV4 neurons in SFO are associated with anti-dipsogenic effects under ...
Qing-Yuan Huang, Qing-Yuan Huang, Qing-Yuan Huang, Fan Yang, Fan Yang, Fan Yang, Li Zhou, Xu Qian, Dong Wang, Dong Wang, Dong Wang, Wen-Juan He, Wen-Juan He, Wen-Juan He, Zhong-wei Tang, Zhong-wei Tang, Zhong-wei Tang, Jun Yin, Jun Yin, Jun Yin   +19 more
doaj   +1 more source

Integrated pan-cancer analysis and experimental verification of the roles of tropomyosin 4 in gastric cancer

Frontiers in Immunology, 2023
ObjectiveTo investigate the function of tropomyosin 4 (TPM4) using pan-cancer data, especially in gastric cancer (GC), using comprehensive bioinformatics analysis and molecular experiments.MethodsWe used UCSC Xena, The Cancer Genome Atlas (TCGA ...
Qijing Guo, Qijing Guo, Linglin Zhao, Nan Yan, Yan Li, Cuiping Guo, Shengyan Dang, Xianliang Shen, Jianfang Han, Yushuang Luo, Yushuang Luo   +10 more
doaj   +1 more source

IL-6/STAT3 Induced Neuron Apoptosis in Hypoxia by Downregulating ATF6 Expression

Frontiers in Physiology, 2021
Background: Neuron apoptosis, regulated by endoplasmic reticulum (ER) stress in the hippocampus, is an essential factor influencing the cognitive impairment induced by hypobaric hypoxia.
Simin Zhou, Simin Zhou, Simin Zhou, Zhifeng Zhong, Zhifeng Zhong, Zhifeng Zhong, Pei Huang, Pei Huang, Pei Huang, Bin Xiang, Bin Xiang, Bin Xiang, Xiaoxu Li, Xiaoxu Li, Xiaoxu Li, Huaping Dong, Huaping Dong, Huaping Dong, Gang Zhang, Gang Zhang, Gang Zhang, Yu Wu, Yu Wu, Yu Wu, Peng Li, Peng Li, Peng Li   +26 more
doaj   +1 more source

Identification of a miRNA–mRNA Regulatory Networks in Placental Tissue Associated With Tibetan High Altitude Adaptation

Frontiers in Genetics, 2021
The Tibetan population has lived and successfully reproduced at high altitude for many generations. Studies have shown that Tibetans have various mechanisms for protection against high-altitude hypoxia, which are probably due, at least in part, to ...
Noryung Tenzing, Noryung Tenzing, Noryung Tenzing, Martha Tissot van Patot, Huifang Liu, Huifang Liu, Huifang Liu, Qiying Xu, Qiying Xu, Qiying Xu, Juanli Liu, Juanli Liu, Juanli Liu, Zhuoya Wang, Zhuoya Wang, Zhuoya Wang, Yanjun Wang, Yanjun Wang, Yanjun Wang, Tana Wuren, Tana Wuren, Ri-Li Ge, Ri-Li Ge   +22 more
doaj   +1 more source

5-Hydroxytryptamine receptor 1D overexpression exacerbates gastric cancer proliferation, invasion, and angiogenesis by activating the Wnt/β-catenin signaling

BMC Cancer
Dysregulation of 5-Hydroxytryptamine and its receptors play important roles in the development and progression of malignant tumors. However, the biological role and underlying molecular mechanism of 5-Hydroxytryptamine Receptor 1D (HTR1D) gastric cancer (
Juan Wu, Yi Yi, Qi Wang, Jinwan Qiao, Haixiu Ma, Jing Zhao, Ronghua Ma, Jun Liu, Haiyan Wang, Zhanhai Su   +9 more
doaj   +1 more source