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Altitude hypoxia and hypoxemia: pathogenesis and management [PDF]

Signal Transduction and Targeted Therapy
At high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which leads to decreased oxygen availability and a ...
Chunmei Cai, Guohua Ni, Lei Chen, Cheng Deng, Shengjun Chai, Rui Wang, Rong Zhang, Fengming Luo, Ri-Li Ge   +8 more
doaj   +2 more sources

Prevalence of gallstone disease and its association with altitude and ethnicity among employee health check-upers in the Qinghai-Tibet Plateau [PDF]

BMC Gastroenterology
Objective This study aimed to investigate the prevalence of gallstone disease among health check-upers (employees) in the Qinghai-Tibet Plateau and clarify the independent effects of altitude, ethnicity, and their interaction on gallstone disease risk ...
Shenggui Qi, Li Li, Yuhua Yan, Gengdeng, Xiaofeng Ma, Airong Yang, Hongguang Fan   +6 more
doaj   +2 more sources

The mudflow dynamics of the river Gerkhozhan-Su in the section of the mudflow tray and mudslides protection of the city of Tyrnyauz (Central Caucasus) [PDF]

E3S Web of Conferences, 2020
Based on the data of route inspection and video surveillance of the mudslides of the river Gerkhozhan-Su have been determined the features of the mudslides dynamics in the section of the mudflow tray.
Dokukin Mikhail, Bekkiev Mukhtar, Kalov Ruslan, Hadjiev Mukhtar   +3 more
doaj   +1 more source

A Vision and Framework for the High Altitude Platform Station (HAPS) Networks of the Future [PDF]

IEEE Communications Surveys and Tutorials, 2020
A High Altitude Platform Station (HAPS) is a network node that operates in the stratosphere at an of altitude around 20 km and is instrumental for providing communication services.
Gunes Karabulut Kurt, M. Khoshkholgh, Safwan Alfattani, Ahmed Ibrahim, Tasneem S. J. Darwish, Md. Sahabul Alam, H. Yanikomeroglu, A. Yongaçoğlu   +7 more
semanticscholar   +1 more source

Molecular Mechanisms of High-Altitude Acclimatization

International Journal of Molecular Sciences, 2023
High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric hypoxia and curtail the development of HAIs.
R. Mallet, Johannes Burtscher, V. Pialoux, Q. Pasha, Y. Ahmad, G. Millet, M. Burtscher   +6 more
semanticscholar   +1 more source

DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia

Military Medical Research, 2021
Background Studies have revealed the protective effect of DL-3-n-butylphthalide (NBP) against diseases associated with ischemic hypoxia. However, the role of NBP in animals with hypobaric hypoxia has not been elucidated.
Gang Xu, Yi-Kun Shi, Bin-Da Sun, Lu Liu, Guo-Ji E., Shu He, Jian-Yang Zhang, Bao Liu, Qiu Hu, Jian Chen, Yu-Qi Gao, Er-Long Zhang   +11 more
doaj   +1 more source

Global and country-level estimates of human population at high altitude

Proceedings of the National Academy of Sciences of the United States of America, 2021
Estimates of the global population of humans living at high altitude vary widely, and such data at the country level are unavailable. Herein, we use a geographic information system (GIS)-based approach to quantify human population at 500-m elevation ...
J. Tremblay, P. Ainslie
semanticscholar   +1 more source

Oxidative Stress and Diseases Associated with High-Altitude Exposure

Antioxidants, 2022
Several diseases associated with high-altitude exposure affect unacclimated individuals. These diseases include acute mountain sickness (AMS), high-altitude cerebral edema (HACE), high-altitude pulmonary edema (HAPE), chronic mountain sickness (CMS), and,
Eduardo Pena, Samia El Alam, P. Siques, Julio Brito   +3 more
semanticscholar   +1 more source

Impact of High Altitude on Cardiovascular Health: Current Perspectives

Vascular Health and Risk Management, 2021
Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more than 100 million lowlanders visit mountainous areas above 2500 m annually. The interactions between the low barometric pressure and partial pressure of O2, climate,
R. Mallet, Johannes Burtscher, J. Richalet, G. Millet, M. Burtscher   +4 more
semanticscholar   +1 more source

Hypoxia exacerbates intestinal injury and inflammatory response mediated by myeloperoxidase during Salmonella Typhimurium infection in mice

Gut Pathogens, 2023
Background High-altitude exposure can cause oxidative stress damage in the intestine, which leads to increased intestinal permeability and bacterial translocation, resulting in local and systemic inflammation. Control of infection is critically dependent
Qinfang Zhu, Ying Han, Xiaozhou Wang, Ruhan Jia, Jingxuan Zhang, Meiheng Liu, Wei Zhang   +6 more
doaj   +1 more source