Results 31 to 40 of about 350,286 (305)

Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma

Frontiers in Oncology, 2019
Hypoxia is a predominant feature in glioblastoma (GBM) and contributes greatly to its drug resistance. However, the molecular mechanisms which are responsible for the development of the resistant phenotype of GBM under hypoxic conditions remain unclear ...
Yixing Gao, Bao Liu, Bao Liu, Lan Feng, Lan Feng, Binda Sun, Binda Sun, Shu He, Shu He, Yidong Yang, Yidong Yang, Gang Wu, Gang Wu, Guoji E, Guoji E, Chang Liu, Chang Liu, Yuqi Gao, Yuqi Gao, Erlong Zhang, Erlong Zhang, Bo Zhu   +21 more
doaj   +1 more source

Exercise and altitude [PDF]

Postgraduate Medical Journal, 1979
Summary In studies concerned with the performance at high altitude it is often not possible to separate the effects which are due to hypoxia from those associated with the stress of ascent. Some of the basic observations concerning exercise at high altitude are reviewed and a study is described which was designed to simulate the physical
openaire   +2 more sources

Strengthening Altitude Knowledge: A Delphi Study to Define Minimum Knowledge of Altitude Illness for Laypersons Traveling to High Altitude [PDF]

, 2022
Introduction: A lack of knowledge among laypersons about the hazards of high-altitude exposure contributes to morbidity and mortality from acute mountain sickness (AMS), high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE) among ...
Burtscher, M., Swenson, E.R., Dehnert, C., Roach, R.C., Luks, A.M., Sartori, C., Dumont, L., Imray, C., Maggiorini, M., Zafren, K., Berendsen, R.R., Basnyat, B., Richalet, J.-P., Subudhi, A.W., Brugger, H., Bärtsch, P., Sikri, G., Muza, S.R., Anholm, J., Loeppky, J.A., Woods, D.R., Moore, L.G., Grocott, M.P.W., Koehle, M.S., Kayser, B., Honigman, B., Hillebrandt, D., Bloch, K.E., Faulhaber, M., Grissom, C.K., Pun, M., Brodmann, M., Fischer, R., Berger, M.M., Scherrer, U., Gatterer, H., Hackett, P., Thompson, A.A., Gekeler, F., Beidleman, B.A., Auerbach, P.S., Verges, S., Lipman, G.S., Luks, Andrew, Berger, Marc Moritz, Berendsen, Remco R; https://orcid.org/, Faulhaber, M, Dehnert, C, Gekeler, F, Anholm, J, Hillebrandt, D, Burtscher, M, Grocott, M P W, Koehle, M S, Hackett, Peter, Gatterer, H, Auerbach, P S, STAK Plenary Grp, Richalet, J.P., Brodmann, M, Hackett, Peter; https://orcid.org/, Berendsen, Remco, Kayser, Bengt, Bärtsch, Peter, Verges, S, Fischer, R, Grissom, C K, Zafren, Ken, Dumont, L, Beidleman, B A, Berger, Marc Moritz; https://orcid.org/, Luks, Andrew M; https://orcid.org/, Lipman, G S, Honigman, B, Loeppky, J A, Basnyat, Buddha, Kayser, Bengt; https://orcid.org/, Zafren, Ken; https://orcid.org/, Richalet, Jean-Paul, Richalet, Jean-Paul; https://orcid.org/, Brugger, H, et al, Imray, C, Bloch, K E   +83 more
core   +1 more source

Altitude-Induced Sleep Apnea Is Highly Dependent on Ethnic Background (Sherpa Vs. Tamang) [PDF]

, 2022
Heiniger, Grégory, Simon Walbaum, Claudio Sartori, Alban Lovis, Marco Sazzini, Andrew Wellman, and Raphael Heinzer. Altitude-Induced Sleep Apnea Is Highly Dependent on Ethnic Background (Sherpa Vs. Tamang). High Alt Med Biol. 23:165-172, 2022. Rationale:
Heiniger, G., Sartori, C., Lovis, A., Wellman, A., Walbaum, S., Sazzini, M., Heinzer, R., Sartori C., Heiniger G., Walbaum S., Heinzer R., Lovis A., Sazzini M., Wellman A., Claudio Sartori, Marco Sazzini, Raphael Heinzer, Simon Walbaum, Grégory Heiniger, Alban Lovis, Andrew Wellman   +20 more
core   +1 more source

Urbanization and altitude are associated with low kidney function in Peru [PDF]

, 2019
Background: Kidney health needs to be studied in low- and middle-income countries with populations living at high altitude and undergoing urbanization. We studied whether greater level of urbanization was associated with worse kidney function; and higher
Narvaez-Guerra, Offdan, Smeeth, Liam, Carrillo Larco, Rodrigo, Miranda, J Jaime, Bernabe-Ortiz, Antonio, CRONICAS Cohort Study Group, Herrera-Enriquez, Karela, Checkley, William, Gilman, Robert H, Carrillo-Larco, Rodrigo M, Medina-Lezama, Josefina   +10 more
core   +1 more source

Comparison of Simulated High Altitude Pilot Effective Performance Time Between Habitual Smokers and Non-Smokers [PDF]

, 2003
Smoking attenuates the amount of oxygen that diffuses from the lung tissue and oxygenates the blood (Guyton, 1996). High altitudes attenuate the oxygen available for transport to the blood.
James F. Fletcher, Fletcher, James F.
core   +1 more source

IL-6/STAT3 Induced Neuron Apoptosis in Hypoxia by Downregulating ATF6 Expression

Frontiers in Physiology, 2021
Background: Neuron apoptosis, regulated by endoplasmic reticulum (ER) stress in the hippocampus, is an essential factor influencing the cognitive impairment induced by hypobaric hypoxia.
Simin Zhou, Simin Zhou, Simin Zhou, Zhifeng Zhong, Zhifeng Zhong, Zhifeng Zhong, Pei Huang, Pei Huang, Pei Huang, Bin Xiang, Bin Xiang, Bin Xiang, Xiaoxu Li, Xiaoxu Li, Xiaoxu Li, Huaping Dong, Huaping Dong, Huaping Dong, Gang Zhang, Gang Zhang, Gang Zhang, Yu Wu, Yu Wu, Yu Wu, Peng Li, Peng Li, Peng Li   +26 more
doaj   +1 more source

Identification of a miRNA–mRNA Regulatory Networks in Placental Tissue Associated With Tibetan High Altitude Adaptation

Frontiers in Genetics, 2021
The Tibetan population has lived and successfully reproduced at high altitude for many generations. Studies have shown that Tibetans have various mechanisms for protection against high-altitude hypoxia, which are probably due, at least in part, to ...
Noryung Tenzing, Noryung Tenzing, Noryung Tenzing, Martha Tissot van Patot, Huifang Liu, Huifang Liu, Huifang Liu, Qiying Xu, Qiying Xu, Qiying Xu, Juanli Liu, Juanli Liu, Juanli Liu, Zhuoya Wang, Zhuoya Wang, Zhuoya Wang, Yanjun Wang, Yanjun Wang, Yanjun Wang, Tana Wuren, Tana Wuren, Ri-Li Ge, Ri-Li Ge   +22 more
doaj   +1 more source

Rational Tuning of Hygroscopic Oscillation of Stacked Nanoflake Assemblies for Continuous Ambient Energy Harvesting

Advanced Materials, EarlyView.
Stacked nanoflake assembly (SNA) membranes can oscillate autonomously, offering opportunities for soft actuation and energy harvesting. This work uncovers the physical mechanism behind the sustained oscillation of SNA membranes in gradient humidity and identifies three governing dimensionless parameters, enabling rational design for optimizing SNA ...
Zijing Zhang, Jimin Fu, Gesa Zhang, Zhihua Liang, Boxun Zhang, Haimin Yao   +5 more
wiley   +1 more source

Tamper‐Responsive Physical Unclonable Functions via Graphene‐Interlayered Block Copolymer Random Structures

Advanced Materials, EarlyView.
Self‐invalidating multilayer physical unclonable functions (PUFs) integrate fingerprint‐like metal nanopattern bilayers from block copolymer templates with highly reactive reduced graphene oxide (rGO) interlayers. This tamper‐responsive architecture blocks all unauthorized physical and chemical replication attempts while autonomously deactivating ...
Gyu Hui Jo, Dae Hui Park, Jeong‐Ho Jang, Woo Seok Tack, Jin Man Kim, Hak Ki Yu, Hyeong Min Jin, Jang Hwan Kim   +7 more
wiley   +1 more source