Results 31 to 40 of about 279,349 (317)

Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma

open access: yesFrontiers in Oncology, 2019
Hypoxia is a predominant feature in glioblastoma (GBM) and contributes greatly to its drug resistance. However, the molecular mechanisms which are responsible for the development of the resistant phenotype of GBM under hypoxic conditions remain unclear ...
Yixing Gao   +21 more
doaj   +1 more source

Exercise and altitude [PDF]

open access: yesPostgraduate Medical Journal, 1979
Summary In studies concerned with the performance at high altitude it is often not possible to separate the effects which are due to hypoxia from those associated with the stress of ascent. Some of the basic observations concerning exercise at high altitude are reviewed and a study is described which was designed to simulate the physical
openaire   +2 more sources

The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives [PDF]

open access: yes, 2019
In contrast to Andean natives, high altitude Tibetans present with a lower hemoglobin concentration that correlates with reproductive success and exercise capacity.
Dawkins, Tony G.   +10 more
core   +1 more source

Diversity, composition, altitude, and seasonality of high-altitude windborne migrating mosquitoes in the Sahel: Implications for disease transmission [PDF]

open access: yes, 2022
Recent studies have reported Anopheles mosquitoes captured at high-altitude (40–290 m above ground) in the Sahel. Here, we describe this migration modality across genera and species of African Culicidae and examine its implications for disease ...
Linton, Yvonne-Marie   +44 more
core   +1 more source

IL-6/STAT3 Induced Neuron Apoptosis in Hypoxia by Downregulating ATF6 Expression

open access: yesFrontiers in Physiology, 2021
Background: Neuron apoptosis, regulated by endoplasmic reticulum (ER) stress in the hippocampus, is an essential factor influencing the cognitive impairment induced by hypobaric hypoxia.
Simin Zhou   +26 more
doaj   +1 more source

Hematological Risk Factors for High-Altitude Headache in Chinese Men Following Acute Exposure at 3,700 m

open access: yesFrontiers in Physiology, 2017
Background: High-altitude headache (HAH) is a notably common disorder affecting the daily life of travelers ascending to high altitude. Hematological parameters are important clinical examinations for various diseases.
He Huang   +18 more
doaj   +1 more source

On the Circular Altitude of Graphs [PDF]

open access: yesBulletin of the Iranian Mathematical Society, 2020
Peter Cameron introduced the concept of the circular altitude of graphs; a parameter which was shown by Bamberg et al. that provides a lower bound on the circular chromatic number. In this note, we investigate this parameter and show that the circular altitude of a graph is equal to the maximum of circular altitudes of its blocks.
openaire   +2 more sources

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp   +4 more
wiley   +1 more source

Adropin Is a Key Mediator of Hypoxia Induced Anti-Dipsogenic Effects via TRPV4-CamKK-AMPK Signaling in the Circumventricular Organs of Rats

open access: yesFrontiers in Molecular Neuroscience, 2017
Water intake reduction (anti-dipsogenic effects) under hypoxia has been well established, but the underlying reason remains unknown. Our previous report indicated that activated TRPV4 neurons in SFO are associated with anti-dipsogenic effects under ...
Qing-Yuan Huang   +19 more
doaj   +1 more source

Identification of a miRNA–mRNA Regulatory Networks in Placental Tissue Associated With Tibetan High Altitude Adaptation

open access: yesFrontiers in Genetics, 2021
The Tibetan population has lived and successfully reproduced at high altitude for many generations. Studies have shown that Tibetans have various mechanisms for protection against high-altitude hypoxia, which are probably due, at least in part, to ...
Noryung Tenzing   +22 more
doaj   +1 more source

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