Results 151 to 160 of about 331,012 (291)

Transformer‐Based PET/CT Fusion Enables Preoperative Prediction and Prognostic Stratification of Spread Through Air Spaces in Lung Adenocarcinoma

Advanced Science, EarlyView.
An eight‐stream 2.5D Transformer integrates complementary PET metabolic and CT morphologic information to estimate spread‐through‐air‐spaces risk before surgery in lung adenocarcinoma. The model generalizes across independent centers, while its continuous risk score independently stratifies progression‐free survival, supporting further prospective ...
Xin‐Yu Zhu, Meng Meng, Zhen‐Zhen Wang, Deng‐Lu Lu, Ya‐Min Wei, Xu‐Chang Mi, Xing‐Yu Mu, Wei Fu   +7 more
wiley   +1 more source

Cigarette Smoke-Induced Alveolar Macrophage Senescence via GEM/SIRT3-Mediated Mitochondrial Dysfunction. [PDF]

Adv Sci (Weinh)
Wang J, Wei M, Song X, Zhang J, Zhang L, Chen S, Hu Y, Gao H, Li J.   +8 more
europepmc   +1 more source

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

A signal-responsive cooperative transcription factor network determines alveolar macrophage identity. [PDF]

J Exp Med
Mínguez-Martínez J, Porcuna J, Casablanca L, Gómez MJ, Aghelpasand H, Höjer P, García-Fojeda B, Núñez V, Torroja C, Mühleder S, Gustafsson C, Fischer T, Benedito R, Casals C, Månsson R, Sánchez-Cabo F, Ricote M.   +16 more
europepmc   +1 more source

The magnesium-doped CSH/BCP promotes alveolar bone regeneration by mediating M2 macrophage polarization via miR-21–5p/Smad2 axis

The repair of alveolar bone defects is a complex biological process that involves the interplay between implant materials, bone marrow mesenchymal stem cells (BMSCs), and the immune cells present in the surrounding area.
Liu, Y, Yan, T, Xu, J, Ye, Q, Sun, S, Zhou, J, Zhang, L, Liu, C, Zhang, Y, He, Y   +9 more
core   +1 more source

Differential Diagnosis of Mucopolysaccharidoses Types I, II, III, IVA, and VI Through Analysis of Leukocytic Inclusions

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Mucopolysaccharidoses (MPS) are lysosomal storage disorders characterized by the accumulation of glycosaminoglycans (GAGs), which can lead to cytoplasmic alterations in leukocytes. The objective of this study was to characterize leukocyte inclusions in patients with different types of MPS and assess their diagnostic relevance.
Márcio A. W. Melo, Marcelo S. Kertenetzky, Cristina M. Silveira, Maíra M. Ribeiro, Paula F. Medeiros, Gabriela S. Arcanjo   +5 more
wiley   +1 more source

Fatty acid-binding protein 5 deficiency impairs alveolar macrophage function and metabolism. [PDF]

J Lipid Res
Ratliff JH, Aviszus K, Addi S, El Kharbili M, Fujaros S, Sasse SK, Vestal BE, Gerber AN, Dobrinskikh E, Gally F.   +9 more
europepmc   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

CRISPR screening identifies DTX4 governing alveolar macrophage cholesterol efflux in pulmonary alveolar proteinosis. [PDF]

JCI Insight
Wang Z, Shi J, Ye X, Xia X, Zhu H, Li Q, Chen M, Zhao Y, Zhang Y, Cao M, Xiao Y, Huang X.   +11 more
europepmc   +1 more source

Potentiation of Tumor Necrosis Factor-Alpha Expression by Yg-1 in Alveolar Macrophages through a Cyclic Gmp-Independent Pathway

, 2009
Using cultured rat alveolar NR 8383 macrophages, this study investigated the effect of YC-1 [3-(5'-hydroxymethyl-2-furyl )-1-benzyI indazole], a soluble guanylyl cyclase (sGC) activator, on the production of tumor necrosis factor-alpha( TNFalpha).
GUH, JIH-HWA;TENG, CHE-MING, 顧記華;鄧哲明   +1 more
core