Results 81 to 90 of about 331,012 (291)

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Alveolar macrophages: guardians of the alveolar lipid galaxy

Current Opinion in Lipidology
Purpose of review As the primary guardians at the air-surface interface, the functional profile of alveolar macrophages (AM) is wide-ranging from establishment of the alveolar niche, homeostatic maintenance of surfactant levels, to pathogen clearance and resolution and repair processes.
Little, Isaiah, Bersie, Stephanie, Redente, Elizabeth F., McCubbrey, Alexandra L., Tarling, Elizabeth J.   +4 more
openaire   +2 more sources

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Macrophage-Derived Exosomal BMPR2 Mediates Alveolar Epithelial Repair and Cellular Crosstalk in Acute Lung Injury [PDF]

Xiang Yun,1– 3 Fei Li,1 Zhen Chen,4 Jiahua Meng,1 Lin Zhang,2,3,5 Juxiang Yuan1 1School of Public Health, North China University of Science and Technology, Tangshan, 063000, People’s Republic of China; 2Clinical Medical Research Center for Women and ...
Chen Z, Yun X, Li F, Zhang L, Meng J, Yuan J   +5 more
core  

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Epigenetic mechanisms of alveolar macrophage activation in chemical-induced acute lung injury

Frontiers in Immunology
Airways, alveoli and the pulmonary tissues are the most vulnerable to the external environment including occasional deliberate or accidental exposure to highly toxic chemical gases.
Shama Ahmad, Wesam Nasser, Aftab Ahmad
doaj   +1 more source

Cellulose nanocrystals modulate alveolar macrophage phenotype and phagocytic function [PDF]

, 2019
Nanocellulose is a promising bio-nanomaterial with attractive properties suitable for multiple industrial applications. The increased use of nanocellulose may lead to occupational exposure and negative health outcomes.
Samulin-Erdem, Johanna Maria, Alswady-Hoff, Mayes, Ervik, Torunn Kringlen, Ellingsen, Dag, Zienolddiny, Shanbeh, Skare, Øivind   +5 more
core   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus.

PLoS Pathogens, 2005
Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage recognition receptor is critical for innate immunity to A ...
Chad Steele, Rekha R Rapaka, Allison Metz, Shannon M Pop, David L Williams, Siamon Gordon, Jay K Kolls, Gordon D Brown   +7 more
doaj   +2 more sources

Exogenous Nitric Oxide Ameliorates Macrophage-Mediated Periodontal Inflammation

International Dental Journal
Aim or purpose: The nitric oxide (NO) is a reactive nitrogen species closely related to the periodontitis treatment. This study aims to investigate the roles and regulatory mechanisms of exogenous NO from cold atmospheric plasma (CAP) in modulating ...
Zhixin Liu, Laidi Wu, Chengbo Yu, Yingguang Cao, Ke Song   +4 more
doaj   +1 more source