Results 61 to 70 of about 331,012 (291)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

Advanced Science
We established robust protocols to generate physiological and functional alveolar organoids (nsoAlvO) from readily accessible and expandable nasal cell‐derived organoids, and alveolar macrophages (monoAM) from peripheral blood monocytes.
Man Chun Chiu, Shuxin Zhang, Cun Li, Yifei Yu, Zhixin Wan, Jingjing Huang, Wei Xue, Ying Zhou, Xiaoxin Zhu, Qiaoshuai Lan, Jiali Wu, Zijun Zhao, Yuhong Liu, Xinjie Meng, Lin Huang, Hin Chu, Honglin Chen, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +19 more
doaj   +1 more source

Neutrophil Extracellular Traps Augmented Alveolar Macrophage Pyroptosis via AIM2 Inflammasome Activation in LPS-Induced ALI/ARDS

Journal of Inflammation Research, 2021
Haitao Li,1 Yi Li,2 Chao Song,2 Yongbin Hu,3 Minhui Dai,2 Ben Liu,4 Pinhua Pan2 1First Department of Thoracic Medicine, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha City, Hunan ...
Li H, Li Y, Song C, Hu Y, Dai M, Liu B, Pan P   +6 more
doaj  

Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function

Cell Reports, 2018
Summary: The rapid transit from hypoxia to normoxia in the lung that follows the first breath in newborn mice coincides with alveolar macrophage (AM) differentiation.
Helena M. Izquierdo, Paola Brandi, Manuel-José Gómez, Ruth Conde-Garrosa, Elena Priego, Michel Enamorado, Sarai Martínez-Cano, Iria Sánchez, Laura Conejero, Daniel Jimenez-Carretero, Silvia Martín-Puig, Martin Guilliams, David Sancho   +12 more
doaj   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

DataSheet_1_Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction.pdf

, 2023
Respiratory disorders caused by allergy have been associated to bronchiolar inflammation leading to life-threatening airway narrowing. However, whether airway allergy causes alveolar dysfunction contributing to the pathology of allergic asthma remains ...
Lidia Feo-Lucas, Laura H. Villarrubia (15443552), Leticia González-Cintado (105447), Cristina Godio, Lidia Feo-Lucas (15443543), Carlos Montero-Fernández, Natalia Alvarez-Ladrón (15443549), María López-Bravo, Chiara Autilio, Adrián Vega-Pérez, Jorge Domínguez-Andrés, María Minguito de la Escalera (15443546), Andrés Hidalgo (5270033), Cristina Casals (152439), Natalia Alvarez-Ladrón, Belén García-Fojeda, Andrés Hidalgo, María López-Bravo (15443558), Georgiana Crainiciuc (15443555), Cristina Casals, Jesús Pérez-Gil, Jorge Domínguez-Andrés (4443055), Belén García-Fojeda (5712623), Leticia González-Cintado, Cristina Godio (2400838), Carlos Montero-Fernández (12340831), Jesús Pérez-Gil (152437), Carlos Ardavín, María Minguito de la Escalera, Laura H. Villarrubia, Carlos Ardavín (105461), Adrián Vega-Pérez (7024037), Georgiana Crainiciuc, Chiara Autilio (4840086)   +33 more
core   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

hPDLSC-ApoEVs attenuate periodontitis and enhance bone regeneration via NF-κB/S100A9-Mediated M2 macrophage polarization

Stem Cell Research & Therapy
Background Periodontitis is the most prevalent oral disease worldwide, leading to inflammation, alveolar bone loss, and tooth loss. Mesenchymal stem cells (MSCs) transplantation has the potential to alleviate periodontitis and restore alveolar bone, but ...
Zeyu Zhang, Liting Zeng, Yang Yu, Zidan Xu, Guanxiong Zhu, Jinlong Weng, Junyi Xia, Weijie Peng, Qin Dong, Yuanyuan Li, Lingmin Zhang, Lu Liang, Janak Lal Pathak, Lina Yu   +13 more
doaj   +1 more source

ETHANOL EXTRACT OF MANGOSTEEN PEEL REDUCES HISTOLOGICAL COUNT OF ALVEOLAR MACROPHAGE AND PULMONARY ALVEOLAR SPACE SIZE IN MALE WHITE RATS (Rattus norvegicus) EXPOSED TO CIGARETTE SMOKE

Folia Medica Indonesiana, 2016
This study aims to analyze histological alveolar macrophage cell number and width of pulmonary alveolar space white male rats given ethanol extract of mangosteen peel and then exposed to cigarette smoke.
Anna Lewi Santoso
doaj   +1 more source