Results 51 to 60 of about 331,012 (291)

Generation of induced alveolar assembloids with functional alveolar-like macrophages

Nature Communications
Within the human lung, interactions between alveolar epithelial cells and resident macrophages shape lung development and function in both health and disease.
Ji Su Kang, Youngsun Lee, Youngsun Lee, Dayeon Gil, Min Jung Kim, Connor Wood, Vincent Delorme, Jeong Mi Lee, Kyong-Cheol Ko, Jung-Hyun Kim, Mi-Ok Lee   +10 more
doaj   +1 more source

C/EBPβ deletion in macrophages impairs mammary gland alveolar budding during the estrous cycle

Life Science Alliance
Macrophage C/EBPβ contributes to alveolar budding during the estrous cycle by providing critical signaling to mammary epithelial cells. Macrophages have important roles in mammary gland development and tissue homeostasis, but the specific mechanisms that
Michelle D Rojo, Ishitri Bandyopadhyay, Caitlin M Burke, Alexa D Sturtz, Emily S Phillips, Megan G Matherne, Samuel J Embrey, Rebecca LaRue, Yinjie Qiu, Kathryn L Schwertfeger, Heather L Machado   +10 more
doaj   +1 more source

HYALURONIDASE ACTIVITY OF ALVEOLAR MACROPHAGES [PDF]

Journal of Histochemistry & Cytochemistry, 1968
Hyaluronidase activity was detected in preparations of isolated rabbit lung alveolar macrophages. The enzyme manifested a pH optimum of 3.9 with no activity detected above pH 5. Analysis of reaction products isolated from digests containing low enzyme concentrations revealed the production of large oligosaccharides from hyaluronic acid without the ...
J F, Goggins, G S, Lazarus, H M, Fullmer
openaire   +2 more sources

Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free‐Moving Mice

Advanced Healthcare Materials, EarlyView.
Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu, Cort Thompson, Thomas Deakin, Yan Xu, Colleen A. McClung, Xinyan Tracy Cui   +5 more
wiley   +1 more source

Impaired Innate COPD Alveolar Macrophage Responses and Toll-Like Receptor-9 Polymorphisms. [PDF]

PLoS ONE, 2015
Dysfunctional innate responses of alveolar macrophages to nontypeable Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae contribute to morbidity in chronic obstructive pulmonary disease (COPD).
Charles S Berenson, Ragina L Kruzel, Catherine T Wrona, Manoj J Mammen, Sanjay Sethi   +4 more
doaj   +1 more source

A Hybrid Bioprinting–Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity

Advanced Healthcare Materials, EarlyView.
This work introduces a “cancer‐in‐a‐well” technology that recreates tumor heterogeneity in vitro using multitype spheroid arrays. Combining bioprinting/microdispensing with microstructured culture devices, the system improves drug screening and modeling of tumor complexity.
Simone Bonetti, Eva Clemente, Emanuela Mensà, Marco de Maria, Fulvia Farabegoli, Emanuela Saracino, Barbara Bortolani, Emanuela Marcelli, Renato Brandimarti, Dario de Biase, Giampaolo Zuccheri   +10 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi

Respiratory Research, 2017
Background Non-typeable Haemophilus influenza (NTHi) infection is common in COPD. Corticosteroids can have limited therapeutic effects in COPD patients. NTHi causes corticosteroid insensitive cytokine production from COPD alveolar macrophages.
Rana M. Khalaf, Simon R. Lea, Hannah J. Metcalfe, Dave Singh   +3 more
doaj   +1 more source

Lung microhaemorrhage drives oxidative/inflammatory damage in α1-antitrypsin deficiency

ERJ Open Research, 2023
Background Animal models using intratracheal instillation show that elastase, unopposed by α1-antitrypsin (AAT), causes alveolar damage and haemorrhage associated with emphysematous changes.
Cesare Saltini, Naweed Mohammad, Yan Xin, Rodolfo Alvarado, Andrew J. Ghio, Craig G. Moneypenny, Alberto Riva, Dongtao Fu, Tammy Flagg, Giovanni F.A. Saltini, Ivan Arisi, Kristianna M. Fredenburg, Yang Zhang, Jorge E. Lascano, Mark Brantly   +14 more
doaj   +1 more source