Results 81 to 90 of about 1,184,873 (292)

Chemiluminescence of asbestos-activated macrophages [PDF]

, 1984
Chemiluminescence, a measure of reactive oxygen release by phagocytes, was compared in peritoneal exudate macrophages elicited with chrysotile asbestos, Corynebacterium parvum and saline. Chrysotile asbestos- and C.
Cullen, R T, Donaldson, Ken
core  

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation [PDF]

, 2012
Influenza virus infection accounts for significant morbidity and mortality world-wide. Interactions of the virus with host cells, particularly those of the macrophage lineage, are thought to contribute to various pathological changes associated with poor
Jackson David, Richard E. Randall, Richard E. Randall (190211), Nash, A.A., Anthony A Nash, Hoeve, M.A., Marieke A Hoeve, Anthony A. Nash, Hoeve Marieke A., Nash, Anthony A., Dransfield, I., Marieke A. Hoeve (190207), David Jackson (84936), Richard E Randall, Randall Richard E., Jackson, David, Randall, R.E., Nash Anthony A., David Jackson, Jackson, D., Ian Dransfield (190213), Dransfield, Ian, Marieke A. Hoeve, Anthony A. Nash (190209), Randall, Richard E., Ian Dransfield, Hoeve, Marieke A., Dransfield Ian   +27 more
core   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Functional consequences for primary human alveolar macrophages following treatment with long, but not short, multiwalled carbon nanotubes [PDF]

, 2015
Sinbad Sweeney, Davide Grandolfo, Pakatip Ruenraroengsak, Teresa D TetleyLung Cell Biology, Section of Pharmacology and Toxicology, National Heart and Lung Institute, Imperial College London, London, UKPurpose: Multiwalled carbon nanotubes (MWCNTs ...
Grandolfo, D, Tetley TD, Ruenraroengsak, P, Sweeney, S, Tetley, TD, Sweeney S, Grandolfo D, Ruenraroengsak P   +7 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Human alveolar macrophages predominately express combined classical M1 and M2 surface markers in steady state

Respiratory Research, 2018
Alveolar macrophages (AM) are critical to the homeostasis of the inflammatory environment in the lung. Differential expression of surface markers classifies macrophages to either classically (M1) or alternatively activated (M2).
E. Mitsi, R. Kamng'ona, J. Rylance, C. Solórzano, J. Reiné, H. Mwandumba, D. Ferreira, Kondwani C. Jambo   +7 more
semanticscholar   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Epigenetic mechanisms of alveolar macrophage activation in chemical-induced acute lung injury

Frontiers in Immunology
Airways, alveoli and the pulmonary tissues are the most vulnerable to the external environment including occasional deliberate or accidental exposure to highly toxic chemical gases.
Shama Ahmad, Wesam Nasser, Aftab Ahmad
doaj   +1 more source