Results 61 to 70 of about 1,184,873 (292)

Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19

Nature Immunology
Monocyte-derived alveolar macrophages drive lung injury and fibrosis in murine models and are associated with pulmonary fibrosis in humans. Monocyte-derived alveolar macrophages have been suggested to develop a phenotype that promotes lung repair as ...
J. Bailey, C. Puritz, Karolina J. Senkow, N. Markov, Estefani Diaz, E. Jonasson, Zhan Yu, S. Swaminathan, Ziyan Lu, S. Fenske, R. Grant, H. Abdala-Valencia, Ruben J. Mylvaganam, A. Ludwig, Janet Miller, R. Cumming, R. Tighe, K. Gowdy, R. Kalhan, M. Jain, A. Bharat, C. Kurihara, Rúben San José Estépar, Raúl San José Estépar, G. Washko, A. Shilatifard, J. I. Sznajder, K. Ridge, G. R. Scott Budinger, Rosemary Braun, A. Misharin, M. A. Sala   +31 more
semanticscholar   +1 more source

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

European Respiratory Journal, 2019
Ontologically distinct populations of macrophages differentially contribute to organ fibrosis through unknown mechanisms. We applied lineage tracing, single-cell RNA sequencing and single-molecule fluorescence in situ hybridisation to a spatially ...
Nikita Joshi, S. Watanabe, R. Verma, R. Jablonski, Ching‐I Chen, P. Cheresh, N. Markov, P. Reyfman, Alexandra C. McQuattie-Pimentel, L. Sichizya, Ziyan Lu, Raul Piseaux-Aillon, David Kirchenbuechler, A. S. Flozak, C. Gottardi, C. Cuda, H. Perlman, M. Jain, D. Kamp, G. R. Scott Budinger, A. Misharin   +20 more
semanticscholar   +1 more source

Probing Host Pathogen Cross-Talk by Transcriptional Profiling of Both Mycobacterium tuberculosis and Infected Human Dendritic Cells and Macrophages. [PDF]

, 2008
BACKGROUND: Transcriptional profiling using microarrays provides a unique opportunity to decipher host pathogen cross-talk on the global level. Here, for the first time, we have been able to investigate gene expression changes in both Mycobacterium ...
Waddell, Simon, Castagnoli, PR, Mattia Pelizzola (20247), Castagnoli, Paola Ricciardi, Pelizzola Mattia, Foti, M, Maria Foti, Butcher, Philip, Neyrolles, Olivier, Neyrolles, O, Antoine Tanne, Simon J Waddell, Olivier Neyrolles, Pelizzola, M, Tailleux, L, Simon J. Waddell, Antoine Tanne (272975), Philip D Butcher (16047203), Maria Foti (20249), Neil G. Stoker, Stoker Neil G., Waddell, SJ, Tailleux Ludovic, Tailleux, Ludovic, Gicquel, Brigitte, Simon Waddell (4462816), Castagnoli Paola Ricciardi, Brigitte Gicquel, Philip D Butcher, Tanne Antoine, Alessandra Mortellaro (272973), Mortellaro, A, Gicquel Brigitte, Stoker, Neil, Philip D. Butcher, Butcher, PD, Tanne, Antoine, Olivier Neyrolles (72204), Tanne, A, Mortellaro, Alessandra, Paola Ricciardi Castagnoli (16048310), Ludovic Tailleux, Michael Withers (272974), Neyrolles Olivier, Withers Michael, Foti, Maria, Waddell Simon J., Stoker, NG, Michael Withers, Pelizzola, Mattia, Mortellaro Alessandra, Brigitte Gicquel (31454), Ludovic Tailleux (72195), Neil G Stoker (16048313), Alessandra Mortellaro, Neil G Stoker, Foti Maria, Gicquel, B, Butcher Philip D., Withers, M, Mattia Pelizzola, Paola Ricciardi Castagnoli, Withers, Michael   +62 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Advanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey   +9 more
wiley   +1 more source

Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in IL-1/LPS-Insufflated Rats. [PDF]

PLoS ONE, 2015
Glutamine (GLN) attenuates acute lung injury (ALI) but its effect on alveolar macrophages is unknown. We hypothesized that GLN pretreatment would induce the anti-inflammatory CD163/heme oxygenase (HO)-1/p38-MAPK dephosphorylation pathway in alveolar ...
Ana Fernandez-Bustamante, Amanda Agazio, Paul Wilson, Nancy Elkins, Luke Domaleski, Qianbin He, Kaily A Baer, Angela F D Moss, Paul E Wischmeyer, John E Repine   +9 more
doaj   +1 more source

Alveolar macrophages generate a non-canonical NRF2-driven transcriptional response to Mycobacterium tuberculosis in vivo

Science immunology, 2019
Induction of an NRF2-dependent cell-protective signature impairs alveolar macrophages from controlling M.tb. infection in vivo. Interfering with macrophage activation One of the many reasons for Mycobacterium tuberculosis (M.tb.) persistence is that the ...
Alissa C. Rothchild, G. S. Olson, J. Nemeth, Lynn M. Amon, D. Mai, E. Gold, A. Diercks, A. Aderem   +7 more
semanticscholar   +1 more source

Local lung responses following endobronchial elastase and lipopolysaccharide instillation in sheep [PDF]

, 2006
Chronic lipopolysaccharide (LPS) exposure may contribute to the pathogenesis of a number of lung diseases including COPD and emphysema. We sought to develop a large-animal model of emphysema using repeated LPS administration into sheep lung segments.
Blundell, Richard, Rhind, Susan; id_orcid, McLean, Nicola, Rhind, Susan, Milne, Elspeth, Woodall, Chris, Collie, D David S, Baker, Alison, Sallenave, Jean-Michel   +8 more
core   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source