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Network: Computation in Neural Systems, 2011 Over the last three decades, advances in biochemical pathology and human genetics have illuminated one of the most enigmatic subjects in biomedicine--neurodegeneration. Eponymic diseases of the nervous system such as Alzheimer's, Parkinson's, and Huntington's diseases that were long characterized by mechanistic ignorance have yielded striking progress ...
D. Selkoe
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Lecanemab in Early Alzheimer's Disease.
New England Journal of Medicine, 2022 BACKGROUND The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer's disease.
C. V. van Dyck +18 more
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Neurobiology of Disease, 2000 Use of valid diagnostic criteria is extremely important in the recognition of Alzheimer's disease (AD). Patients with mild to moderate Alzheimer's disease should be started on a cholinesterase inhibitor and possibly anti-inflammatory agents, antioxidants (vitamin E or selegiline), and estrogen replacement therapy (for postmenopausal women).
, Schachter, , Davis
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2023 Alzheimer's disease facts and figures
Alzheimer's & Dementia, 2023 This article describes the public health impact of Alzheimer's disease, including prevalence and incidence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society.
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Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023 Introduction The study examined Black and White prospective participants’ views of barriers to and facilitators of participation in Alzheimer's disease (AD) biomarker research.
Johanne Eliacin +12 more
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iScience, 2021 Summary: It has been suggested that aberrant activation of glycogen synthase kinase-3-beta (GSK-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in Alzheimer ...
Ana Claudia Amaral +15 more
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Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023 Introduction Acculturation‐related characteristics, that is, factors directly connected to culture and familial relationships, are associated with engaged research participation within Latino communities.
Melissa Lamar +6 more
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Health Science Reports, 2022 Background and Aims Alzheimer's disease (AD) is the main cause of dementia and over the 55 million people live with dementia worldwide. We aimed to establish the first database called the Iranian Alzheimer's Disease Registry to create a powerful source ...
Javad Fahanik‐Babaei +19 more
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Neuropsychiatric symptoms in Brazilians with mild cognitive impairment and dementia
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021 Introduction Knowledge is limited about behavioral and psychological symptoms of mild cognitive impairment (MCI) and dementia in racial and ethnic minorities.
Robert S. Wilson +6 more
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Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markers
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Fasting glucose increases with age and is linked to modifiable Alzheimer's disease risk factors such as cardiovascular disease and Type 2 diabetes (T2D).
Robyn A. Honea +9 more
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