A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's
ABSTRACT There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, finding that NfL demonstrates high prognostic value and distinct ...
Natalia E. Owen+8 more
wiley +1 more source
Deep Learning in Early Alzheimer's disease's Detection: A Comprehensive Survey of Classification, Segmentation, and Feature Extraction Methods [PDF]
Alzheimers disease is a deadly neurological condition, impairing important memory and brain functions. Alzheimers disease promotes brain shrinkage, ultimately leading to dementia. Dementia diagnosis typically takes 2.8 to 4.4 years after the first clinical indication.
arxiv
Evidence for early identification of Alzheimer's disease [PDF]
Alzheimer's disease is a human brain disease that affects a significant fraction of the population by causing problems with short-term memory, thinking, spatial orientation and behavior, memory loss and other intellectual abilities. Up to date there is no singular test that can definitively diagnose Alzheimer's disease, although imaging technology ...
arxiv
ALTERED CHROMATIN CONFORMATION IN ALZHEIMER'S DISEASE [PDF]
D. R. Crapper+2 more
openalex +1 more source
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi+4 more
wiley +1 more source
3D Inception-based CNN with sMRI and MD-DTI data fusion for Alzheimer's Disease diagnostics [PDF]
In the last decade, computer-aided early diagnostics of Alzheimer's Disease (AD) and its prodromal form, Mild Cognitive Impairment (MCI), has been the subject of extensive research. Some recent studies have shown promising results in the AD and MCI determination using structural and functional Magnetic Resonance Imaging (sMRI, fMRI), Positron Emission ...
arxiv
Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine
Chiral engineered biomaterials can selectively influence cell behaviors in regenerative medicine. This review covers chiral engineered biomaterials in terms of their fabrication methods, cellular response mechanisms, and applications in directing stem cell differentiation and tissue function.
Yuwen Wang+5 more
wiley +1 more source
A Comprehensive Comparison Between ANNs and KANs For Classifying EEG Alzheimer's Data [PDF]
Alzheimer's Disease is an incurable cognitive condition that affects thousands of people globally. While some diagnostic methods exist for Alzheimer's Disease, many of these methods cannot detect Alzheimer's in its earlier stages. Recently, researchers have explored the use of Electroencephalogram (EEG) technology for diagnosing Alzheimer's.
arxiv
3D CNN-based classification using sMRI and MD-DTI images for Alzheimer disease studies [PDF]
Computer-aided early diagnosis of Alzheimers Disease (AD) and its prodromal form, Mild Cognitive Impairment (MCI), has been the subject of extensive research in recent years. Some recent studies have shown promising results in the AD and MCI determination using structural and functional Magnetic Resonance Imaging (sMRI, fMRI), Positron Emission ...
arxiv