Results 11 to 20 of about 368,637 (232)

Identification of gene pathways implicated in Alzheimer's disease using longitudinal imaging phenotypes with sparse regression [PDF]

, 2012
We present a new method for the detection of gene pathways associated with a multivariate quantitative trait, and use it to identify causal pathways associated with an imaging endophenotype characteristic of longitudinal structural change in the brains ...
Alzheimer's Disease Neuroimaging Initiative, Hua, Xue, Janousova, Eva, Montana, Giovanni, Silver, Matt, Thompson, Paul M   +5 more
core   +2 more sources

NETosis in Alzheimer’s Disease [PDF]

Frontiers in Immunology, 2017
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions. Its neuropathological features include amyloid-β (Aβ) accumulation, the formation of neurofibrillary tangles, and the loss of neurons and synapses.
Pietronigro, Enrica Caterina, DELLA BIANCA, Vittorina, ZENARO, Elena, CONSTANTIN, Gabriela   +3 more
openaire   +4 more sources

Metals in Alzheimer’s Disease

Biomedicines, 2023
The role of metals in the pathogenesis of Alzheimer’s disease (AD) is still debated. Although previous research has linked changes in essential metal homeostasis and exposure to environmental heavy metals to the pathogenesis of AD, more research is needed to determine the relationship between metals and AD.
Mirjana Babić Leko, Lea Langer Horvat, Ena Španić Popovački, Klara Zubčić, Patrick R. Hof, Goran Šimić   +5 more
openaire   +4 more sources

Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. [PDF]

, 2012
Tauopathies are widespread neurodegenerative disorders characterised by the intracellular accumulation of hyperphosphorylated tau. Especially in Alzheimer's disease, pathological alterations in the retina are discussed as potential biomarkers to improve ...
Arzberger, Thomas, Burgold, Steffen, Filser, Severin, Goedert, Michel, Herms, Jochen, Hoffmann, Nadine A., Kretzschmar, Hans A., Ochs, Simon M., Schmidt, Boris, Schön, Christian, Seeliger, Mathias W., Steinbach, Sonja   +11 more
core   +8 more sources

Bayesian latent time joint mixed-effects model of progression in the Alzheimer's Disease Neuroimaging Initiative. [PDF]

, 2018
IntroductionWe characterize long-term disease dynamics from cognitively healthy to dementia using data from the Alzheimer's Disease Neuroimaging Initiative.MethodsWe apply a latent time joint mixed-effects model to 16 cognitive, functional, biomarker ...
Aisen, Paul S, Donohue, Michael C, Iddi, Samuel, Li, Dan, Rafii, Michael S, Thompson, Wesley K   +5 more
core   +1 more source

Microbes and Alzheimer’s Disease

Journal of Alzheimer's Disease, 2016
descripción no proporcionada por ...
Judith A. Whittum-Hudson, Angela R. Kamer, Claudio Grassi, Luc Letenneur, Alan P. Hudson, Kelly Del Tredici, Naji Tabet, Jürgen Haas, Hugo Lövheim, Ruth F. Itzhaki, Ruth F. Itzhaki, Chris M. Preston, Brian J. Balin, María J. Bullido, Elaine L. Bearer, Tamas Fulop, Roberta Mancuso, Simon D. Taylor-Robinson, Richard Lathe, Anna Teresa Palamara, George Perry, Timo E. Strandberg, Carola Otth, Heiko Braak, Mario Clerici, S. Louise Cosby, Judith Miklossy, C.J. Carter, Federico Licastro, W. Sue T. Griffin, Etheresia Pretorius, Hugh J. Field, Melvyn J. Ball, Douglas B. Kell   +33 more
openaire   +11 more sources

On the reconceptualization of Alzheimer’s disease [PDF]

Bioethics, 2018
AbstractIn the hope of future treatments to prevent or slow down the disease, there is a strong movement towards an ever‐earlier detection of Alzheimer’s disease (AD). In conjunction with scientific developments, this has prompted a reconceptualization of AD, as a slowly progressive pathological process with a long asymptomatic phase. New concepts such
Maartje H. N. Schermer, Edo Richard
openaire   +6 more sources

Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease. [PDF]

, 2017
The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism.
Alkallas, Rached, Fish, Lisa, Goodarzi, Hani, Najafabadi, Hamed S   +3 more
core   +3 more sources

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. [PDF]

, 2012
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease.
Bardy, Cedric, Boscolo, Francesca S, Carson, Christian T, Gage, Fred H, Goldstein, Lawrence SB, Hefferan, Michael P, Herrera, Cheryl, Israel, Mason A, Koo, Edward H, Laurent, Louise C, Marsala, Martin, Mu, Yangling, Nazor, Kristopher L, Remes, Anne M, Reyna, Sol M, Van Gorp, Sebastiaan, Yuan, Shauna H   +16 more
core   +3 more sources

The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease. [PDF]

, 2019
IntroductionClinical trials on preclinical Alzheimer's disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more ...
Aisen, Paul S, Donohue, Michael C, Iddi, Samuel, Li, Dan, Thompson, Wesley K   +4 more
core   +1 more source