Results 21 to 30 of about 9,770,551 (325)

Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report. [PDF]

, 2019
We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after the expected age of clinical onset.
A Butler, A Lalazar, A Llado, Aaron P. Schultz, Ana Baena, Arabiye Artola, AS Fleisher, Claudia Marino, D Smedley, Daniel J. Norton, David Aguillon, David Leyton-Cifuentes, DC Aguirre-Acevedo, Dhanesh Amarnani, DM Walsh, DT Chien, E Hudry, EC Mormino, Edmarie Guzmán-Vélez, EH Corder, Enmanuelle Pardilla-Delgado, Eric M. Reiman, Francisco Lopera, Gyungah R. Jun, H Braak, H Braak, Henrik Zetterberg, J Logan, JA Becker, Ji Luo, JI Velez, Jianling Ji, JN Rauch, John B. Miller, Joseph F. Arboleda-Velasquez, Juliana Acosta-Uribe, Justin S. Sanchez, KA Johnson, Kahira L. Saez-Torres, Kaj Blennow, Keith A. Johnson, Kenneth S. Kosik, Kewei Chen, L Wang, L Zhong, Leo A. Kim, Lishuang Shen, M Futamura, M Gisslén, MA Lalli, Marcus Naymik, Margarita Giraldo, Matthew J. Huentelman, Matthew Lalli, Michael O’Hare, Moiz Bootwalla, MR Wardell, N Acosta-Baena, Natalia Chmielewska, O Preische, Pierre N. Tariot, Pradeep Thiyyagura, Rebecca A. Reiman, Reisa A. Sperling, RW Mahley, S Fisher, S Thordardottir, Santiago Delgado-Tirado, Silvia Rios-Romenets, T Hashimoto, T Hashimoto, T Hedden, TM Shoup, WD Knight, Xiaowu Gai, Y Yamauchi, Yakeel T. Quiroz, Yi Su, Yinghua Chen, YT Quiroz   +79 more
core   +3 more sources

Early affective changes and increased connectivity in preclinical Alzheimer's disease. [PDF]

, 2018
IntroductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli.
Bilgel, Murat, Brown, Jesse A, Fredericks, Carolyn A, Hua, Alice Y, Resnick, Susan M, Seeley, William W, Sturm, Virginia E, Wong, Dean F   +7 more
core   +1 more source

Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Federally funded Alzheimer's Disease Centers in the United States have been using a standardized neuropsychological test battery as part of the National Alzheimer's Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the
Hiroko H. Dodge, Felicia C. Goldstein, Nicole I Wakim, Tamar Gefen, Merilee Teylan, Kwun C.G. Chan, Walter A. Kukull, Lisa L. Barnes, Bruno Giordani, Timothy M. Hughes, Joel H. Kramer, David A. Loewenstein, Daniel C. Marson, Dan M. Mungas, Nora Mattek, Bonnie C. Sachs, David P. Salmon, Monica Willis‐Parker, Kathleen A. Welsh‐Bohmer, Katherine V. Wild, John C. Morris, Sandra Weintraub, National Alzheimer's Coordinating Center (NACC)   +22 more
doaj   +1 more source

Deep learning improves utility of tau PET in the study of Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction Positron emission tomography (PET) imaging targeting neurofibrillary tau tangles is increasingly used in the study of Alzheimer's disease (AD), but its utility may be limited by conventional quantitative or qualitative evaluation techniques ...
James Zou, David Park, Aubrey Johnson, Xinyang Feng, Michelle Pardo, Jeanelle France, Zeljko Tomljanovic, Adam M. Brickman, Devangere P. Devanand, José A. Luchsinger, William C. Kreisl, Frank A. Provenzano, for the Alzheimer's Disease Neuroimaging Initiative   +12 more
doaj   +1 more source

Why musical memory can be preserved in advanced Alzheimer's disease [PDF]

, 2015
Musical memory is relatively preserved in Alzheimer's disease and other dementias. In a 7 Tesla functional MRI study employing multi-voxel pattern analysis, Jacobsen et al.
Chételat, Gael, Fritz, ThomasLW1780200091355331448AC4-F0EE-11E1-A9DE-61C894A0A6B4, Jacobsen, Jörn-Henrik, Kullmann, Dimitrieditor, Stelzer, Johannes   +4 more
core   +2 more sources

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]

, 2015
Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S., Cameron, Ryan T., Hillert, Ellin-Kristina, MacLeod, Ruth   +3 more
core   +1 more source

EEG UPPER/LOW ALPHA FREQUENCY POWER RATIO RELATES TO TEMPORO-PARIETAL BRAIN ATROPHY AND MEMORY PERFORMANCES IN MILD COGNITIVE IMPAIRMENT

Frontiers in Aging Neuroscience, 2013
Objective: temporo-parietal cortex thinning is associated to mild cognitive impairment (MCI) due to Alzheimer disease (AD). The increase of EEG upper/low alpha power ratio has been associated with AD-converter MCI subjects.
Davide Vito Moretti, donata epaternicò, Giuliano eBinetti, Orazio eZanetti, giovanni b Frisoni   +4 more
doaj   +1 more source

Monoaminergic Neuropathology in Alzheimer's disease [PDF]

, 2016
Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira, Buée, Luc, Delalle, Ivana, Giovanni, Giuseppe Di, Harrington, Charles R., Hof, Patrick R., Jovanov-Milošević, Nataša, Leko, Mirjana Babić, Silva, Rohan de, Wischik, Claude M., Wray, Selina, Šimić, Goran   +11 more
core   +1 more source

Accelerating diversity in Alzheimer's disease research by partnering with a community advisory board

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023
Introduction Community advisory boards (CABs) and researcher partnerships present a promising opportunity to accelerate enrollment of underrepresented groups (URGs).
Alex Pena‐Garcia, Ralph Richards, Mollie Richards, Christopher Campbell, Hank Mosley, Joseph Asper, Johanne Eliacin, Angelina Polsinelli, Liana Apostolova, Hugh Hendrie, Andrew Tackett, Caprice Elliott, Sarah Van Heiden, Sujuan Gao, Andrew Saykin, Sophia Wang, IADRC CAB   +16 more
doaj   +1 more source

What Can Quantitative Gait Analysis Tell Us about Dementia and Its Subtypes? A Structured Review [PDF]

, 2017
Distinguishing dementia subtypes can be difficult due to similarities in clinical presentation. There is increasing interest in discrete gait characteristics as markers to aid diagnostic algorithms in dementia.
Galna, Brook, Mc Ardle, Ríona, Morris, Rosie, Rochester, Lynn, Thomas, Alan J., Wilson, Joanna   +5 more
core   +2 more sources