Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy
Nature CommunicationsNeurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor
Virginia Gao +15 more
doaj +1 more source
Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease [PDF]
, 2019 The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that dietary interventions represent helpful tools for preventing NDs.
Antonella Amato +2 more
core +1 more source
Mitochondrial control of microglial phagocytosis in Alzheimer’s disease [PDF]
, 2021 Lauren H. Fairley +9 more
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu +9 more
wiley +1 more source
On bloodvessel branching analysis for the detection of Alzheimer's disease
, 2014 Alzheimer’s Disease (AD) is increasingly prevalent in modern society and methods for its diagnosis are only just starting to emerge. Given images of brain tissue, we show how Alzheimer’s disease can be detected from the branching structures of blood ...
Carare, Roxana O. +2 more
core
The Notebook: An Accidental Alzheimer\u27s Awareness Campaign [PDF]
, 2014 My paper examines and critiques the portrayal of Alzheimer¹s disease in the popular film, The Notebook. Based off of a Nicholas Sparks novel, The Notebook uses Alzheimer¹s disease as a vehicle to relay a love story, but in doing so, presents a distorted ...
Waldron, Danielle
core +1 more source
Neuroprotective Effects of the Psychoactive Compound Biatractylolide (BD) in Alzheimer’s Disease [PDF]
, 2022 Qianmei Hu +7 more
openalex +1 more source
The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen +5 more
wiley +1 more source
A conformational variant of p53 (U-p53AZ) as blood-based biomarker for the prediction of the onset of symptomatic Alzheimer’s disease [PDF]
, 2021 Simona Piccirella +8 more
openalex +1 more source
Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu +16 more
wiley +1 more source