Results 151 to 160 of about 9,943,375 (345)

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

The conceptual relevance of assessment measures in patients with mild/mild-moderate Alzheimer\u27s disease [PDF]

, 2018
Introduction: This study aims to evaluate the conceptual relevance of four measures of disease activity in patients with mild/mild-moderate Alzheimer\u27s disease (AD): (1) the Alzheimer\u27s Disease Assessment Scale–Cognitive Subscale; (2) the Alzheimer\
Al-Zubeidi, Tamara, Aldhouse, Natalie V.J., Hartry, Ann, Knight, Sarah L., Sanon, Myrlene, Stefanacci, Richard G.   +5 more
core   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Predicting the course of Alzheimer's progression. [PDF]

, 2019
Alzheimer's disease is the most common neurodegenerative disease and is characterized by the accumulation of amyloid-beta peptides leading to the formation of plaques and tau protein tangles in brain.
Aisen, Paul S, Alzheimer’s Disease Neuroimaging Initiative, Donohue, Michael C, Iddi, Samuel, Li, Dan, Rafii, Michael S, Thompson, Wesley K   +6 more
core  

Machine Learning Predictive Models Can Improve Efficacy of Clinical Trials for Alzheimer’s Disease

, 2020
Ali Ezzati, Richard B. Lipton
openalex   +2 more sources

Alzheimer's disease.

Cold Spring Harbor Perspectives in Biology, 2011
D. Selkoe
semanticscholar   +1 more source

Catalytic TiO2 with Self‐Assembled Monolayer for Highly Sensitive, Selective, and Non‐Invasive Monitoring of Sweat L‐Cysteine

Advanced Functional Materials, EarlyView.
A self‐assembled monolayer of 3‐mercaptopropyltrimethoxysilane (MPTS) molecular receptor and titanium oxide‐modified carbon cloth (MPTS/TiO2/CC) was synthesized for the specific detection of sweat L‐cysteine, which is associated with the precision neutrition, cardiovascular system and neuro system.
Xiangjie Chen, Jia Zhu, Jian Shao, Taisong Pan, Guang Yao, Min Gao, Jian Yang, Rui Zhao, Libin Huang, Tao Li, Huanyu Cheng, Yuan Lin   +11 more
wiley   +1 more source

Gene module-trait network analysis uncovers cell type specific systems and genes relevant to Alzheimer's Disease

Acta Neuropathologica Communications
Alzheimer’s Disease (AD) is marked by the accumulation of pathology, neuronal loss, and gliosis and frequently accompanied by decline in cognition.
Katia de Paiva Lopes, Ricardo A. Vialle, Gilad Green, Masashi Fujita, Chris Gaiteri, Vilas Menon, Julie A. Schneider, Yanling Wang, Philip L. De Jager, Naomi Habib, Shinya Tasaki, David A. Bennett   +11 more
doaj   +1 more source

The Degeneration of the Human Mind: An Analysis of Alzheimer’s Disease, A Kuhnian Perspective [PDF]

, 2013
In 1906, a German physician, Dr. Alois Alzheimer, specifically identified a collection of brain cell abnormalities (and the formation of plaque in the brain) as a disease, which forever changed the way scientists view degenerative cognitive disorders ...
Ilg, Genevieve
core   +1 more source