Differential vulnerability of the dentate gyrus to tauopathies in dementias
Acta Neuropathologica Communications, 2023 The dentate gyrus (DG), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the Alzheimer’s type due to Alzheimer’s disease (DAT-AD), but less is known about the susceptibility ...
Allegra Kawles +14 more
doaj +1 more source
Assessment of Screening Approach in Early and Differential Alzheimer’s Disease Diagnosis
Antioxidants, 2021 Background: Alzheimer’s disease (AD) is the leading cause of dementia in the elderly population. Currently, diagnosis is based on invasive and expensive techniques, so there is a growing need to look for other possible tests, as well as carry out ...
Laura Ferré-González +5 more
doaj +1 more source
Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease [PDF]
, 2019 Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Burris, Thomas P +9 more
core +3 more sources
Epidemiology and Genetics of AlzheimerÂ’s Disease
Journal of Alzheimer’s Disease & Parkinsonism, 2015 Alzheimer’s disease (AD) is the most common form of dementia. It is a degenerative and incurable terminal disease. AD accounts for 75% of all forms of dementia all over the world. Its etiology is still unknown. Numerous risk factors of AD have already been discovered. In this paper, some preliminary results are presented.
Sery Omar +7 more
openaire +2 more sources
Alzheimer’s disease frequency peaks in the tenth decade and is lower afterwards
Acta Neuropathologica Communications, 2019 Age is the most robust risk factor for Alzheimer’s dementia, however there is little data on the relation of age to Alzheimer’s disease (AD) and other common neuropathologies that contribute to Alzheimer’s dementia.
Jose M. Farfel +6 more
doaj +1 more source
Nuclear dynamics and stress responses in Alzheimer’s disease
Molecular Neurodegeneration, 2021 In response to extracellular and intracellular stressors, the nucleus and nuclear compartments undergo distinct molecular changes to maintain cell homeostasis.
Artemis Iatrou +2 more
doaj +1 more source
Amyloidopathy in the Eye of Alzheimerâ²s Disease [PDF]
Journal of Addiction Research & Therapy, 2011 Alzheimer’s disease (AD) is a devastating neurodegenerative disease and the primary cause of dementia, with no cure available. The pathogenesis of AD is believed to be primarily driven by the accumulation of Aβ, a 4-kDa peptide generated from the amyloid-β precursor protein (APP) through proteolysis.
openaire +1 more source
A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer's Disease Data. [PDF]
, 2019 There is well-documented evidence of brain network differences between individuals with Alzheimer's disease (AD) and healthy controls (HC). To date, imaging studies investigating brain networks in these populations have typically been cross-sectional ...
Alzheimer’s Disease Neuroimaging Initiative +5 more
core +2 more sources
The Assessment of Behavioural Decline in Adults with Down's Syndrome [PDF]
, 2007 The present study examines two methods of using the Vineland Adaptive Behaviour Scales as a measure of behavioural change in people with Down syndrome who are at risk of developing Alzheimer’s disease.
Harte, Cyan +4 more
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Targeting neuroinflammation in Alzheimer’s disease [PDF]
, 2016 Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer’s disease (AD) accounts for approximately 60%–80% of all dementia cases. Given this evidence, it is clear dementia represents one
Bronzuoli, MARIA ROSANNA +3 more
core +1 more source