Results 21 to 30 of about 9,392,963 (368)
Amyloidopathy in the Eye of Alzheimerâ²s Disease [PDF]
Alzheimer’s disease (AD) is a devastating neurodegenerative disease and the primary cause of dementia, with no cure available. The pathogenesis of AD is believed to be primarily driven by the accumulation of Aβ, a 4-kDa peptide generated from the amyloid-β precursor protein (APP) through proteolysis.
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A REVIEW OF BIOCHEMICAL MARKERS FOR EARLY DIAGNOSIS OF ALZHEIMERâS DISEASE [PDF]
Alzheimer’s disease, the most prevalent type of dementia, affects the life of elderly, to such extent that it impairs the ability to perform routine functions as well. The impairment of normal functions not only affects the patients but the family members as well.
Meha Fatima Aftab, Rizwana S. Waraich
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Background Cerebrospinal fluid (CSF) tau and beta-amyloid levels in chronic traumatic encephalopathy (CTE), a disease which can be clinically indistinguishable from Alzheimer’s disease (AD), are largely unknown.
Katherine W. Turk+20 more
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Aluminum compounds can be easily found in the environment. Aluminum contamination is the environmental factor as one of the risk factors for Alzheimer's disease (AD). In the animal model, aluminum chloride (AlCl3) induces inflammation and oxidative stress. Inflammation and oxidative stress are important pathogenesis pathways in the AD.
Muhammad Ihwan Narwanto+3 more
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Common age‐related neuropathologies and yearly variability in cognition
Objective Cognitive variability is a potentially important source of heterogeneity in longitudinal cognitive profiles. We examined the extent to which common age‐related neuropathologies including Lewy bodies and Alzheimer’s disease (AD) contribute to ...
Lei Yu+6 more
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Age-related neurodegenerative diseases: role of enzyme crucial to membrane function Targeting a critical enzyme involved in the metabolism of cellular membrane molecules could help treat age-related neurodegenerative diseases.
Min Hee Park+2 more
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Quantification of in vivo amyloid and tau PET imaging relationships with postmortem measurements are critical for validating the sensitivity and specificity imaging biomarkers across clinical phenotypes with Alzheimer disease neuropathologic change (ADNC)
Adam Martersteck+9 more
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Background Primary progressive aphasia (PPA) is a clinical dementia syndrome. Impairments in language (speaking, reading, writing, and understanding) are the primary and persistent symptoms.
Angela C. Roberts+8 more
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Background Longitudinal investigations are needed to improve understanding of the contributions of cerebral small vessel disease to the clinical manifestation of Alzheimer’s disease, particularly in the early disease stages.
Christian Puzo+13 more
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Background This study examined neuropathological findings of patients who died following hospitalization in an intensive care unit with SARS-CoV-2. Methods Data originate from 20 decedents who underwent brain autopsy followed by ex-vivo imaging and ...
Sonal Agrawal+12 more
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