Results 21 to 30 of about 9,943,375 (345)

Targeting neuroinflammation in Alzheimer’s disease [PDF]

, 2016
Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer’s disease (AD) accounts for approximately 60%–80% of all dementia cases. Given this evidence, it is clear dementia represents one
Bronzuoli, MARIA ROSANNA, Iacomino, Aniello, Scuderi, Caterina, Steardo, Luca   +3 more
core   +1 more source

Multimodal MRI-based Imputation of the Aβ+ in Early Mild Cognitive Impairment. [PDF]

, 2014
ObjectiveTo identify brain atrophy from structural-MRI and cerebral blood flow(CBF) patterns from arterial spin labeling perfusion-MRI that are best predictors of the Aβ-burden, measured as composite 18F-AV45-PET uptake, in individuals with early mild ...
Joshi, Sarang, the Alzheimer’s Disease Neuroimaging Initiative, Tosun, Duygu, Weiner, Michael W   +3 more
core   +1 more source

A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease

Alzheimer’s Research & Therapy, 2022
Background Cerebrospinal fluid (CSF) tau and beta-amyloid levels in chronic traumatic encephalopathy (CTE), a disease which can be clinically indistinguishable from Alzheimer’s disease (AD), are largely unknown.
Katherine W. Turk, Alexandra Geada, Victor E. Alvarez, Weiming Xia, Jonathan D. Cherry, Raymond Nicks, Gaoyuan Meng, Sarah Daley, Yorghos Tripodis, Bertrand R. Huber, Andrew E. Budson, Brigid Dwyer, Neil W. Kowall, Robert C. Cantu, Lee E. Goldstein, Douglas I. Katz, Robert A. Stern, Michael L. Alosco, Jesse Mez, Ann C. McKee, Thor D. Stein   +20 more
doaj   +1 more source

Understanding Alzheimer’s Disease Knowledge in Low-Income, Richmond, VA Community Dwelling Older Adults [PDF]

, 2020
Background: Different populations of individuals demonstrate varying levels of Alzheimer’s disease (AD) knowledge, as well as commonly held misconceptions about the nature of the disease and its risk factors.
Inker, Jennifer, Rhodes, Ann, Richardson, Joann, Wilkerson, Taylor, Zanjani, Faika   +4 more
core   +1 more source

Inverse association between cancer and Alzheimer’s disease: results from the Framingham Heart Study [PDF]

, 2012
Objectives: To relate cancer since entry into the Framingham Heart Study with the risk of incident Alzheimer’s disease and to estimate the risk of incident cancer among participants with and without Alzheimer’s disease.
Au, Rhoda, Beiser, Alexa, Driver, Jane A, Kiel, Douglas P, Kreger, Bernard E, Kurth, Tobias, Lu, Kun Ping, Seshadri, Sudha, Splansky, Greta Lee, Wolf, Phillip A   +9 more
core   +1 more source

Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology

Acta Neuropathologica Communications, 2022
Quantification of in vivo amyloid and tau PET imaging relationships with postmortem measurements are critical for validating the sensitivity and specificity imaging biomarkers across clinical phenotypes with Alzheimer disease neuropathologic change (ADNC)
Adam Martersteck, Ivan Ayala, Daniel T. Ohm, Callen Spencer, Christina Coventry, Sandra Weintraub, Eileen H. Bigio, M. -Marsel Mesulam, Changiz Geula, Emily Rogalski   +9 more
doaj   +1 more source

Common age‐related neuropathologies and yearly variability in cognition

Annals of Clinical and Translational Neurology, 2019
Objective Cognitive variability is a potentially important source of heterogeneity in longitudinal cognitive profiles. We examined the extent to which common age‐related neuropathologies including Lewy bodies and Alzheimer’s disease (AD) contribute to ...
Lei Yu, Tianhao Wang, Robert S. Wilson, Sue Leurgans, Julie A. Schneider, David A. Bennett, Patricia A. Boyle   +6 more
doaj   +1 more source

Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer’s Coordinating Center Uniform Data Set

Alzheimer’s Research & Therapy, 2019
Background Longitudinal investigations are needed to improve understanding of the contributions of cerebral small vessel disease to the clinical manifestation of Alzheimer’s disease, particularly in the early disease stages.
Christian Puzo, Caroline Labriola, Michael A. Sugarman, Yorghos Tripodis, Brett Martin, Joseph N. Palmisano, Eric G. Steinberg, Thor D. Stein, Neil W. Kowall, Ann C. McKee, Jesse Mez, Ronald J. Killiany, Robert A. Stern, Michael L. Alosco   +13 more
doaj   +1 more source

Communication Bridge™-2 (CB2): an NIH Stage 2 randomized control trial of a speech-language intervention for communication impairments in individuals with mild to moderate primary progressive aphasia

Trials, 2022
Background Primary progressive aphasia (PPA) is a clinical dementia syndrome. Impairments in language (speaking, reading, writing, and understanding) are the primary and persistent symptoms.
Angela C. Roberts, Alfred W. Rademaker, Elizabeth Ann Salley, Aimee Mooney, Darby Morhardt, Melanie Fried-Oken, Sandra Weintraub, Marsel Mesulam, Emily Rogalski   +8 more
doaj   +1 more source

Low-Cost Portable Light Therapy for Alzheimer's Patients [PDF]

, 2019
This paper provides an overview of the information and research conducted that ushered the creation and innovation of a low-cost portable light therapy device to help treat Alzheimer’s patients.
Arasu, Melghi, Zoghi, Ben, Zoghi, Sara
core   +1 more source