Results 71 to 80 of about 9,392,963 (368)
Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden +15 more
wiley +1 more source
Pathogenic PS1 phosphorylation at Ser367
eLife, 2017 The high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its ‘phosphorylated’ and ...
Masato Maesako +10 more
doaj +1 more source
Validation study of “Santé-Cerveau”, a digital tool for early cognitive changes identification
Alzheimer’s Research & Therapy, 2023 Background There is a need for a reliable, easy-to-use, widely available, and validated tool for timely cognitive impairment identification. We created a computerized cognitive screening tool (Santé-Cerveau digital tool (SCD-T)) including validated ...
Constance Lesoil +12 more
doaj +1 more source
Journal of Alzheimer’s Disease & Parkinsonism, 2015 Alzheimer’s disease (AD) and cerebrovascular disease (CVD) frequently co-exist and are part of a syndrome that may result in ageing-related cognitive impairment and dementia. Somemen and women with the neurodegenerative and cerebrovascular changes associated with dementia have normal cognition ascribed to a high cognitive reserve or resilience.
openaire +3 more sources
2020 Alzheimer's disease facts and figures
Alzheimer's & Dementia, 2020 This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society.
semanticscholar +1 more source
CSF Biomarker‐Based Cognitive Trajectories in Parkinson's Disease‐Subjective Cognitive Decline
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cognitive complaints without objective cognitive impairment in Parkinson's Disease, termed Parkinson's Disease‐Subjective Cognitive Decline (PD‐SCD), have been associated with cognitive decline. However, its progression is heterogeneous, highlighting the need for improved identification of patients at greater risk for deterioration ...
Jon Rodriguez‐Antiguedad +7 more
wiley +1 more source
G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults
Communications BiologyAccumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected.
Shahram Oveisgharan +10 more
doaj +1 more source
Reproducibility of serum cytokines in an elderly population
Immunity & Ageing, 2020 Background It is important to assess the temporal reproducibility of circulating cytokines for their utility in epidemiological studies. However, existing evidence is limited and inconsistent, especially for the elderly population.
Jing Guo +3 more
doaj +1 more source
Effects of simvastatin on white matter integrity in healthy middle‐aged adults
Annals of Clinical and Translational Neurology, 2021 Background The brain is the most cholesterol‐rich organ and myelin contains 70% of total brain cholesterol. Statins are potent cholesterol‐lowing medications used by millions of adults for prevention of vascular disease, yet the effect of statins on ...
Nicholas M. Vogt +12 more
doaj +1 more source
, 2016 Additional file 2. The approval Letter from National Institutes of Health.
Shun-Ku Lin +3 more
openaire +1 more source