Results 71 to 80 of about 9,943,375 (345)

Souvenaid in the Management of Mild Cognitive Impairment: An Expert Consensus Opinion [PDF]

, 2019
Background Mild cognitive impairment (MCI) among an aging global population is a growing challenge for healthcare providers and payers. In many cases, MCI is an ominous portent for dementia.
Bertolucci, Paulo, Cappa, Stefano, Chen, Christopher, Chu, Leung-Wing, Cummings, Jeffrey, Engelborghs, Sebastiaan, Garcia-Ribas, Guillermo, Manzano, Sagrario, McGuinness, Bernadette, Mok, Vincent, Passmore, Peter, Woodward, Michael   +11 more
core   +3 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Inverse comorbidity: the power of paradox in the advancement of science [PDF]

, 2013
Research on comorbidity and multimorbidity is finally receiving the attention it deserves, particularly considering the magnitude and impact they have on health and the delivery of healthcare [1,2].
Tabarés-Seisdedos, Rafael, Valderas, Jose M.   +1 more
core   +3 more sources

Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer’s disease [PDF]

, 2022
Martina Gabrielli, Ilaria Prada, Pooja Joshi, Chiara Falcicchia, Giulia D’Arrigo, Grazia Rutigliano, Elisabetta Battocchio, Rossella Zenatelli, Francesca Tozzi, Annalisa Radeghieri, Ottavio Arancio, Nicola Origlia, Claudia Verderio   +12 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease

Experimental and Molecular Medicine
Over the past decade, numerous studies have highlighted the importance of acid sphingomyelinase (ASM) in disease treatment in humans. This enzyme functions primarily to generate ceramide, maintain the cellular membrane, and regulate cellular function ...
Byung Jo Choi, Min Hee Park, Hee Kyung Jin, Jae-sung Bae   +3 more
doaj   +1 more source

Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer’s disease

Translational Neurodegeneration, 2021
Background Neuropsychiatric symptoms (NPS) are increasingly recognized as early non-cognitive manifestations in the Alzheimer’s disease (AD) continuum.
Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Yiong Huak Chan, Lai Jiang, Joseph Therriault, Andrea L. Benedet, Monica Shin, Nagaendran Kandiah, Celia M. T. Greenwood, Pedro Rosa-Neto, Serge Gauthier, Dominantly Inherited Alzheimer Network   +12 more
doaj   +1 more source

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan, Stephanie A. Chu, Suvi Häkkinen, Liwen Zhang, David McFall, Jonathan D. Rohrer, Jesse A. Brown, Alex J. Lee, Kristen Fernhoff, Lorenzo Pasquini, Katherine P. Rankin, Maria Luisa Mandelli, Maria Luisa Gorno‐Tempini, Jennifer S. Yokoyama, Virginia E. Sturm, Brian Appleby, Bradford C. Dickerson, Kimiko Domoto‐Reilly, Tatiana Foroud, Daniel H. Geschwind, Nupur Ghoshal, Neill R. Graff‐Radford, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward Huey, Kejal Kantarci, Irene Litvan, Ian R. Mackenzie, Mario F. Mendez, Chiadi U. Onyike, Leonard Petrucelli, Eliana Marisa Ramos, Erik D. Roberson, Julio C. Rojas, Maria Carmela Tartaglia, Arthur W. Toga, Sandra Weintraub, Leah K. Forsberg, Hilary W. Heuer, Brad F. Boeve, Adam L. Boxer, Howard J. Rosen, Bruce L. Miller, Fermin Moreno, William W. Seeley, Suzee E. Lee, on behalf of the ALLFTD Consortium   +46 more
wiley   +1 more source

Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males

Nature Communications, 2023
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI), but the components of RHI exposure underlying this relationship are unclear.
Daniel H. Daneshvar, Evan S. Nair, Zachary H. Baucom, Abigail Rasch, Bobak Abdolmohammadi, Madeline Uretsky, Nicole Saltiel, Arsal Shah, Johnny Jarnagin, Christine M. Baugh, Brett M. Martin, Joseph N. Palmisano, Jonathan D. Cherry, Victor E. Alvarez, Bertrand R. Huber, Jennifer Weuve, Christopher J. Nowinski, Robert C. Cantu, Ross D. Zafonte, Brigid Dwyer, John F. Crary, Lee E. Goldstein, Neil W. Kowall, Douglas I. Katz, Robert A. Stern, Yorghos Tripodis, Thor D. Stein, Michael D. McClean, Michael L. Alosco, Ann C. McKee, Jesse Mez   +30 more
doaj   +1 more source

Automatic memory processes in normal ageing and Alzheimer’s disease [PDF]

, 2008
This study examined the contribution of automatic and controlled uses of memory to stem completion in young, middle-aged and older adults, and compared these data with a study involving patients with Alzheimer’s disease (AD) who performed the same task ...
Adam, Albert, Bäckman, Bäckman, Carlesimo, Cermak, Chiarello, Clarys, Curran, Davis, DeKosky, Deweer, Fleischman, Folstein, Fuster, Gabrieli, Graf, Habib, Hudson, Hultsch, Huppert, Jacoby, Jacoby, Jacoby, Jennings, Jermann, John M. Hudson, Knight, Koivisto, La Voie, Light, McKhann, Meiran, Mitchell, Morris, Nelson, Neumann, Partridge, Reingold, Richardson-Klavehn, Russo, Ryan, Salthouse, Schacter, Schmitter-Edgecombe, Smith, Squire, Titov, Toth, Zelazo   +49 more
core   +1 more source