Results 181 to 190 of about 25,152,973 (316)

Early, sex-dependent and progressive proteomic imbalance in the amygdala during Alzheimer´s disease continuum. [PDF]

Biol Sex Differ
Romero-Murillo S, Lachén-Montes M, Cartas-Cejudo P, Anaya-Cubero E, de Miguel M, Extramiana L, Ferrer I, Fernández-Irigoyen J, Santamaría E.   +8 more
europepmc   +1 more source

Dementia Caregiving in Indiana: Data from the 2015 Behavioral Risk Factor Surveillance System

In Indiana, more than 60 percent of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers ...

core  

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Effectiveness of Souvenaid® combined with acetylcholinesterase inhibitors on caregiver burden in Alzheimer´s disease. [PDF]

Alzheimers Dement (N Y)
García-Alberca JM, Mendoza S, DE LA Guía P, López DE LA Rica M.   +3 more
europepmc   +1 more source

Dementia caregiving in Arizona: Data from the 2016 Behavioral Risk Factor Surveillance System

In Arizona, more than half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for ...

core  

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Dementia Caregiving in New Jersey: Data from the 2015 Behavioral Risk Factor Surveillance System

In New Jersey, more than half of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for ...

core  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Selective oestrogen receptor modulators and Alzheimer´s disease: a real-world pharmacovigilance study. [PDF]

Eur J Clin Pharmacol
Yuste MT, Badillo E, Galecio JS, Marín P.   +3 more
europepmc   +1 more source

Dementia Caregiving in Iowa: Data from the 2015 Behavioral Risk Factor Surveillance System

In Iowa, more than one-third of all adults providing unpaid care to loved ones with Alzheimer\u2019s or another dementia have been doing so for at least two years.This Fact Sheet is supported by Cooperative Agreement #NU58DP006115 from the Centers for ...

core