Results 31 to 40 of about 25,152,973 (316)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement
Biomolecules, 2019 Alzheimer’s disease, a major and increasing global health challenge, is an irreversible, progressive form of dementia, associated with an ongoing decline of brain functioning.
Gabriela Dumitrita Stanciu +7 more
doaj +1 more source
, 2009 Download: World Alzheimer Report 2009 executive SummaryAlzheimer’s disease and other dementias have been reliably identified in all countries, cultures and races in which systematic research has been carried out.
Alzheimer's Disease International (ADI)
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
, 2015 Additional file 2: Table S2. MRM transitions used for identification.
Anderson, Kyle, Illarion Turko
openaire +1 more source
Targeting brain, body and heart for cognitive health and dementia prevention [PDF]
, 2012 This report looks into the current research regarding dementia and Alzheimer\u27s disease prevention and offers ideas for possible future solutions. Prevention of dementia is the ultimate aim of a large, albeit under resourced, international ...
Elodie O'Connor, Maree Farrow
core
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Diseases, 2018 Alzheimer’s disease is a neurodegenerative sickness, where the speed of personal disease progression differs prominently due to genetic and environmental factors such as life style.
Satoru Matsuda +5 more
doaj +1 more source
IEEE Access, 2022 Machine learning algorithms have been used for detection (and possibly) prediction of Alzheimer’s disease using genotype information, with the potential to enhance the outcome prediction.
Abbas Saad Alatrany +3 more
doaj +1 more source