Results 41 to 50 of about 25,152,973 (316)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Explainable Machine Learning Model for Alzheimer Detection Using Genetic Data: A Genome-Wide Association Study Approach

IEEE Access
Recent research has revealed that using machine learning systems for the analysis of genetic data could reliably detect Alzheimer’s disease. The interpretability of these models, however, has been a challenge, as they frequently provided little ...
Tarek Khater, Sam Ansari, Abbas Saad Alatrany, Haya Alaskar, Soliman Mahmoud, Ayad Turky, Hissam Tawfik, Eqab Almajali, Abir Hussain   +8 more
doaj   +1 more source

Additional file 3: of Older patients are still under-represented in clinical trials of Alzheimerâ s disease

, 2016
List of studies included. (DOCX 34 kb)
Banzi, Rita, Camaioni, Paolo, Tettamanti, Mauro, Bertele’, Vittorio, Lucca, Ugo   +4 more
openaire   +1 more source

2011 Alzheimer's Disease Facts and Figures

, 2011
2011 Alzheimer’s Disease Facts and Figures provides a statistical resource for U.S. data related to Alzheimer’s disease, the most common type of dementia, as well as other dementias.
Alzheimer's Association USA
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Additional file 2: of Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimerâ s disease

, 2016
Is an acknowledgements list for ADNI publications: ADNI infrastructure and site investigators. (PDF 661 kb)
Alexopoulos, Panagiotis, Werle, Lukas, Roesler, Jennifer, Thierjung, Nathalie, Gleixner, Lena, Yakushev, Igor, Laskaris, Nikolaos, Wagenpfeil, Stefan, Gourzis, Philippos, Kurz, Alexander, Perneczky, Robert   +10 more
openaire   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Additional file 1 of A novel approach for multi-SNP GWAS and its application in Alzheimerâ s disease

, 2016
Table 3. Gene pairs with SNP pairs having r 2â Ľ 0.04. (PDF 169 kb)
Bodily, Paul, M. Fujimoto, Page, Justin, Clement, Mark, Ebbert, Mark, Ridge, Perry   +5 more
openaire   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Amyloid precursor protein in peripheral granulocytes as a potential biomarker for Alzheimer’s disease

Bangladesh Journal of Pharmacology, 2016
The aim of this study was to assess the potential of amyloid precursor protein in peripheral granulocytes as a diagnostic biomarker for early detection of Alzheimer’s disease.
Xiaonan Wang, Xihai Li, Jie Yang, Ming Yu, Jinmei Wu   +4 more
doaj