Results 21 to 30 of about 158,526 (239)

Exploring sex differences in Alzheimer’s disease: a comprehensive analysis of a large patient cohort from a memory unit

Alzheimer’s Research & Therapy
Background Alzheimer’s disease (AD) stands as the leading cause of dementia worldwide, and projections estimate over 150 million patients by 2050. AD prevalence is notably higher in women, nearly twice that of men, with discernible sex differences in ...
Maitee Rosende-Roca, Fernando García-Gutiérrez, Yahveth Cantero-Fortiz, Montserrat Alegret, Vanesa Pytel, Pilar Cañabate, Antonio González-Pérez, Itziar de Rojas, Liliana Vargas, Juan Pablo Tartari, Ana Espinosa, Gemma Ortega, Alba Pérez-Cordón, Mariola Moreno, Sílvia Preckler, Susanna Seguer, Miren Jone Gurruchaga, Lluís Tárraga, Agustín Ruiz, Sergi Valero, Mercè Boada, Marta Marquié   +21 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Interest in genetic susceptibility testing and disclosure of AD dementia risk in cognitively normal adults: a survey study

Alzheimer’s Research & Therapy
Background Apolipoprotein-E (APOE) genetic testing for Alzheimer’s disease is becoming more important as clinical trials are increasingly targeting individuals carrying APOE-ε4 alleles. Little is known about the interest in finding out one’s genetic risk
Lisa Waterink, Larissa A. Masselink, Sven J. van der Lee, Leonie N. C. Visser, Solange Cleutjens, Jetske van der Schaar, Argonde C. van Harten, Philip Scheltens, Sietske A. M. Sikkes, Wiesje M. van der Flier, Marissa D. Zwan   +10 more
doaj   +1 more source

Model analogies between pattern formation in deforming engineering materials & morphogenesis in ageing human brains

Journal of the Mechanical Behavior of Materials, 2019
Mathematical models developed within the material mechanics and material physics communities have been routinely adapted to interpret and further understand physiological and biological processes.
Tsolakis Apostolos C., Petsos George, Kapetanou Olga, Nikolaidis Ioannis N., Aifantis Elias C.   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Unveiling the sound of the cognitive status: Machine Learning-based speech analysis in the Alzheimer’s disease spectrum

Alzheimer’s Research & Therapy
Background Advancement in screening tools accessible to the general population for the early detection of Alzheimer’s disease (AD) and prediction of its progression is essential for achieving timely therapeutic interventions and conducting decentralized ...
Fernando García-Gutiérrez, Montserrat Alegret, Marta Marquié, Nathalia Muñoz, Gemma Ortega, Amanda Cano, Itziar De Rojas, Pablo García-González, Clàudia Olivé, Raquel Puerta, Ainhoa García-Sanchez, María Capdevila-Bayo, Laura Montrreal, Vanesa Pytel, Maitee Rosende-Roca, Carla Zaldua, Peru Gabirondo, Lluís Tárraga, Agustín Ruiz, Mercè Boada, Sergi Valero   +20 more
doaj   +1 more source

Carolyn Halpin-Healy on her experience as Co-Founder and Executive Director of Arts & Minds in conversation with Sara Torres

Arte, Individuo y Sociedad, 2017
Arts&Minds is a non-for-prfit organization and its goal is to improve well-being for people living with dementia and their cargivers through meaningful contact with art.
Sara Torres, Carolyn Halpin-Healy
doaj   +1 more source

Effectiveness of a Family Support Intervention on Caregiving Burden in Family of Elderly Patients With Cognitive Decline After the COVID-19 Lockdown

Frontiers in Psychiatry, 2021
Background: The coronavirus disease 2019 (COVID-19) pandemic had a great impact on patients with cognitive decline or dementia. The lockdown period may exacerbate behavioral disorders and worsen distress of caregivers.
Luca Cravello, Eleonora Martini, Niccolò Viti, Cristina Campanello, Francesca Assogna, Daniele Perotta   +5 more
doaj   +1 more source