Results 11 to 20 of about 162,861 (120)

Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

eLife, 2020
To study the mechanisms by which the p.R47H variant of the microglia gene and Alzheimer’s disease (AD) risk factor TREM2 increases dementia risk, we created Trem2R47H KI rats.
Siqiang Ren, Wen Yao, Marc D Tambini, Tao Yin, Kelly A Norris, Luciano D'Adamio   +5 more
doaj   +1 more source

Pathways to participation – a scoping review outlining barriers and enablers to participation in dementia research

The Journal of Prevention of Alzheimer's Disease
Background: Ongoing participant recruitment challenges in dementia research highlight the need to understand public perspectives on research participation.
Lukas A. Duffner, Soraya Moradi-Bachiller, Dianne Gove, Ana M. Diaz-Ponce, Angela Bradshaw, Jean Georges   +5 more
doaj   +1 more source

NECESIDADES DEL CUIDADOR DEL ENFERMO DE ALZHEIMER TERMINAL.

Enfermería Global, 2005
La enfermedad de Alzheimer es la primera causa de demencia en la población occidental. Su carácter invalidante delega asistencia permanente desde los estadios moderados de la enfermedad por lo que la dependencia de cuidados constituye su principal ...
S. Sánchez Cánovas, R. Mears Baño
doaj   +1 more source

The Role of Ca²⁺ Signaling in Aging and Neurodegeneration: Insights from Caenorhabditis elegans Models

Cells, 2020
Ca2+ is a ubiquitous second messenger that plays an essential role in physiological processes such as muscle contraction, neuronal secretion, and cell proliferation or differentiation.
Javier Alvarez, Pilar Alvarez-Illera, Paloma García-Casas, Rosalba I. Fonteriz, Mayte Montero   +4 more
doaj   +1 more source

Una escala para medir la aflicción del cuidador del paciente con Alzheimer

Voces desde el Trabajo Social, 2018
El objetivo de este estudio fue introducir el concepto de aflicción del cuidador o cuidadora del paciente con la enfermedad de Alzheimer y validar al español una escala breve para medir sus niveles y así evaluar la efectividad de la intervención ...
Jaime Alvelo Burgos, Rafael Cancio González   +1 more
doaj   +1 more source

Exploring sex differences in Alzheimer’s disease: a comprehensive analysis of a large patient cohort from a memory unit

Alzheimer’s Research & Therapy
Background Alzheimer’s disease (AD) stands as the leading cause of dementia worldwide, and projections estimate over 150 million patients by 2050. AD prevalence is notably higher in women, nearly twice that of men, with discernible sex differences in ...
Maitee Rosende-Roca, Fernando García-Gutiérrez, Yahveth Cantero-Fortiz, Montserrat Alegret, Vanesa Pytel, Pilar Cañabate, Antonio González-Pérez, Itziar de Rojas, Liliana Vargas, Juan Pablo Tartari, Ana Espinosa, Gemma Ortega, Alba Pérez-Cordón, Mariola Moreno, Sílvia Preckler, Susanna Seguer, Miren Jone Gurruchaga, Lluís Tárraga, Agustín Ruiz, Sergi Valero, Mercè Boada, Marta Marquié   +21 more
doaj   +1 more source

Model analogies between pattern formation in deforming engineering materials & morphogenesis in ageing human brains

Journal of the Mechanical Behavior of Materials, 2019
Mathematical models developed within the material mechanics and material physics communities have been routinely adapted to interpret and further understand physiological and biological processes.
Tsolakis Apostolos C., Petsos George, Kapetanou Olga, Nikolaidis Ioannis N., Aifantis Elias C.   +4 more
doaj   +1 more source

Interest in genetic susceptibility testing and disclosure of AD dementia risk in cognitively normal adults: a survey study

Alzheimer’s Research & Therapy
Background Apolipoprotein-E (APOE) genetic testing for Alzheimer’s disease is becoming more important as clinical trials are increasingly targeting individuals carrying APOE-ε4 alleles. Little is known about the interest in finding out one’s genetic risk
Lisa Waterink, Larissa A. Masselink, Sven J. van der Lee, Leonie N. C. Visser, Solange Cleutjens, Jetske van der Schaar, Argonde C. van Harten, Philip Scheltens, Sietske A. M. Sikkes, Wiesje M. van der Flier, Marissa D. Zwan   +10 more
doaj   +1 more source

Carolyn Halpin-Healy on her experience as Co-Founder and Executive Director of Arts & Minds in conversation with Sara Torres

Arte, Individuo y Sociedad, 2017
Arts&Minds is a non-for-prfit organization and its goal is to improve well-being for people living with dementia and their cargivers through meaningful contact with art.
Sara Torres, Carolyn Halpin-Healy
doaj   +1 more source

Unveiling the sound of the cognitive status: Machine Learning-based speech analysis in the Alzheimer’s disease spectrum

Alzheimer’s Research & Therapy
Background Advancement in screening tools accessible to the general population for the early detection of Alzheimer’s disease (AD) and prediction of its progression is essential for achieving timely therapeutic interventions and conducting decentralized ...
Fernando García-Gutiérrez, Montserrat Alegret, Marta Marquié, Nathalia Muñoz, Gemma Ortega, Amanda Cano, Itziar De Rojas, Pablo García-González, Clàudia Olivé, Raquel Puerta, Ainhoa García-Sanchez, María Capdevila-Bayo, Laura Montrreal, Vanesa Pytel, Maitee Rosende-Roca, Carla Zaldua, Peru Gabirondo, Lluís Tárraga, Agustín Ruiz, Mercè Boada, Sergi Valero   +20 more
doaj   +1 more source