Results 131 to 140 of about 9,294,018 (384)

Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia [PDF]

, 2004
BACKGROUND: Consumers of light-to-moderate amounts of alcohol have a lower risk of dementia and, possibly, Alzheimer disease than do abstainers. Because vascular disease may contribute to symptoms of Alzheimer disease, reduction of cerebrovascular ...
Breteler, M.M.B. (Monique), Dijk, E.J. (Ewoud) van, Duijn, C.M. (Cornelia) van, Heijer, T. (Tom) den, Hofman, A. (Albert), Koudstaal, P.J. (Peter), Prins, N.D. (Niels), Vermeer, S.E. (Sarah)   +7 more
core   +1 more source

Home‐Based Tele‐tDCS in Amyotrophic Lateral Sclerosis: Feasibility, Safety, and Preliminary Efficacy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with limited treatment options. Transcranial direct current stimulation (tDCS) shows promise as a neuromodulatory intervention in various neurological disorders, but its application in ALS, particularly in a remote, home‐based format, remains underexplored.
Sangeetha Madhavan, Shravni Deshmukh, Mark Cummings, Aditi Doshi, Kourosh Rezania, Sally Freels, Gina Sawa   +6 more
wiley   +1 more source

Computer‐assisted prediction of clinical progression in the earliest stages of AD

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Individuals with subjective cognitive decline (SCD) are at increased risk for clinical progression. We studied how combining different diagnostic tests can help to identify individuals who are likely to show clinical progression.
Hanneke F.M. Rhodius‐Meester, Hilkka Liedes, Juha Koikkalainen, Steffen Wolfsgruber, Nina Coll‐Padros, Johannes Kornhuber, Oliver Peters, Frank Jessen, Luca Kleineidam, José Luis Molinuevo, Lorena Rami, Charlotte E. Teunissen, Frederik Barkhof, Sietske A.M. Sikkes, Linda M.P. Wesselman, Rosalinde E.R. Slot, Sander C.J. Verfaillie, Philip Scheltens, Betty M. Tijms, Jyrki Lötjönen, Wiesje M. van derFlier   +20 more
doaj   +1 more source

Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

Molecular Neurodegeneration, 2018
Background Despite diverging levels of amyloid-β (Aβ) and TAU pathology, different mouse models, as well as sporadic AD patients show predictable patterns of episodic memory loss.
Annerieke Sierksma, Ashley Lu, Evgenia Salta, Elke Vanden Eynden, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, David Blum, Luc Buée, Mark Fiers, Bart De Strooper   +9 more
doaj   +1 more source

CSF Tau Is a Biomarker of Hippocampal Injury in Cryptogenic New‐Onset Refractory Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cryptogenic new‐onset refractory status epilepticus (cNORSE) is a devastating condition characterized by the de novo onset of status epilepticus with unclear etiology. The identification of relevant early biomarkers in cNORSE is important to elucidate pathophysiology, aid clinical decision‐making, and prognosticate outcomes in cNORSE.
Yihui Goh, Yoonhyuk Jang, Soo Jean Shin, Soo Hyun Ahn, Su Yee Mon, Yoon Hee Shin, Kon Chu, Sang Kun Lee, Soon‐Tae Lee   +8 more
wiley   +1 more source

Threshold Values of Sleep Spindles Features in Healthy Adults Using Scalp‐EEG and Associations With Sleep Parameters

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sleep spindles are an electrophysiological fingerprint of the sleeping human brain. They can be described in terms of duration, frequency, amplitude, and density, and vary widely according to age and sex. Spindles play a role in sleep and wake functions and are altered in several neurological and psychiatric disorders.
Julien Coelho, Heloïse Degros, Jean‐Arthur Micoulaud‐Franchi, Patricia Sagaspe, Emmanuel d'Incau, Paul Galvez, Christian Berthomier, Pierre Philip, Jacques Taillard   +8 more
wiley   +1 more source

Identification of exon skipping events associated with Alzheimer’s disease in the human hippocampus

BMC Medical Genomics, 2019
Background At least 90% of human genes are alternatively spliced. Alternative splicing has an important function regulating gene expression and miss-splicing can contribute to risk for human diseases, including Alzheimer’s disease (AD).
Seonggyun Han, Jason E. Miller, Seyoun Byun, Dokyoon Kim, Shannon L. Risacher, Andrew J. Saykin, Younghee Lee, Kwangsik Nho, for Alzheimer’s Disease Neuroimaging Initiative   +8 more
doaj   +1 more source

Soft-Weighted CrossEntropy Loss for Continous Alzheimer's Disease Detection [PDF]

arXiv
Alzheimer's disease is a common cognitive disorder in the elderly. Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. At present, researchers have used machine learning methods to detect Alzheimer's disease from the speech of participants.
arxiv  

Method, Composition, and Kit Useful for Treatment of Alzheimer\u27s Disease [PDF]

, 2015
The presently-disclosed subject matter includes methods for treating Alzheimer\u27s disease in a subject. The subject can have Alzheimer\u27s diseases, can be identified has being at risk for developing Alzheimer\u27s disease, or both.
Estus, Steven, Malik, Manasi, Simpson, James   +2 more
core   +1 more source

Laminar-specific distribution and infrastructural detail of amyloid in the Alzheimer disease cortex visualized by computer-enhanced imaging of epitopes recognized by monoclonal antibodies. [PDF]

, 1988
Ronald E. Majocha, Francine M. Beneš, Jennifer Reifel, Anne Rodenrys, Charles A. Marotta   +4 more
openalex   +1 more source