A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, finding that NfL demonstrates high prognostic value and distinct ...
Natalia E. Owen +8 more
wiley +1 more source
CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu +12 more
wiley +1 more source
Deep Learning in Early Alzheimer's disease's Detection: A Comprehensive Survey of Classification, Segmentation, and Feature Extraction Methods [PDF]
arXivAlzheimers disease is a deadly neurological condition, impairing important memory and brain functions. Alzheimers disease promotes brain shrinkage, ultimately leading to dementia. Dementia diagnosis typically takes 2.8 to 4.4 years after the first clinical indication.
arxiv
Evidence for early identification of Alzheimer's disease [PDF]
arXiv, 2012 Alzheimer's disease is a human brain disease that affects a significant fraction of the population by causing problems with short-term memory, thinking, spatial orientation and behavior, memory loss and other intellectual abilities. Up to date there is no singular test that can definitively diagnose Alzheimer's disease, although imaging technology ...
arxiv
PROMOTER OF ALZHEIMER??S DISEASE AMYLOID A4 PRECURSOR GENE [PDF]
, 1988 J. Michael Salbaum +2 more
openalex +1 more source
Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden +15 more
wiley +1 more source
3D CNN-based classification using sMRI and MD-DTI images for Alzheimer disease studies [PDF]
arXiv, 2018 Computer-aided early diagnosis of Alzheimers Disease (AD) and its prodromal form, Mild Cognitive Impairment (MCI), has been the subject of extensive research in recent years. Some recent studies have shown promising results in the AD and MCI determination using structural and functional Magnetic Resonance Imaging (sMRI, fMRI), Positron Emission ...
arxiv
Using Qualitative Research to Identify and Address the Unique Needs of Caregivers of Persons with Alzheimer\u27s Disease [PDF]
, 2010 This paper reviews articles describing qualitative research that explores the unique needs of caregivers of patients with Alzheimer\u27s disease. Qualitative research methodologies used in these studies include hermeneutic phenomenology, descriptive ...
Wheeler, Breanda K.
core +1 more source
X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation [PDF]
, 1986 openalex +1 more source
The Case of a 67‐Year‐Old Man With Memory Difficulties and Altered Sleep
Annals of Clinical and Translational Neurology, EarlyView.
Wesley Peng, Borna Bonakdarpour
wiley +1 more source