Results 191 to 200 of about 317,693 (354)

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

Processing of Alzheimer Aβ-Amyloid Precursor Protein: Cell Biology, Regulation, and Role in Alzheimer Disease

, 1994
Sam Gandy, Paul Greengard
openalex   +1 more source

Alzheimer disease: Therapeutic strategies [PDF]

, 1995

openalex   +1 more source

Alzheimer's Disease [PDF]

Annual Review of Public Health, 1989
B T, Hyman, H, Damasio, A R, Damasio, G W, Van Hoesen   +3 more
openaire   +2 more sources

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Lecanemab for mild Alzheimer disease - is there a way forward? [PDF]

Drugs Context
Tampi RR.
europepmc   +1 more source

Quantitative 18F-AV1451 brain tau PET imaging in cognitively normal older adults, mild cognitive impairment, and Alzheimer\u27s disease patients [PDF]

, 2019
Alzheimer\u27s Disease Neuroimaging Initiative,, Ha, Lingxia, Liu, Min, Zhao, Qian, Zhou, Yun   +4 more
core   +1 more source

Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer\u27s disease [PDF]

, 2018
Aschenbrenner, Andrew J, Bateman, Randall J, Benzinger, Tammie L.S., Fagan, Anne M, Gordon, Brian A, Hassenstab, Jason, Li, Yan, McDade, Eric M, Morris, John C, the Dominantly Inherited Alzheimer Network (DIAN),, Wang, Guoqiao, Xiong, Chengjie   +11 more
core   +2 more sources

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals [PDF]

, 1997
Mark A. Smith, Peggy L.R. Harris, Lawrence M. Sayre, George Perry   +3 more
openalex   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source