Results 201 to 210 of about 9,294,018 (384)
On the Relentless Pursuit of an Oral Insulin Delivery System: How Far is Too Far?
Advanced Therapeutics, EarlyView.Injectable insulin preparations have far outpaced oral ones by virtue of adequate bioavailability and are driven by innovations, including insulin pumps, real‐time blood glucose monitoring, and artificial intelligence. In contrast, oral insulin delivery systems, including nanomedicines, continue to struggle and lag due to varied reasons.
Sourav Bhattacharjee
wiley +1 more source
Bio‐inspired functional coacervates
Aggregate, Volume 3, Issue 6, December 2022., 2022 Bio‐inspired functional coacervates have diverse functions. Natural and synthetic coacervates are a new class of materials that have great potential for various biomedical applications, including medical adhesives, drug delivery, and tissue engineering.
Shujun Chen, Qi Guo, Jing Yu
wiley +1 more source
Insulin and Alzheimer disease: type 3 diabetes?
Revista de la Facultad de Medicina, 2007 Alzheimer Disease is a neurodegenerative disease of central nervous system whose incidence will increase in next years. Recent investigations relate alzheimer with insulin signaling defects in neurons. Is alzheimer Disease a type 3 diabetes?
Andrés Jagua Gualdrón +1 more
doaj
The second international conference on alzheimers disease and related disorders
, 1989 openalex +1 more source
Cognitive and neurobiologic markers of early Alzheimer disease [PDF]
, 1996 Marilyn S. Albert
openalex +1 more source
Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice
Advanced Science, EarlyView.This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.
Xianyun Wang +16 more
wiley +1 more source
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals [PDF]
, 1997 Mark A. Smith +3 more
openalex +1 more source
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
Advanced Science, EarlyView.Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei +15 more
wiley +1 more source