Results 231 to 240 of about 9,708,599 (370)

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Longitudinal Associations of Multimodal Core 1 Alzheimer Disease Biomarkers With Cognition in Aging and Preclinical Alzheimer Disease. [PDF]

Neurology
López-Martos D, Suárez-Calvet M, Milà-Alomà M, Gispert JD, Salvadó G, Brugulat-Serrat A, Shekari M, Minguillon C, Zetterberg H, Blennow K, Grau-Rivera O, Sánchez-Benavides G, ALFA study.   +12 more
europepmc   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Age-dependent white matter inflammation and cognitive impairment in the TgAPP21 rat model of Alzheimer disease [PDF]

, 2018
M Brodsky, S Anderson, C Murchison, T Chen, Z Mirzadeh, F Ponce, T Aziz, M Hariz, T Chen, Z Mirzadeh, K Chapple, M Brodsky, S Anderson, C Murchison, C Carroll, R Scott, L Davies, T Aziz, A Fytagoridis, M strm, J Samuelsson, P Blomstedt, M Brodsky, S Anderson, C Murchison, E Mulroy, N Robertson, L Macdonald, A Bok, M Simpson, T Wachter, A Minguez-Castellanos, F Valldeoriola, J Herzog, H Stoevelaar, Z Mirzadeh, K Chapple, M Lambert, A Trster, A Levit, B Allman, R Nagalingam, V Hachinski, S Whitehead   +43 more
openalex   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Cognitive and behavioural predictors of survival in Alzheimer disease:results from a sample of treated patients in a tertiary-referral memory clinic [PDF]

, 2012
Agüero-Torres, Andersen, Brandt, Brookmeyer, Buchner, Cox, Cummings, Doody, Ferri, Folstein, Gambassi, General Register Office for Scotland, Helmer, Hicks, Hötte, Inouye, ISD Scotland, Kaplan, Knopman, Landi, Larson, Lawton, Lezak, Luchsinger, Martyn, McGurn, McKhann, Mental Welfare Commission for Scotland, Mielke, Miller, Morgan, Musicco, Nelson, Newcomer, Rait, Reisberg, Richards, Robbins, Scarmeas, Scarmeas, Schneider, Sinforiani, Solfrizzi, SPSS Inc, Starr, Starr, Starr, Starr, Stern, Stern, Stern, Stern, Thomas, Tsai, Tun, Van Dijk, Wang, Whalley, Whitmer, Wolfson   +59 more
core   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Social Media Discourse Related to Caregiving for Older Adults Living With Alzheimer Disease and Related Dementias: Computational and Qualitative Study [PDF]

Andrew C. Pickett, Danny Valdez, Kelsey L. Sinclair, Wesley J Kochell, Boone Fowler, Nicole E. Werner   +5 more
openalex   +1 more source

Meditation treatment of Alzheimer disease and mild cognitive impairment

, 2020
Yunhui Chen, Jiayuan Zhang, Tiane Zhang, Liu Cao, Yanyan You, Chunjiang Zhang, Xinglong Liu, Qi Zhang   +7 more
openalex   +1 more source