Results 231 to 240 of about 317,693 (354)

Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α‐Synuclein Endocytosis in Parkinson's Disease

Advanced Science, EarlyView.
24p3R is an astrocytic receptor for α‐Syn uptake. When LCN2 is secreted from astrocytes, it binds to its receptor 24p3R in astrocytes and this binding impedes the α‐Syn PFF binding to 24p3R. This in turn inhibits 24p3R‐mediated α‐Syn PFF uptake and reduces the clearance of extracellular α‐Syn by astrocytes, which contributes to α‐Syn spread and ...
Ying‐Ying Jiao, Tian Tian, Zhu Zhu, Lei Cao, Yang Liu, Rui‐An Wang, Zhi‐Yong Zhou, Cong Wang, Ke‐Zhong Zhang, Xiao Lu, Wen‐Wei Yun, Ying‐Mei Lu, Gang Hu, Ren‐Hong Du, Ming Lu   +14 more
wiley   +1 more source

Survival Differences Between Individuals With Typical and Atypical Phenotypes of Alzheimer Disease. [PDF]

Neurology
Bader I, Groot C, Van Der Flier WM, Pijnenburg YAL, Ossenkoppele R.   +4 more
europepmc   +1 more source

Microarray analysis of gene expression in a transgenic Caenorhabditis elegans Alzheimer disease model [PDF]

, 1999
Chris D. Link, Amy Fluet, Carolyn J. Johnson, Carrie Van Doren, Stuart Kim   +4 more
openalex   +1 more source

Gompertz Law‐Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Ageing to Capture Morbidity and Mortality Risks

Advanced Science, EarlyView.
The Gompertz law‐based biological age metric (GOLD BioAge) introduces interpretable convenient and interpretable calculations to capture mortality, disease, and frailty risks. Its applications to proteomics and metabolomics (ProtAge and MetAge) demonstrate clinical potential to enhance aging evaluation and prevent age‐related diseases.
Meng Hao, Hui Zhang, Jingyi Wu, Yaqi Huang, Xiangnan Li, Meijia Wang, Shuming Wang, Jiaofeng Wang, Jie Chen, Zhi jun Bao, Li Jin, Xiaofeng Wang, Zixin Hu, Shuai Jiang, Yi Li   +14 more
wiley   +1 more source

Evaluation of the Revised Criteria for Biological and Clinical Staging of Alzheimer Disease.

JAMA Neurol
Pichet Binette A, Smith R, Salvadó G, Tideman P, Glans I, van Westen D, Groot C, Ossenkoppele R, Stomrud E, Parchi P, Zetterberg H, Blennow K, Mattsson-Carlgren N, Janelidze S, Palmqvist S, Hansson O, Alzheimer’s Disease Neuroimaging Initiative.   +16 more
europepmc   +1 more source

Identification of rare variants in Alzheimer\u27s disease [PDF]

, 2014
Cruchaga, Carlos, Lord, Jenny, Lu, Alexander J   +2 more
core   +1 more source

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

, 1997
Kelly Johnson‐Wood, M. Lee, Ruth Motter, Kang Hu, Grace Gordon, Robin Barbour, Karen Khan, Marcia N. Gordon, Hua Tan, Dora Games, Ivan Lieberburg, Dale Schenk, Peter Seubert, Lisa McConlogue   +13 more
openalex   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source

White Matter Abnormalities and Cognition in Aging and Alzheimer Disease.

JAMA Neurol
Peter C, Sathe A, Shashikumar N, Pechman KR, Workmeister AW, Jackson TB, Huo Y, Mukherjee S, Mez J, Dumitrescu LC, Gifford KA, Bolton CJ, Gaynor LS, Risacher SL, Beason-Held LL, An Y, Arfanakis K, Erus G, Davatzikos C, Tosun-Turgut D, Habes M, Wang D, Toga AW, Thompson PM, Zhang P, Schilling KG, Albert M, Kukull W, Biber SA, Landman BA, Bendlin BB, Johnson SC, Schneider J, Barnes LL, Bennett DA, Jefferson AL, Resnick SM, Saykin AJ, Crane PK, Cuccaro ML, Hohman TJ, Archer DB, Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) Analyst Team, Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Biomarkers of Cognitive Decline Among Normal Adults (BIOCARD) Study Team, and the Alzheimer’s Disease Sequencing Project (ADSP), Zaras D, Yang Y, Durant A, Kanakaraj P, Kim ME, Gao C, Newlin NR, Ramadass K, Khairi NM, Li Z, Yao T, Choi SE, Klinedinst B, Lee ML, Scollard P, Trittschuh EH, Sanders EA.   +62 more
europepmc   +1 more source

Autophagy in alzheimer disease pathogenesis and its therapeutic values. [PDF]

Autophagy Rep
Angst G, Jia N, Esqueda LET, Fan Y, Cai Q, Wang C.   +5 more
europepmc   +1 more source