Results 251 to 260 of about 9,708,599 (370)

Human iPSC-derived APOE4/4 Alzheimer´s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support

Laura Cáceres-Palomo, Elisabeth Sanchez-Mejias, Laura Trujillo-Estrada, Juan José Pérez-Moreno, Elba Lopez-Oliva, Tau En Lim, Leah DeFlitch, Fan Feng, Weizhou Qian, M. Ryan Corces, Mathew Blurton-Jones, Inés Moreno‐González, Alberto Pascual, Javier Vitorica, Juan Antonio Garcia-Leon, Antonia Gutiérrez   +15 more
openalex   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology [PDF]

, 2018
Ances, Beau M, Benzinger, Tammie L.S, Blazey, Tyler M, Christensen, John, Dincer, Aylin, Gordon, Brian A, Hornbeck, Russ C, Jackson, Kelley, McCullough, Austin, Mishra, Shruti, Morris, John C, Su, Yi   +11 more
core   +2 more sources

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Proceedings of the National Academy of Sciences of the United States of America, 1993
W. Strittmatter, A. Saunders, D. Schmechel, M. Pericak-Vance, J. Enghild, G. Salvesen, A. Roses   +6 more
semanticscholar   +1 more source

Olfactory‐to‐Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency‐Specific Oscillatory Decoupling

Advanced Science, EarlyView.
Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang, Zhishen Cai, Xingfeng Mao, Yixuan Zhang, Yunlong Pan, Jiawen Cheng, Xuechun Wang, Hengyi Song, Sasaki Takuya, Ming Lu, Gang Hu, Xiuxiu Liu, Yingmei Lu, Feng Han   +13 more
wiley   +1 more source

Single-cell transcriptomic analysis of Alzheimer’s disease

Nature, 2019
Hansruedi Mathys, J. Dávila-Velderrain, Zhuyu Peng, Fan Gao, S. Mohammadi, Jennie Z. Young, M. Menon, Liang He, Fatema Abdurrob, Xueqiao Jiang, Anthony J. Martorell, R. Ransohoff, B. Hafler, D. Bennett, Manolis Kellis, L. Tsai   +15 more
semanticscholar   +1 more source

Rigid Hollow Microparticles for Enhanced Focused Ultrasound Treatment Under Optoacoustic Guidance

Advanced Science, EarlyView.
By combining focused ultrasound (FUS) and acoustically active hollow borosilicate microparticles (HBMPs), we demonstrate tunable control over interparticle dynamics and their localized thermal energy deposition. Modulation of acoustic frequency and particle concentration tailors the energy delivery, allowing adaptive, material‐based regulation of ...
Nima Mahkam, Yi Chen, Héctor Estrada, Ananya Amitabh, Amirreza Aghakhani, Metin Sitti, Daniel Razansky   +6 more
wiley   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

The Alzheimer\u27s Disease Sequencing Project: Study design and sample selection [PDF]

, 2017
et al,, Koboldt, D. C, Larson, D. E
core   +1 more source

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Nature Reviews Neurology, 2019
Yu Yamazaki, Na Zhao, T. Caulfield, Chia-Chen Liu, G. Bu   +4 more
semanticscholar   +1 more source