Results 251 to 260 of about 317,693 (354)

Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).

, 1995
Bradley T. Hyman, Howard West, G. William Rebeck, Sergey V. Buldyrev, Rosario N. Mantegna, M Ukleja, Shlomo Havlin, H. Eugene Stanley   +7 more
openalex   +1 more source

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Advanced Science, EarlyView.
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin   +6 more
wiley   +1 more source

Presenilins and Alzheimer disease

, 1995
Christine Van Broeckhoven
openalex   +1 more source

H2O2‐Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5‐HT Interactions with Neighboring Proteins Under Oxidative Stress

Advanced Science, EarlyView.
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu, Jiwen Yuan, Tuanjie Zhang, Xinyi Cai, Meng Xu, Xueao Wang, Rui Wang, Bing Zhang, Hai‐Liang Zhu, Yong Qian   +9 more
wiley   +1 more source

Cerebral Amyloid Angiopathy and Downstream Alzheimer Disease Plasma Biomarkers.

JAMA Netw Open
Kang SH, Lee EH, Kim YJ, Jang H, Shin D, Zetterberg H, Blennow K, Gonzalez-Ortiz F, Ashton NJ, Yun J, Kim HJ, Na DL, Kim JP, Seo SW.   +13 more
europepmc   +1 more source

Genetic dissection of Alzheimer disease, a heterogeneous disorder.

, 1995
Gerard D. Schellenberg
openalex   +1 more source

Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy

Advanced Science, EarlyView.
This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou, Jia‐Xin Kou, Kai Zheng, Zi‐Xuan Guo, Hong‐Wei Fan, Wen‐Lian Li, Lu‐Lu Chu, Jing‐Wen Yin, Li‐Jie Liu, Zhi‐Gao Xiang, Feng Hu, Kai Shu, Ling‐Qiang Zhu, Dan Liu   +13 more
wiley   +1 more source

Burden of disease of Alzheimer disease in Italy: a real-world data analysis. [PDF]

BMC Health Serv Res
Mennini FS, Sciattella P, Scortichini M, Migliorini R, Trabucco Aurilio M, Marcellusi A, Bianchetti A.   +6 more
europepmc   +1 more source

The Alzheimer\u27s Disease Sequencing Project: Study design and sample selection [PDF]

, 2017
et al,, Koboldt, D. C, Larson, D. E
core   +1 more source