Results 31 to 40 of about 9,708,599 (370)

Human microglial cells synthesize albumin in brain [PDF]

, 2008
Albumin has been implicated in Alzheimer's disease since it can bind to and transport amyloid beta, the causative agent; albumin is also a potent inhibitor of amyloid beta polymerization.
Bonghee Lee, Deokhoon Kim, Jin Young Kim, Jong Shin Yoo, Kun Cho, Kyunghee Byun, Richard J. Simpson, Seung U. Kim, Sun Ha Paek, Sung-Min Ahn   +9 more
core   +5 more sources

Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future

Signal Transduction and Targeted Therapy, 2023
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer’s disease (AD), and its accumulation has been considered as the molecular driver of Alzheimer’s pathogenesis and progression.
Yun Zhang, Huaqiu Chen, Ran Li, Keenan Sterling, Weihong Song   +4 more
semanticscholar   +1 more source

Donanemab in Early Alzheimer's Disease.

New England Journal of Medicine, 2021
BACKGROUND A hallmark of Alzheimer's disease is the accumulation of amyloid-β (Aβ) peptide. Donanemab, an antibody that targets a modified form of deposited Aβ, is being investigated for the treatment of early Alzheimer's disease.
M. Mintun, A. Lo, C. Duggan Evans, A. Wessels, P. Ardayfio, S. Andersen, S. Shcherbinin, J. Sparks, J. Sims, M. Brys, L. Apostolova, S. Salloway, D. Skovronsky   +12 more
semanticscholar   +1 more source

Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer\u27s disease [PDF]

, 2019
Interest in understanding the roles of white matter (WM) inflammation and damage in the pathophysiology of Alzheimer disease (AD) has been growing significantly in recent years.
Ances, Beau M, Benzinger, Tammie L.S., Blazey, Tyler, Cairns, Nigel J, Chen, Charlie, Cruchaga, Carlos, Fagan, Anne M, Gordon, Brian A, Liu, Jingxia, Morris, John C, Shimony, Joshua S, Su, Yi, Sutphen, Courtney L, Wang, Qing, Wang, Yong   +14 more
core   +2 more sources

Alzheimer and vascular brain disease: Senile dementia. [PDF]

, 2015
Alois Alzheimer is best known for his description of a novel disease, subsequently named after him. However, his wide range of interests also included vascular brain diseases.
Engelhardt, Eliasz, Grinberg, Lea T
core   +2 more sources

2024 Alzheimer's disease facts and figures

Alzheimer's & Dementia
This article describes the public health impact of Alzheimer's disease (AD), including prevalence and incidence, mortality and morbidity, use and costs of care and the ramifications of AD for family caregivers, the dementia workforce and society.

semanticscholar   +1 more source

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Nature Communications, 2021
Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre ...
Julie Gonneaud, Alex T. Baria, Alexa Pichet Binette, Brian A. Gordon, Jasmeer P. Chhatwal, Carlos Cruchaga, Mathias Jucker, Johannes Levin, Stephen Salloway, Martin Farlow, Serge Gauthier, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, John C. S. Breitner, Judes Poirier, Etienne Vachon-Presseau, Sylvia Villeneuve, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN) Study Group, Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group   +20 more
doaj   +1 more source

PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. [PDF]

, 2012
Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines.
Cole, Greg M, Frautschy, Sally A, Ma, Qiu-Lan, Yang, Fusheng   +3 more
core   +1 more source

Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup

Alzheimer's & Dementia
The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzheimer's disease (AD).
Clifford R. Jack, J. S. Andrews, Thomas G. Beach, Teresa Buracchio, B. Dunn, Ana Graf, Oskar Hansson, Carole Ho, William Jagust, E. McDade, J. Molinuevo, O. Okonkwo, Luca Pani, M. Rafii, P. Scheltens, Eric R. Siemers, H. Snyder, R. Sperling, C. Teunissen, Maria C. Carrillo   +19 more
semanticscholar   +1 more source

A Clinicopathological Report of a 93-Year-Old Former Street Boxer With Coexistence of Chronic Traumatic Encephalopathy, Alzheimer's Disease, Dementia With Lewy Bodies, and Hippocampal Sclerosis With TDP-43 Pathology

Frontiers in Neurology, 2020
Chronic traumatic encephalopathy (CTE) was recently recognized as a new tauopathy in which multifocal perivascular phosphorylated tau aggregates accumulate in neurons, astrocytes, and neurites at the depths of the cortical sulci.
Chunhui Yang, Sukriti Nag, Sukriti Nag, Guoqiang Xing, Neelum T. Aggarwal, Neelum T. Aggarwal, Julie A. Schneider, Julie A. Schneider, Julie A. Schneider   +8 more
doaj   +1 more source