Results 41 to 50 of about 9,181,201 (335)
Discovering a reaction-diffusion model for Alzheimer's disease by combining PINNs with symbolic regression [PDF]
arXiv, 2023 Misfolded tau proteins play a critical role in the progression and pathology of Alzheimer's disease. Recent studies suggest that the spatio-temporal pattern of misfolded tau follows a reaction-diffusion type equation. However, the precise mathematical model and parameters that characterize the progression of misfolded protein across the brain remain ...
arxiv
Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup
Alzheimer's & DementiaThe National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzheimer's disease (AD).
Clifford R Jack +19 more
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Methyl-CpG Binding Protein 2 in Alzheimer Dementia [PDF]
International Neurourology Journal, 2019 Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp.
Baeksun Kim +3 more
doaj +1 more source
Predicting Alzheimer's Disease Using 3DMgNet [PDF]
arXiv, 2022 Alzheimer's disease (AD) is an irreversible neurode generative disease of the brain.The disease may causes memory loss, difficulty communicating and disorientation. For the diagnosis of Alzheimer's disease, a series of scales are often needed to evaluate the diagnosis clinically, which not only increases the workload of doctors, but also makes the ...
arxiv
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Alzheimer's Disease Detection from Spontaneous Speech and Text: A review [PDF]
arXiv, 2023 In the past decade, there has been a surge in research examining the use of voice and speech analysis as a means of detecting neurodegenerative diseases such as Alzheimer's. Many studies have shown that certain acoustic features can be used to differentiate between normal aging and Alzheimer's disease, and speech analysis has been found to be a cost ...
arxiv
Current and Future Treatments in Alzheimer Disease: An Update
Journal of Central Nervous System Disease, 2020 Disease-modifying treatment strategies for Alzheimer disease (AD) are still under extensive research. Nowadays, only symptomatic treatments exist for this disease, all trying to counterbalance the neurotransmitter disturbance: 3 cholinesterase inhibitors
K. Yiannopoulou, S. Papageorgiou
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
Acta Neuropathologica Communications, 2017 Alzheimer disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. The majority of AD cases are sporadic, while up to 5% are families with an early onset AD (EOAD).
Håkan Thonberg +11 more
doaj +1 more source