Results 41 to 50 of about 18,186 (211)

Amantadine Neurotoxicity in a Pediatric Patient with Renal Insufficiency

, 1991
Amantadine hydrochloride, a dopamine agonist with antiviral and antiparkinsonism properties, is used for the prevention and treatment of influenza A respiratory infections in high-risk populations. The occurrence of amantadine-induced hallucinations and
Dawn K. Strong, Gerald S. Arbus, Daniel S. Sitar, David D. Eisenstat, Scott M. Bryson   +4 more
core   +1 more source

The Effect of Systemic Amantadine Sulfate on Malondialdehyde and Total Thiol Levels in Rat Corneas

Journal of Ophthalmic & Vision Research, 2014
Purpose: To evaluate the malondialdehyde (MDA) and total thiol (sulfhydryl, SH) levels in rat corneas after intraperitoneal injection of amantadine sulfate.
Züleyha Yalniz-Akkaya, Vildan Fidanci, Aytul Kilinc, Ayse Burcu, Guner O Uney, Firdevs Ornek   +5 more
doaj   +1 more source

Amantadine therapy for Parkinson’s Disease: In Vivo Confocal Microscopy corneal findings, case report and revision of literature

BMC Ophthalmology, 2022
Background To report a case of a patient showing bilateral corneal opacities after amantadine chronic treatment for Parkinson’s Disease (PD) and corneal edema associated with intra-epithelial and -endothelial depositions. After amantadine discontinuation
Michela Cennamo, Francesco Dragotto, Eleonora Favuzza, Alberto Morelli, Rita Mencucci   +4 more
doaj   +1 more source

Cognitive, Motor and Oculomotor Contributions to the Trail Making Test in Progressive Supranuclear Palsy

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by motor, oculomotor and cognitive impairments. Yet disentangling cognitive deficits from motor and oculomotor dysfunction remains a diagnostic and methodological challenge.
Indira Garcia‐Cordero, Mohsen Hadian, Juan Camilo Vargas‐Gonzalez, Marta Monteiro, David Gold, Abeer Khoja, Alonso Morales‐Rivero, Blas Couto, David Tang‐Wai, Susan Fox, Gabor G. Kovacs, Anthony E. Lang, Maria Carmela Tartaglia   +12 more
wiley   +1 more source

Isoforms of PfCRT^K1 from amantadine-hypersensitive parasites transport amantadine.

, 2016
(A) Amantadine inhibits the transport of [3H]CQ via 76I-PfCRTK1 and 76I,369F-PfCRTK1 in a concentration-dependent manner (IC50s of 186 ± 16 and 174 ± 26 μM, respectively).
Michael W. Webster (622061), Rowena E. Martin (1811887), Megan N. Nash (2886380), Adele M. Lehane (1811896), Sashika N. Richards (2886377), Eileen S. Baker (2886374), Sarah H. Shafik (2886371)   +6 more
core   +1 more source

The role of amantadine as a premedication for induction of ketamine-balanced anesthesia in chick model [PDF]

Iraqi Journal of Veterinary Sciences
The objective of this research was to investigate the pharmacological effects of amantadine in 7-14 day-old chicks and to determine its safety, as well as its role in inducing ketamine-balanced anesthesia, and to compare it with the traditional mixture ...
Faisal Idris, Yaareb Mousa
doaj   +1 more source

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

Movement Disorders, EarlyView.
Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota, Jacy B. Parmera, Matheus Deltreggia, Pedro N. Martins, Anna Letícia M. Alves, Ananda C.M. de Falcone, Ana Rosa Santana, Maria Alice P. Falcão, Mayara A. Dias, Larissa I. Moreira, Paulo C. de Fonseca Filho, Eberval G. Figueiredo, Egberto R. Barbosa, Rubens G. Cury, Daniel C. de Andrade   +14 more
wiley   +1 more source

Amantadine as a Potential Treatment for Marchiafava–Bignami Disease: Case Reports and a Possible Mechanism

Case Reports in Neurological Medicine, 2022
Introduction. Several reports have described the use of amantadine for managing symptoms in Marchiafava–Bignami disease (MBD); however, amantadine’s role for the treatment of MBD symptoms is unclear. Here, we describe 2 patients with MBD who were treated
Leenil Noel, Martin Myers, Tigran Kesayan   +2 more
doaj   +1 more source

Ursodeoxycholic Acid and Parkinson's Disease Risk: An Emulated Target Trial in UK Electronic Health Records

Movement Disorders, EarlyView.
Abstract Background Ursodeoxycholic acid (UDCA) has shown mitochondrial and neuroprotective effects and has been proposed as a treatment for Parkinson's disease (PD). However, population‐level evidence on its effect on PD risk is lacking. Objectives To compare the risk of incident PD among UDCA initiators versus matched non‐initiators within a ...
Chengsheng Ju, Anette Schrag, Camille Carroll, Xi Xiong, James Carpenter, Oliver Bandmann, Thomas Foltynie, Li Wei   +7 more
wiley   +1 more source

Untargeted metabolomics reveals the mechanism of amantadine toxicity on Laminaria japonica

Frontiers in Physiology
The antiviral agent amantadine is frequently detected in seawater and marine organisms. Because of increasing concentrations, amantadine has become a contaminant of emerging concern.
Xiaohan Wang, Yao Lu, Jinxia He, Xiaojie Li, Yingjiang Xu, Lihua Ren, Huanjun Li   +6 more
doaj   +1 more source