Results 71 to 80 of about 358 (125)

Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion

Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion
Epidermal growth factor receptor (EGFR) signaling is one of the crucial factors in breast cancer malignancy. Breast cancer cells often overexpress Arf6 and its effector, AMAP1/ASAP1/DDEF1; in these cells, EGFR signaling may activate the Arf6 pathway to induce invasion and metastasis.
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ニュウガン ニ オケル AMAP1 タンパクシツ ノ ハツゲン コウシン オヨビ ソレ オ ヒョウテキ ト シタ シンジュン カッセイ ソガイ

, 2006
京都大学0048新制・課程博士博士(生命科学)甲第12479号生博第71号新制||生||11(附属図書館)24315UT51-2006-J470京都大学大学院生命科学研究科高次生命科学専攻(主査)教授 佐邊 嘉孝, 教授 下遠野 邦忠, 教授 根岸 学学位規則第4条第1項該当Doctor of Life ScienceKyoto ...
小野寺, 康仁
core  

DNA methylation analysis of the epigenome in oral squamous cell carcinoma. [PDF]

Hum Genomics
Ma J, Huang Y, Bai Y, Zhou N, Wang H, Zhang Y, Hu M, Yan J.   +7 more
europepmc   +1 more source

Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory. [PDF]

Cancer Cell Int, 2020
Luo W, Yang G, Luo W, Cao Z, Liu Y, Qiu J, Chen G, You L, Zhao F, Zheng L, Zhang T.   +10 more
europepmc   +1 more source

Clinicopathological Implications of ASAP1 Expression in Hepatocellular Carcinoma. [PDF]

Pathol Oncol Res, 2022
Bang S, Jee S, Son H, Cha H, Sim J, Kim Y, Park H, Myung J, Kim H, Paik S.   +9 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2-COL3A1 axis. [PDF]

Mol Oncol
Horak I, Zambo IS, Přikryl M, Múdry P, Zapletalová D, Navrátilová J, Navrátil J, Šmarda J, Drobot L, Beneš P, Knopfová L.   +10 more
europepmc   +1 more source

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer
Although KRAS and TP53 mutations are major drivers of pancreatic ductal adenocarcinoma (PDAC), the incurable nature of this cancer still remains largely elusive. ARF6 and its effector AMAP1 are often overexpressed in different cancers and regulate the intracellular dynamics of integrins and E-cadherin, thus promoting tumor invasion and metastasis when ...
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ARF6 promotes the nuclear translocation of β-catenin to facilitate AFP deficiency-mediated metastasis in CTNNB1^S33Y-mutant hepatocellular carcinoma. [PDF]

Cell Biol Toxicol
Zhang R, Dong L, Yang J, Guo Q, Pan D, Xun C, Wei L.   +6 more
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A lysine-rich cluster in the N-BAR domain of ARF GTPase-activating protein ASAP1 is necessary for binding and bundling actin filaments. [PDF]

J Biol Chem, 2022
Gasilina A, Yoon HY, Jian X, Luo R, Randazzo PA.   +4 more
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High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients

High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients
Background: Despite recent advances in cancer therapeutics in general, the survival of patients with head and neck squamous cell carcinomas (HNSCCs) has not improved substantially over the past few decades. HNSCC cells often exhibit invasive and metastatic phenotypes, and expression of epidermal growth factor receptor (EGFR) and cortactin has been ...
openaire   +1 more source