Results 31 to 40 of about 12,712 (251)
Viruses, 2022 Despite many efforts and diverse approaches, developing an effective herpesvirus vaccine remains a great challenge. Traditional inactivated and live-attenuated vaccines always raise efficacy or safety concerns. This study used Pseudorabies virus (PRV), a
Tong-Yun Wang +11 more
doaj +1 more source
Amber suppression in Escherichia coli by unusual mitochondria-like transfer RNAs [PDF]
Proceedings of the National Academy of Sciences, 1998 The “cloverleaf” base-pairing pattern was established as the structural paradigm of active tRNA species some 30 years ago. Nevertheless, this pattern does not accommodate the folding of certain mitochondrial tRNAs. For these recalcitrant tRNAs, we have proposed structures having from 5 to 10 base pairs in the anticodon stem rather ...
V, Bourdeau +5 more
openaire +2 more sources
IEEE Photonics Journal, 2014 We report on a blue-amber (“firelight”) cluster of light-emitting diodes (LEDs) with extra-low correlated color temperature (~1860 K) optimized for outdoor lighting under mesopic conditions.
A. Zukauskas +7 more
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Monitoring protein misfolding by site-specific labeling of proteins in vivo. [PDF]
PLoS ONE, 2014 Incorporating fluorescent amino acids by suppression of the TAG amber codon is a useful tool for site-specific labeling of proteins and visualizing their localization in living cells.
Tzung-yang Hsieh +5 more
doaj +1 more source
Rice Nudix Hydrolase OsNUDX2 Sanitizes Oxidized Nucleotides
Antioxidants, 2022 Nudix hydrolase (NUDX) hydrolyzes 8-oxo-(d)GTP to reduce the levels of oxidized nucleotides in the cells. 8-oxo-(d)GTP produced by reactive oxygen species (ROS) is incorporated into DNA/RNA and mispaired with adenine, causing replicational and ...
Yuki Kondo +2 more
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Polyamines Stimulate Suppression of Amber Termination Codons in vitro by Normal tRNAs [PDF]
European Journal of Biochemistry, 1980 Polyamines, such as spermine and spermidine, are able to stimulate reading of amber termination codons on viral messenger RNAs in vitro. This phenomenon is not due to an overall increase of error frequency during translation, but to a specific effect on a normal tRNA that is present in various eukaryotic cell preparations. The enhancement of reading of
M D, Morch, C, Benicourt
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Frontiers in Chemistry, 2014 Unnatural amino acid (UAA) incorporation by amber codon suppression offers scientists a powerful tool to modify the properties of proteins at will. UAA incorporation has been used for a plethora of fundamental research applications and, more recently ...
Huib eOvaa, kim ewals
doaj +1 more source
Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2010 New tools are needed to study the intracellular pathogen Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), to facilitate new drug discovery and vaccine development.
Feng Wang +4 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
BMC Genetics, 2009 Background Presenilin proteins are part of a complex of proteins that can cleave many type I transmembrane proteins, including Notch Receptors and the Amyloid Precursor Protein, in the middle of the transmembrane domain.
Aubert Sylvie +3 more
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