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ANALYSIS OF QUALITY INDICATORS AND PARAMETRS OF SYRUP AMBROXOL PRODUCTION USING STATISTICAL METHODS
Разработка и регистрация лекарственных средств, 2019 The quality review procedure, which is an essential improvement of the quality system by manufacturers, was used for monitoring the stability of the production process and quality of Ambroxol syrup.
S. N. Egorova +3 more
doaj
PharmaceuticsBackground: This study explores the development and characterization of spray-dried composite microparticles consisting of levofloxacin (LVX, a broad-spectrum antibiotic), and ambroxol (AMB, a mucolytic agent that has antibacterial and antibiofilm ...
Ruwani K. Suraweera +5 more
doaj +1 more source
Ambroxol, the cough expectorant with neuroprotective effects
Neural Regeneration ResearchKristin Patzwaldt +1 more
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Antioxidant properties of ambroxol
Free Radical Biology and Medicine, 1994We tested whether Ambroxol, a drug which stimulates the release of surfactant by pneumocytes type II, may also possess antioxidant properties. To assess the reactivity of Ambroxol with reactive oxygen species, we analysed its ability to decompose hydrogen peroxide (H2O2) and to inhibit the superoxide (O2.-)-dependent autooxidation of pyrogallol ...
Dariusz Nowak +2 more
exaly +3 more sources
Effect of Ambroxol of neutrophil chemotaxisin vitro
Agents and Actions, 1988Ambroxol hydrochloride has been shown to protect the lung from damage by polymorphonuclear leucocyte (PMN). In view of this observation we have studied the effect of Ambroxol on PMN chemotaxis using a variety of chemoattractants. The PMN response was inhibited 50-80% by preincubating the cells with concentrations of 10(-4) M Ambroxol.
Stockley R A, Burnett D
exaly +3 more sources
Ambroxol Is a Scavenger of Hypochlorous Acid and Monochloramine
Pharmacology, 2008Experimental studies have suggested that ambroxol, a drug clinically used to enhance pulmonary surfactant production, may also exert some anti-inflammatory effects, though specific mechanisms are not yet fully understood. Thus, potential scavenging properties of ambroxol towards the most toxic neutrophil-arising prooxidants hypochlorous acid and ...
LAPENNA, Domenico +3 more
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A Controlled Trial of Ambroxol in Chronic Bronchitis
Chest, 1987Ambroxol is a mucolytic agent which is widely used in chronic bronchitis in Europe. We conducted a double-blind randomized controlled trial of ambroxol vs matched placebo in 90 patients with chronic bronchitis and difficulty clearing secretions. It was concluded that there was no advantage to taking ambroxol.
G H, Guyatt +3 more
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Ambroxol-Induced Focal Epileptic Seizure
Clinical Neuropharmacology, 2014It is well known that in epileptic patients some compounds and different drugs used for the treatment of comorbidities can facilitate or provoke seizures, this evidence regarding a wide spectrum of pharmacological categories. The potential facilitating factors usually include direct toxic effects or pharmacological interactions of either active ...
LAPENTA, Leonardo +6 more
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Sonolytic debromination of ambroxol process wastewater
Water Research, 2003In this study ultrasound was examined in terms of its effectiveness in treating wastewater containing ambroxol and process water from ambroxol synthesis. The organic bromine contents of the water samples investigated were in the 20-1200 mg l(-1) range. Ultrasound is capable to debrominate the ambroxol molecule rendering it biologically degradable.
Holger, Brüggemann +3 more
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