Results 71 to 80 of about 3,769 (208)

Ambroxol Inhibits Na+ Absorption by Canine Airway Epithelial Cells in Culture

, 1991
To study the effect of ambroxol on ion transport functions of airway mucosa, we measured bioelectric properties of canine cultured tracheal epithelium under short-circuit conditions in-vitro.
Jun Tamaoki, Atsushi Chiyotani, Satomi Takeuchi, Fumiko Yamauchi, Takao Takizawa   +4 more
core   +1 more source

From Regeneration Failure to Functional Restoration: Unlocking the Neuronal‐Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Optic neuropathy and glaucoma cause permanent visual deficits via retinal ganglion cell (RGC) loss and axon degeneration, affecting millions worldwide. Current treatments slow disease progression but cannot restore lost vision due to regeneration failure in adult RGCs.
Emma Beard, Safa El‐Bushra, Zahra Kader, Yujiao Jennifer Sun, Ngan Pan Bennett Au   +4 more
wiley   +1 more source

Ambroxol effects in glucocerebrosidase and -synuclein transgenic mice [PDF]

, 2016
Objective. Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase.
Schapira, AHV, Daly, L, Migdalska-Richards, A, Bezard, E   +3 more
core  

Rapid and long‐lasting efficacy of high‐dose ambroxol therapy for neuronopathic Gaucher disease: A case report and literature review

Molecular Genetics & Genomic Medicine
Gaucher disease (GD) is a lysosomal storage disorder caused by a deficiency in the GBA1‐encoded enzyme, β‐glucocerebrosidase. Enzyme replacement therapy is ineffective for neuronopathic Gaucher disease (nGD).
Kanako Higashi, Yuri Sonoda, Noriyuki Kaku, Fumihiko Fujii, Fumiya Yamashita, Sooyoung Lee, Vlad Tocan, Go Ebihara, Wakato Matsuoka, Kenichi Tetsuhara, Motoshi Sonoda, Pin Fee Chong, Yuichi Mushimoto, Kanako Kojima‐Ishii, Masataka Ishimura, Yuhki Koga, Atsuhisa Fukuta, Nana Akagi Tsuchihashi, Yoshikazu Kikuchi, Takahito Karashima, Takaaki Sawada, Taeko Hotta, Makoto Yoshimitsu, Hideyuki Terazono, Tatsuro Tajiri, Takashi Nakagawa, Yasunari Sakai, Kimitoshi Nakamura, Shouichi Ohga   +28 more
doaj   +1 more source

Electrochemical Behavior of Ambroxol and Its Determination in Pharmaceutical Dosage Forms on MWCNT/Nafion Modified Glassy Carbon Electrodes

International Journal of Electrochemical Science, 2012
The electrochemical behavior of ambroxol was investigated on MWCNT/Nafion modified glassy carbon electrodes. In cyclic voltammetry, the compound showed an irreversible oxidation peak.
Yuanzhe Piao
doaj   +1 more source

Differential modulation of IgE-dependent activation of human basophils by ambroxol and related secretolytic analogues.

, 2009
Ambroxol is a widely used secretolytic agent originally developed from vasicine, a natural alkaloid found in Adhatoda vasica, extracts of which have been used to treat bronchitis, asthma, and rheumatism.
Gibbs, Bernhard F
core  

Does Ambroxol alleviate kidney ischemia-reperfusion injury in rats?

, 2022
Objective(s): Ischemia-reperfusion injury is a life-threatening clinical problem that can occur after transplantation or a number of clinical procedures.
ÇETİNEL, ŞULE
core   +1 more source

Characterization of differential patient profiles and therapeutic responses of pharmacy customers for four ambroxol formulations

BMC Pharmacology and Toxicology, 2018
Background Ambroxol relieves cough symptoms based on its secretagogue, anti-inflammatory, anti-oxidant, anti-bacterial, anti-viral, immunomodulatory and local anesthetic effects. The present study was designed to explore differential patient profiles and
Peter Kardos, Kai-Michael Beeh, Ulrike Sent, Tobias Mueck, Heidemarie Gräter, Martin C. Michel   +5 more
doaj   +1 more source

Scaffolds for sustained release of ambroxol hydrochloride, a pharmacological Chaperone that Increases the Activity of Misfolded ß-Glucocerebrosidase [PDF]

, 2019
Ambroxol is a pharmacological chaperone (PC) for Gaucher disease that increases lysosomal activity of misfolded ß-glucocerebrosidase (GCase) while displaying a safe toxicological profile.
Saperas Plana, Núria, Hamidreza Enshaei, Estrany Coda, Francesc, Brenda G. Molina, Alemán Llansó, Carlos, Jordi Puiggalí, Enshaei, Hamidreza, Luis J. del Valle, Núria Saperas, Valle Mendoza, Luis Javier del, Molina, Brenda G., Carlos Alemán, Francesc Estrany, Carme Arnan, Arnan, Carme, Puiggalí Bellalta, Jordi   +15 more
core   +1 more source

Meta analysis of curative effect and safety of different doses of ambroxol for lung cancer patients in perioperative period

Huli yanjiu, 2015
To systematically assess the curative effect and safety of different doses of ambroxol for lung cancer patients in perioperative period.Methods:The randomised or quasi-randomized controlled trials RCTs) on the application of different doses of ambroxol ...
冯莉, 王爱平
doaj