Results 51 to 60 of about 305 (130)

Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids

Movement Disorders, Volume 41, Issue 3, Page 581-595, March 2026.
Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, Volume 41, Issue 3, Page 596-602, March 2026.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

Non‐Pulmonary Mechanisms of Action of Ambroxol in In Vivo Experimental Models: a Systematic Review

Fundamental &Clinical Pharmacology, Volume 40, Issue 2, March 2026.
ABSTRACT Background Repositioning offers a cost‐effective approach to discovering new therapeutic applications for existing medications. Ambroxol, primarily used as a mucolytic for respiratory diseases, has demonstrated anti‐inflammatory, analgesic, and antioxidant properties, suggesting potential benefits in non‐pulmonary conditions.
Michelline Joana Tenório Albuquerque Madruga Mesquita, Anne Caroline Silva Nogueira da Cruz, Rafael de Abreu Lima, Joana Tenório‐Meireles, Arney José Nogueira Farias, Isabela Nogueira Santos, Gustavo Frota, Taciana Gabrielle Pinheiro de Moura Carvalho, Rafael Antônio Freire Carvalho, Jorge Antônio Meireles‐Teixeira, Tereza Prazeres, Rafael Cardoso Carvalho, Maria do Socorro de Sousa Cartágenes, João Batista Santos Garcia   +13 more
wiley   +1 more source

Ambroxol as a novel disease-modifying treatment for Parkinson’s disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial

BMC Neurology, 2019
Background Currently there are no disease-modifying treatments for Parkinson’s disease dementia (PDD), a condition linked to aggregation of the protein α-synuclein in subcortical and cortical brain areas.
C. R. A. Silveira, J. MacKinley, K. Coleman, Z. Li, E. Finger, R. Bartha, S. A. Morrow, J. Wells, M. Borrie, R. G. Tirona, C. A. Rupar, G. Zou, R. A. Hegele, D. Mahuran, P. MacDonald, M. E. Jenkins, M. Jog, S. H. Pasternak   +17 more
doaj   +1 more source

From Regeneration Failure to Functional Restoration: Unlocking the Neuronal‐Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Optic neuropathy and glaucoma cause permanent visual deficits via retinal ganglion cell (RGC) loss and axon degeneration, affecting millions worldwide. Current treatments slow disease progression but cannot restore lost vision due to regeneration failure in adult RGCs.
Emma Beard, Safa El‐Bushra, Zahra Kader, Yujiao Jennifer Sun, Ngan Pan Bennett Au   +4 more
wiley   +1 more source

Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 1, Page 25-55, February 2026.
ABSTRACT Chronic rhinosinusitis (CRS), a complex inflammatory disease with heterogeneous pathogenesis, demands evolving evidence‐based strategies. Since the 2018 Chinese guidelines and EPOS2020, international advances in CRS immunopathology and biologics have revolutionized therapeutic approaches, particularly through phenotype–endotype classification ...
Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association   +4 more
wiley   +1 more source

From Molecule to Meaning: Neuronopathic Biomarkers and Clinical Relevance in GM1

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT GM1 gangliosidosis is a rare, progressively neurodegenerative lysosomal storage disorder characterized by profound central nervous system involvement and substantial clinical heterogeneity. The development of reliable biomarkers is essential for tracking disease progression, stratifying patients, and advancing clinical trial readiness. Primary
Krista Casazza, Roberto Giugliani, Debra S. Regier, Jeanine Jarnes   +3 more
wiley   +1 more source

Effect and Safety of Bronchoscopy Based on Imaging Evaluation in Patients With Acute Exacerbation of Bronchiectasis

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Objective To evaluate the efficacy and safety of imaging‐assisted bronchoscopic interventions in acute bronchiectasis exacerbations and analyze their effects on pulmonary function, inflammation, and quality of life for evidence‐based clinical support.
Biliang Li, Zeng Juan, Mingfeng Wang, Wei Kang, Bo Li, Lipi Buch   +5 more
wiley   +1 more source

Pustular Rosacea in an 8‐Year‐Old Patient: A Rare Presentation of Pediatric Rosacea

Case Reports in Dermatological Medicine, Volume 2026, Issue 1, 2026.
Pustular rosacea is a rare chronic inflammatory disease whose prevalence increases with age. We report a case of an 8‐year‐old patient who presented with a 3‐year history of recurrent papulopustular facial eruptions associated with severe burning sensation, primarily affecting the cheeks, nose, and chin, exacerbated by hot weather and swimming.
Razan Sharaf, Tasneem Assaf, Usra I. Ghanem, Hadeel Abed Alhameed, Rabee Adwan, Sergio A. Cuevas Covarrubias   +5 more
wiley   +1 more source

Anthelmintic Effect of Chitosan‐Encapsulated Bromelain on Gastrointestinal Nematodes in Naturally Infected Goats in Kenya

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
The emergence of anthelmintic resistance calls for the development of alternatives, including medicinal plant extracts. The present study was aimed at assessing the efficacy of chitosan‐encapsulated bromelain (EB) as an oral solution drug against GIN in goats.
Ahmota Romain Daïba, Issa Youssouf Adoum, Maina Ngotho, John Maina Kagira, Naomi Maina, Bernard Marchand   +5 more
wiley   +1 more source