Results 41 to 50 of about 305 (130)

Genetic Variants and Clinical Characteristics of Young‐Onset Parkinson's Disease in the Hakka Population of Western Fujian

Brain and Behavior, Volume 16, Issue 6, June 2026.
In 33 Hakka young‐onset Parkinson's disease (YOPD) patients from western Fujian, whole exome sequencing (WES) plus spinocerebellar ataxia (SCA) panel testing and multiplex ligation‐dependent probe amplification (MLPA) defined the genetic spectrum. Pathological ATXN2 repeat expansion was detected in two cases.
Li‐Ying Pan, Fang Guo, Chong Zheng, Xiao‐Hong Hu, Yan‐Gui Chen, Rong‐Rong Lin   +5 more
wiley   +1 more source

Ambroxol attenuates detrimental effect of LPS-induced glia-mediated neuroinflammation, oxidative stress, and cognitive dysfunction in mice brain

Frontiers in Immunology
Neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), are multifactorial. Among various factors, lipopolysaccharides (LPSs) from Gram-negative bacteria, such as E.
Safi Ullah, Tae Ju Park, Jun Sung Park, Abubakar Atiq, Jawad Ali, Min Hwa Kang, Waqar Ali, Kyonghwan Choe, Kyonghwan Choe, Myeong Ok Kim, Myeong Ok Kim   +10 more
doaj   +1 more source

Plasma Glucosylsphingosine in GBA1 E365K, N409S, and L483P Heterozygous Mutation Carriers

Movement Disorders, Volume 41, Issue 5, Page 1304-1309, May 2026.
Abstract Background GBA1 encodes the lysosomal enzyme glucocerebrosidase, with key substrates that include glucosylceramide and glucosylsphingosine. The E365K variant is the most common variant in GBA1 that is associated with Parkinson's disease (PD) but is not associated with Gaucher disease.
Julian Agin‐Liebes, Alexander Haimovich, Rachel Griep, Nathan Galen Hatcher, Lihang Yao, Cheryl Waters, Shalini Padmanabhan, Roy N. Alcalay   +7 more
wiley   +1 more source

Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis

Frontiers in Pharmacology, 2019
Amyotrophic lateral sclerosis (ALS) is a multifactorial and fatal neurodegenerative disease. Growing evidence connects sphingolipid metabolism to the pathophysiology of ALS.
Alexandra Bouscary, Alexandra Bouscary, Cyril Quessada, Cyril Quessada, Althéa Mosbach, Althéa Mosbach, Noëlle Callizot, Michael Spedding, Jean-Philippe Loeffler, Jean-Philippe Loeffler, Alexandre Henriques, Alexandre Henriques, Alexandre Henriques   +12 more
doaj   +1 more source

Use of Ambroxol as Therapy for Gaucher Disease

JAMA Network Open, 2023
ImportanceAmbroxol was identified as an enhancer of stability and residual activity of several misfolded glucocerebrosidase variants in 2009.ObjectivesTo assess hematologic and visceral outcomes, biomarker changes, and safety of ambroxol therapy for patients with Gaucher disease (GD) without disease-specific treatment.Design, Setting, and ...
Zhan, Xia, Zhang, Huiwen, Maegawa, Gustavo H. B., Wang, Yu, Gao, Xiaolan, Wang, Dengbin, Li, Jinning   +6 more
openaire   +2 more sources

A Rare Case Report of Neuroimaging, Electrophysiological, and Dynamic Laryngoscopy Studies in a Stroke Patient of Foix‐Chavany‐Marie Syndrome

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Foix‐Chavany‐Marie Syndrome (FCMS), also known as opercular syndrome, is a rare neurological disorder caused by an ischemic stroke that results in autonomic‐voluntary dissociation. In this case report, we describe a patient who presented with an acute right frontal and parietal cortical lesion, in addition to a remote infarction in the left ...
Lu Xia, Liyan Cai, Xin Chen, Wei Huang, Cen Chen, Shinian Yang, Qing Chen, Yuanyuan Zhu   +7 more
wiley   +1 more source

COVID‐19 Prophylactic Effect of Bromhexine Hydrochloride

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
ABSTRACT Introduction Despite extensive efforts to identify effective treatments for COVID‐19, preventive strategies remain essential. Bromhexine hydrochloride (BRH), an over‐the‐counter mucolytic with potential TMPRSS2 inhibition, may reduce viral entry and thus serve as a prophylactic agent.
Vanyo Mitev, Tsanko Mondeshki, Ani Miteva, Konstantin Tachkov, Violeta Dimitrova   +4 more
wiley   +1 more source

Polypharmacology of ambroxol in the treatment of COVID-19

Bioscience Reports, 2023
AbstractThe pandemic of coronavirus disease 2019 (COVID-19) by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still underway. Due to the growing development of severe symptoms, it is necessary to promote effective therapies. Ambroxol [2-amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl) benzylamine] has long been used as one of the over ...
Ziyuan Wang, Minghui Yang, Xi Chen, Rongxin Xiao, Yu Dong, Ming Chu, Guojie Song, Yuedan Wang   +7 more
openaire   +2 more sources

Analysis of Solubility, pH, Antimicrobial Action and Cytotoxicity of Calcium Hydroxide Paste Associated With Ambroxol Hydrochloride

Australian Endodontic Journal, Volume 52, Issue 1, Page 148-155, April 2026.
ABSTRACT This study evaluated the association of ambroxol hydrochloride with calcium hydroxide paste as intracanal medication to enhance antimicrobial action on biofilm without affecting pH, solubility and cytotoxicity. Calcium hydroxide (CH) paste and formulations with different ambroxol concentrations were placed into artificial teeth conditioned in ...
Thaís Ferreira Rodrigues Mota, Ana Flávia Balestrero Cassiano, Pedro César Gomes Titato, Pedro Henrique Souza Calefi, Murilo Priori Alcalde, Gisele Faria, Marco Antonio Hungaro Duarte   +6 more
wiley   +1 more source

РАЦИОНАЛЬНОЕ ЛЕЧЕНИЕ КАШЛЯ НА ЭТАПЕ ПЕРВИЧНОГО МЕДИКО-САНИТАРНОГО ЗВЕНА И В УСЛОВИЯХ СТАЦИОНАРА. ДИСКУССИЯ

Архивъ внутренней медицины, 2013
Archiv vnutrenney meditsiny presents material on rational treatment of cough in modern conditions to physicians and communicating specialists. The article states medical practitioner’s points of view on ambroxol (Ambrobene) and clinical cases where this ...
В. И. Трофимов, Н. А. Былова, И. С. Добротина, Л. Ю. Долинина   +3 more
doaj   +1 more source