Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons [PDF]
, 2018 Glucocerebrosidase (GBA1) mutations are the major genetic risk factor for Parkinson's Disease (PD). The pathogenic mechanism is still unclear, but alterations in lysosomal-autophagy processes are implicated due to reduction of mutated glucocerebrosidase (
Gegg, ME +3 more
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Validasi Metode Analisis Klorfeniramin Maleat Dan Guaifenesin Menggunakan Kromatografi Cair Kinerja Tinggi Serta Aplikasinya Dalam Sediaan Sirup [PDF]
, 2017 The combination of CTM and GG is often used as an active substances to relieve symptoms of cough and cold. The concentration of CTM and GG in syrup are very low, so that it need validated determination method to ensure therapeutic dose. The purposes of
Afifah, I. (Ira), Budiarti, A. (Aqnes)
core +5 more sources
Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models [PDF]
, 2016 GBA gene mutations are the greatest cause of Parkinson disease (PD). GBA encodes the lysosomal enzyme glucocerebrosidase (GCase) but the mechanisms by which loss of GCase contributes to PD remain unclear.
Beavan, M +5 more
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Flow injection analysis using carbon film resistor electrodes for amperometric determination of ambroxol [PDF]
, 2008 Flow injection analysis (FIA) using a carbon film sensor for amperometric detection was explored for ambroxol analysis in pharmaceutical formulations.
Angnes, Lúcio +2 more
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An animal study on the effect of topically administered ambroxol for dry eye
Frontiers in Bioscience-Landmark, 2022 Objective: To evaluate the effect of 0.2% ambroxol eye drop on tear secretion and corneal healing on a rabbit dry eye model, and to delineate potential underlying mechanisms.
Zixuan Wang +4 more
doaj +1 more source
Frontiers in Medicine, 2023 BackgroundAmbroxol is a widely used mucoactive drug in sputum clearance of respiratory diseases taken orally and by injection. However, there is a paucity of evidence for inhaled ambroxol in sputum clearance.MethodsThis study performed a multicenter ...
Zeguang Zheng +23 more
doaj +1 more source
Spectrophotometric Determination of Ambroxol by Chromotropic acid disodium salt dihydrate [PDF]
Journal of Bioscience and Applied ResearchAn easy and prompt spectrophotometric method was proposed for the limitation of the drug Ambroxol substance containing the amine group by the organic reagent (4,5-Dihydroxynaphthalene-2,7-disulfonic acid disodium salt dihydrate).
Riyadh R. Al - Araji +1 more
doaj +1 more source
Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. [PDF]
, 2014 Gaucher disease is caused by mutations in the glucocerebrosidase gene, which encodes the lysosomal hydrolase glucosylceramidase. Patients with Gaucher disease and heterozygous glucocerebrosidase mutation carriers are at increased risk of developing ...
Abramov, AY +10 more
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Frontiers in Neurology, 2022 Gaucher Disease (GD) 2 is a rare inherited lysosomal disorder. Early-onset and rapid progression of neurovisceral symptoms lead to fatal outcome in early childhood. Treatment is symptomatic, a curative therapy is currently not available. This prospective
Charlotte Aries +8 more
doaj +1 more source
Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts [PDF]
, 2016 A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been synthesized. The key step involved a totally stereocontrolled C-Michael addition of a serine-equivalent C-nucleophile to tri-O ...
Avenoza, A. +9 more
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