Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1. [PDF]
World J GastroenterolAlruhaimi RS +6 more
europepmc +2 more sources
The Race to Salvage Glucocerebrosidase: Understanding Small-Molecule Therapies for GBA1-Associated Parkinsonism. [PDF]
Mov DisordVariants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Henderson MJ +5 more
europepmc +2 more sources
Фармацевтичний журнал, 2020 The determination of the qualitative and quantitative content of the main active substance of a microlitic medicinal product is necessary to confirm its good quality.
І. V. Nigencovska +3 more
doaj +1 more source
Ambroxol: A potential therapeutics against neurodegeneration
Health Sciences Review, 2023 Ambroxol hydrochloride is a pharmacological chaperone approved by FDA as an expectorant. Currently, it is used as an antitussive and anti-asthmatic agent.
Prajwal Dhanve +4 more
doaj +1 more source
Ambroxol therapy for Parkinson’s disease: Systematic literature review [PDF]
Romanian Journal of Neurology, 2023 Parkinson’s disease (PD) is the second most common neurodegenerative disease. The accumulation of α-synuclein protein in the basal ganglia is the underlying pathogenesis of PD. Genetic abnormalities are one of the predisposing factors for PD.
Virgi Mayang Maharani +3 more
doaj +1 more source
COVID-19 Prophylactic Effect of Bromhexine Hydrochloride. [PDF]
Immun Inflamm DisABSTRACT Introduction Despite extensive efforts to identify effective treatments for COVID‐19, preventive strategies remain essential. Bromhexine hydrochloride (BRH), an over‐the‐counter mucolytic with potential TMPRSS2 inhibition, may reduce viral entry and thus serve as a prophylactic agent.
Mitev V +4 more
europepmc +2 more sources
Rational mucolytic therapy with ambroxol: controversial and indisputable. A review
Consilium Medicum, 2023 Many years of experience in the use of ambroxol is based on its ability to regulate the basic mechanisms of physiological production and transport of bronchial mucus.
Sergey L. Babak +2 more
doaj +1 more source
PERBANDINGAN MUTU FISIK TABLET AMBROXOL MEREK DAGANG X DANTABLETMBROXOL GENERIK
Jurnal Farmasi Sains dan Praktis, 2018 Ambroxol adalah salah satu obat yang masuk kedalam golongan mukolitik. Dimana tujuan dari penelitian ini adalah mengetahui perbandingan mutu fisik tablet Ambroxol merek dagang dan tablet Ambroxol generik.
oktavia friski +2 more
doaj +1 more source
Beneficial effects of ambroxol hydrochloride on pentylenetetrazol-induced convulsion model in rats
Medicine Science, 2020 In present experimental study, we purposed to research if ambroxol would have beneficial acute effects on PTZ-induced convulsions by EEG records. 48 rats were randomly divided into two groups; group A for EEG recordings and B for behavioral evaluations ...
Eda Sunnetci +3 more
doaj +1 more source
Human peritoneal mesothelial cell death induced by high-glucose hypertonic solution involves Ca2+ and Na+ ions and oxidative stress with the participation of PKC/NOX2 and PI3K/Akt pathways [PDF]
, 2017 Indexación: Web of Science; Scopus.Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD,
Alejandro Pacheco +13 more
core +2 more sources