Results 11 to 20 of about 5,719 (245)

Prevention of the disrupted enamel phenotype in Slc4a4-null mice using explant organ culture maintained in a living host kidney capsule. [PDF]

, 2014
Slc4a4-null mice are a model of proximal renal tubular acidosis (pRTA). Slc4a4 encodes the electrogenic sodium base transporter NBCe1 that is involved in transcellular base transport and pH regulation during amelogenesis.
Kurtz, Ira, Paine, Michael L, Wen, Xin
core   +33 more sources

Epiprofin Transcriptional Activation Promotes Ameloblast Induction From Mouse Induced Pluripotent Stem Cells via the BMP-Smad Signaling Axis [PDF]

Frontiers in Bioengineering and Biotechnology, 2022
The transcriptional regulation of induced pluripotent stem cells (iPSCs) holds promise for their directed differentiation into ameloblasts, which are usually lost after tooth eruption.
Xinchao Miao, Xinchao Miao, Kunimichi Niibe, Yunyu Fu, Maolin Zhang, Maolin Zhang, Praphawi Nattasit, Yumi Ohori-Morita, Takashi Nakamura, Xinquan Jiang, Hiroshi Egusa, Hiroshi Egusa   +11 more
doaj   +2 more sources

The Unfolded Protein Response in Amelogenesis and Enamel Pathologies [PDF]

Frontiers in Physiology, 2017
During the secretory phase of their life-cycle, ameloblasts are highly specialized secretory cells whose role is to elaborate an extracellular matrix that ultimately confers both form and function to dental enamel, the most highly mineralized of all ...
Steven J. Brookes, Martin J. Barron, Michael J. Dixon, Jennifer Kirkham   +3 more
doaj   +10 more sources

Odontogenesis-associated phosphoprotein (ODAPH) Promotes Ameloblast adhesion and alkaline phosphatase (ALP) expression via LAMC2/ ITGB6/TGF-β1 signaling pathway. [PDF]

PLoS ONE
Recessive hypomineralized amelogenesis imperfecta has been linked to mutations in Odontogenesis-Associated Phosphoprotein (ODAPH). Consistent with human phenotypes, Odaph-null mice exhibit defective enamel mineralization with ameloblast detachment from ...
Mingyue Li, Jie Zhang, Shuang Xiao, Xinyang Liu, Shuai Song, Xiaoyuan Ye, Ruonan Bi, Yuguang Gao, Li Zhang   +8 more
doaj   +2 more sources

Tissue Engineering Using Differentiation of Endometrial Stem Cells into Ameloblast Cells and Implantation on Hydroxyapatite and Collagen Nanocomposite Scaffold

Biomedical and Biotechnology Research Journal
Background: Dental tissue engineering (DTE) is an inspiring biological approach to replacing lost teeth. The strength of the differentiation of basic endometrial cells to ameloblasts is yet to be fully understood. Moreover, the construction of a scaffold,
Naghmeh Bahrami, Azadeh Babaei, Sadegh Shirian, Arman Ai, Abdolreza Mohamadnia, Shadi Shafaghi, Asma Pishbin, Jafar Ai   +7 more
doaj   +2 more sources

Energy metabolic shift contributes to the phenotype modulation of maturation stage ameloblasts [PDF]

Frontiers in Physiology, 2022
Maturation stage ameloblasts (M-ABs) are responsible for terminal enamel mineralization in teeth and undergo characteristic cyclic changes in both morphology and function between ruffle-ended ameloblasts (RA) and smooth-ended ameloblasts (SA).
Haruno Arai, Haruno Arai, Akira Inaba, Akira Inaba, Shojiro Ikezaki, Mika Kumakami-Sakano, Marii Azumane, Marii Azumane, Hayato Ohshima, Kazumasa Morikawa, Hidemitsu Harada, Keishi Otsu   +11 more
doaj   +2 more sources

Crucial Roles of microRNA-16-5p and microRNA-27b-3p in Ameloblast Differentiation Through Regulation of Genes Associated With Amelogenesis Imperfecta

Frontiers in Genetics, 2022
Amelogenesis imperfecta is a congenital disorder within a heterogeneous group of conditions characterized by enamel hypoplasia. Patients suffer from early tooth loss, social embarrassment, eating difficulties, and pain due to an abnormally thin, soft ...
Akiko Suzuki, Akiko Suzuki, Hiroki Yoshioka, Hiroki Yoshioka, Teng Liu, Aania Gull, Aania Gull, Naina Singh, Thanh Le, Thanh Le, Zhongming Zhao, Zhongming Zhao, Zhongming Zhao, Junichi Iwata, Junichi Iwata, Junichi Iwata   +15 more
doaj   +2 more sources

The role of the TGF-β1 signaling pathway in the process of amelogenesis [PDF]

Frontiers in Physiology
Amelogenesis is a highly regulated process involving multiple signaling pathways, among which the transforming growth factor-β1 (TGF-β1) signaling pathway plays a pivotal role in enamel formation.
Xiaoxue Ma, Yunjing Ma, Zhiyong Lin, Mei Ji   +3 more
doaj   +2 more sources

Small molecules direct the generation of ameloblast-like cells from human embryonic stem cells [PDF]

Stem Cell Research & Therapy
Background Ameloblasts present a promising avenue for the investigation of enamel and tooth regeneration. Previous protocols for directing the differentiation of human embryonic stem cells (hESCs) into dental epithelial (DE) cells involving the need for ...
Ximei Zhu, YiMeng Zhao, Xiaofan Bai, Qiannan Dong, Chunli Tian, Ruilin Sun, Congjuan Yan, Jianping Ruan, Zhongbo Liu, Jianghong Gao   +9 more
doaj   +2 more sources

Lats1/2 Differentially Modulate the Proliferative State of Dental Epithelial Progenitors and Ameloblasts in the Murine Incisor. [PDF]

Orthod Craniofac Res
ABSTRACT Objective(s) Yes‐Associated Protein (YAP) is a critical regulator of cell proliferation and differentiation, having the capacity to convert differentiated cells into somatic stem cells in several contexts. Here we investigate the plasticity of adult mouse dental epithelial cells by testing the effects of ectopic YAP activation in dental ...
Zhang Z, Upadhyay S, Luong C, Du W, Hu JK.   +4 more
europepmc   +2 more sources