Results 251 to 260 of about 460,138 (357)

Asymmetric Synthesis of Highly Substituted Spiro[2H‐pyrrole‐2,3‐Succinimide] Derivatives by Copper‐Catalyzed Post‐Ugi Reactions

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Abstract Herein we present a novel one‐pot methodology for the synthesis of enantioenriched 2H‐pyrrolespirosuccinimides by copper‐catalyzed reactions on Ugi adducts derived from enantiopure α‐alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen
Javier Gómez‐Ayuso   +3 more
wiley   +1 more source

Structural and Mechanistic Insights into Atypical Bacterial Topoisomerase Inhibitors. [PDF]

open access: yesACS Med Chem Lett
Toth PD   +8 more
europepmc   +1 more source

Pot‐Economical Synthesis of Fluorinated Pyrrolizinone Derivatives

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Abstract A new family of fluorinated dihydropyrrolizinones has been synthesized starting from fluorinated enamino amides and aliphatic conjugated ketones. The reaction comprises a cross metathesis reaction followed by a tandem cycloaromatization/ enamine hydrolysis/ intramolecular Friedel‐Crafts alkylation sequence.
Lidia Prieto   +6 more
wiley   +1 more source

Dearomative, Intramolecular Bromoetherification of Carbohydrate‐derived Glycosyl Furans: Access to Enantiopure 6‐Bromo‐Furo[3,2‐b]furans

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Abstract Glycosyl furans represent versatile chiral platform molecules that can be readily accessed via the Garcia Gonzalez reaction. Herein, we report a dearomative, intramolecular bromoetherification of carbohydrate‐derived glycosyl furans to generate enantiopure 6‐bromo‐furo[3,2‐b]furans in up to 69% yield. The method employs N‐Br aromatic amides as
William J. Berkey   +5 more
wiley   +1 more source

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